Results 1 to 10 of about 18,078,412 (185)

Alpha 2-antiplasmin deficiency in a Sudanese child: a case report [PDF]

Journal of Medical Case Reports, 2021
Background The plasma serine protease inhibitor alpha 2-antiplasmin (α2-AP, otherwise known as α2-plasmin inhibitor) is a rapid-acting plasmin inhibitor recently found in human plasma, which seems to have a significant role in the regulation of in vivo ...
Bashir Abdrhman Bashir Mohammed
doaj   +5 more sources

Serum apolipoprotein A-II and alpha-2-antiplasmin levels in midtrimester can be used as predictors of preterm delivery [PDF]

Journal of International Medical Research, 2020
Objective To identify serum protein markers in midtrimester that predict preterm delivery. Methods A retrospective case–control study randomly selected patients that experienced spontaneous preterm birth and healthy control patients that experienced a ...
Jianxia Huang, Pei He
exaly   +3 more sources

Generation and characterization of monoclonal antibodies against the N-terminus of alpha-2-antiplasmin. [PDF]

PLoS ONE, 2018
Around 70% of circulating alpha-2-antiplasmin (α2AP), the main natural plasmin inhibitor, is N-terminally cleaved between residues Pro12 and Asn13 by antiplasmin-cleaving enzyme.
Shiraazkhan Abdul, Miet Peeters, Els Brouwers, Joyce J M C Malfliet, Frank W G Leebeek, Paul J Declerck, Dingeman C Rijken, Shirley Uitte de Willige   +7 more
doaj   +4 more sources

Acquired alpha‐2‐antiplasmin deficiency in acute promyelocytic leukaemia

British Journal of Haematology, 1988
We report a prospective study in nine consecutive adult patients with acute promyelocytic leukaemia (APL). The study objective was to assess the prevalence of activation of blood coagulation and/or activation of fibrinolysis in APL.
Giuseppe Avvisati, J W Ten Cate, A Sturk   +2 more
exaly   +4 more sources

Increased N‐terminal cleavage of alpha‐2‐antiplasmin in patients with liver cirrhosis [PDF]

Journal of Thrombosis and Haemostasis, 2013
Background The activity of alpha-2-antiplasmin (2AP), the main fibrinolytic inhibitor, is modified by N- and C-terminal proteolytic cleavages. C-terminal cleavage converts plasminogen-binding 2AP (PB-2AP) into a non-plasminogen-binding derivative.
Shirley Uitte De Willige, Frank W G Leebeek, D C Rijken   +2 more
exaly   +4 more sources

Evaluation of Fibrinolytic Inhibitors: Alpha-2-Antiplasmin and Plasminogen Activator Inhibitor 1 in Patients with Obstructive Sleep Apnoea. [PDF]

PLoS ONE, 2016
Obstructive sleep apnoea (OSA) induces thrombophilia and reduces fibrinolysis. Alpha-2-antiplasmin (a-2-AP) and plasminogen activator inhibitor 1 (PAI-1) are major inhibitors of the fibrinolytic system.
Maciej Zakrzewski, Ewelina Zakrzewska, Paweł Kiciński, Sylwia Przybylska-Kuć, Andrzej Dybała, Wojciech Myśliński, Jolanta Pastryk, Tomasz Tomaszewski, Jerzy Mosiewicz   +8 more
doaj   +2 more sources

Enhanced thrombin and plasmin generation profiles in alpha-2-antiplasmin–deficient patients: Data from the Rare Bleeding disorders in the Netherlands study [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: α2-Antiplasmin (A2AP) deficiency is a rare and often unidentified disorder characterized by increased fibrinolysis and subsequent bleeding. Global hemostasis assays may increase insight into the altered coagulation and fibrinolysis in these ...
Bauke Haisma, Sanna R. Rijpma, Marjon H. Cnossen, Paul L. den Exter, Ilmar C. Kruis, Karina Meijer, Laurens Nieuwenhuizen, Nick van Es, Roger E.G. Schutgens, Nicole M.A. Blijlevens, Waander L. van Heerde, Saskia E.M. Schols   +11 more
doaj   +2 more sources

Coping Styles and Defense Mechanisms in Healthy Young Adults—Correlations with tPA-BDNF Pathway [PDF]

Brain Sciences
Background/Objectives: An increasing number of studies are exploring how stress influences the development of various psychiatric and physical disorders. Psychological coping strategies and defense mechanisms play a vital role in managing stress. However,
Julia Pilecka, Jedrzej Wojciechowski, Weronika Bargiel, Maria Terczynska, Przemyslaw Zakowicz, Dawid Bojarski, Karolina Wasicka-Przewozna, Maria Skibinska   +7 more
doaj   +2 more sources

Trauma induced coagulopathy is limited to only one out of four shock induced endotheliopathy (SHINE) phenotypes among moderate-severely injured trauma patients: an exploratory analysis [PDF]

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background Trauma induced coagulopathy remains to be an important cause of high transfusion requirements and mortality and shock induced endotheliopathy (SHINE) has been implicated.
Pär I. Johansson, Martin Vigstedt, Nicola S. Curry, Ross Davenport, Nicole P. Juffermans, Simon J. Stanworth, Marc Maegele, Christine Gaarder, Karim Brohi, Jakob Stensballe, Hanne H. Henriksen, for the Targeted Action for Curing Trauma-Induced Coagulopathy (TACTIC) Collaborators   +11 more
doaj   +2 more sources

SARS-COV-2 causes significant abnormalities in the fibrinolysis system of patients: correlation between viral mutations, variants and thrombosis [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundCoronavirus disease (COVID-19) is reported as a complex disorder affecting multiple systems and coagulopathy that can cause mortality. In this study, we investigated the correlation of SARS-CoV-2 mutations found in blood samples with various ...
Esra’a Abudouleh, Tarek Owaidah, Tarek Owaidah, Fatimah Alhamlan, Fatimah Alhamlan, Arwa A. Al-Qahtani, Reem M. Aljowaie, Fatimah Al-Ghnnam, Marie Fe Bohol, Ahmed A. Al-Qahtani, Ahmed A. Al-Qahtani   +10 more
doaj   +2 more sources