Results 11 to 20 of about 105,578,950 (193)
Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke. [PDF]
Ann NeurolObjectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Solo Nomenjanahary M +21 more
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Thrombolytic Therapy Targeting Alpha 2-Antiplasmin [PDF]
Circulation, 2017 Article, see p 1011 Tissue plasminogen activator (tPA) has been used as a thrombolytic agent for many years based on its high fibrin specificity, which contributes to its safety in thrombolytic therapy.1,2 Despite the favorable results associated with tPA treatments, its use is limited to the first 4.5 hours after the onset of event, and the dosage ...
Tetsumei, Urano, Yuko, Suzuki
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How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation. [PDF]
Int J Lab HematolABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Mehic D +3 more
europepmc +2 more sources
Toxins, 2020 Bleeding is a common hemostatic disorder that occurs in Bothrops envenomations. We evaluated the changes in coagulation, fibrinolysis components, and platelets in Bothrops atrox envenomations with bleeding. This is an observational study with B.
Sâmella S. Oliveira +16 more
doaj +1 more source
Brain Hemorrhages, 2020 Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH and nine healthy controls (HC) in a single-center study.
Zhe Kang Law +5 more
doaj +1 more source
α2-Antiplasmin as a Potential Therapeutic Target for Systemic Sclerosis
, 2022 Systemic sclerosis is a connective tissue disease of unknown origin that is characterized by immune system abnormalities, vascular damage, and extensive fibrosis of the skin and visceral organs.
En Shu, Yosuke Kanno
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Coagulation disorders in the patients with deep vein thrombosis of lower extremity [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2003 PURPOSE Venous thromboembolism is a relevant social and health care problem for its high incidence, pulmonary embolism-related mortality and long-term sequelae which may be disabling (post-thrombotic syndrome and ulceration).
Milić Dragan J. +5 more
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The kidney is a major site of alpha(2)-antiplasmin production. [PDF]
Journal of Clinical Investigation, 1996 The serpin alpha2-antiplasmin (alpha2-AP) is the major circulating inhibitor of plasmin; it plays a determining role in the regulation of intravascular fibrinolysis, In addition to blood plasma, plasmin formation occurs in various organs where it is thought to fulfill a spectrum of functions not restricted to clot lysis.
Menoud, P. A. +4 more
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Scientific Reports, 2021 Venous thromboembolism is a significant source of morbidity and mortality worldwide. Catheter-directed thrombolytics is the primary treatment used to relieve critical obstructions, though its efficacy varies based on the thrombus composition.
Samuel A. Hendley +12 more
doaj +1 more source
Alpha II Antiplasmin Deficiency Complicating Pregnancy: A Case Report [PDF]
, 2011 Background. Alpha II antiplasmin is a protein involved in the inhibition of fibrinolysis. A deficiency in this protein leads to increased hemorrhage. It is inherited in an autosomal recessive fashion. Case.
Brenda Dawley
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