Results 131 to 140 of about 622,381 (163)
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Sensitivity of alpha-amanitin to oxidation by a lactoperoxidase-hydrogen peroxide system
Toxicon, 2000Oxidation of alpha-amanitin - a potent hepatotoxin found in the mushroom Amanita phalloides - by a lactoperoxidase-hydrogen peroxide system was investigated by different techniques. (i). UV spectroscopy of the mixture after 24 h incubation reveals a significant decrease in the absorbance range characteristic of the putative reactive moiety of the toxin,
Antoaneta Zheleva, D Michelot
exaly +4 more sources
Biodistribution of radiolabeled alpha-amanitin in mice: An Investigation
ToxiconMushroom poisonings caused by Amanita phalloides are the leading cause of mushroom-related deaths worldwide. Alpha-Amanitin (α-AMA), a toxic substance present in these mushrooms, is responsible for the resulting hepatotoxicity and nephrotoxicity. The objective of our study was to determine the distribution of α-AMA in Balb/c mice by labeling with ...
Kubra Durkan +2 more
exaly +4 more sources
Aucubin: Potential Antidote For Alpha-Amanitin Poisoning
Journal of Toxicology: Clinical Toxicology, 1984Aucubin, an iridoid glucoside isolated from Aucuba japonica (Cornaceae), exhibited significant protective activity against alpha-amanitin intoxication in mice. When a single dose of aucubin was administered intraperitoneally, a 50% survival rate was obtained even when the treatment was withheld for 12 hr after alpha-amanitin administration.
L M, Chang, H S, Yun, Y S, Kim, J W, Ahn
exaly +3 more sources
Evaluation of the genotoxicity of alpha-amanitin in mice bone marrow cells
Toxicon, 2017Alpha-amanitin is a known cytotoxic substance found in some mushroom species including Amanita phalloides. Its main mechanism of action is to block the transcription, which can lead to cell death. Lack of reports on the genotoxicity of this toxin was an inspiration for undertaking this experiment.
B, Marciniak +2 more
exaly +3 more sources
Failure of N‐Acetylcysteine to reduce alpha amanitin toxicity
Journal of Applied Toxicology, 1992AbstractAcetaminophen undergoes toxic conversion in the liver to a free‐radical intermediary which binds to glutathione. N‐Acetylcysteine acts as a glutathione precursor when natural stores are depleted, and is an effective antidote for acetaminophen overdose.
S M, Schneider +2 more
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Toxicon, 2018
Amanitin-induced apoptosis is proposed to have a significant effect on the pathogenesis of liver damage. However, few reports have focused on proteome changes induced by α-amanitin (α-AMA). Here, we evaluated changes in mitochondrial proteins of hepatocytes in response to 2 μM α-AMA, a concentration at which α-AMA-induced cell damage could be rescued ...
Meichi Wang, Zuohong Chen, Ping Chen
exaly +3 more sources
Amanitin-induced apoptosis is proposed to have a significant effect on the pathogenesis of liver damage. However, few reports have focused on proteome changes induced by α-amanitin (α-AMA). Here, we evaluated changes in mitochondrial proteins of hepatocytes in response to 2 μM α-AMA, a concentration at which α-AMA-induced cell damage could be rescued ...
Meichi Wang, Zuohong Chen, Ping Chen
exaly +3 more sources
[Toxicity of alpha-amanitin on mice in vivo].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2010To study the toxic effect of alpha-amanitin from Amanita fungi on mice in vivo.The LD50 of alpha-amanitin was determined with intravenous and intraperitoneal injections of alpha-amanitin. The mice were then injected intravenously with LD50 dose of alpha-amanitin, and the viscera index was evaluated.
Mei, Cao +4 more
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Hemoperfusion with alpha-amanitin: an in vitro study.
The International journal of artificial organs, 1997The authors carried out sixteen hemoperfusions with alpha-amanitin in vitro in a closed system using active charcoal, Amberlite XAD-2 and Amberlite XAD-4 in hemoperfusion capsules. As a perfusion solution 4 liters of 0.9% NaCl solution was used. The alpha-amanitin concentration in the solution was 8.3 +/- 0.36 mg/L.
M, Mydlík +3 more
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Cell biology international reports, 1980
Spontaneous and EMS-induced alpha-amanitin-resistant Aedes albopictus cells have been isolated and characterized. Two mutant sublines, one of intermediate resistance (alpha A2) and the other highly resistant (Ama18) contained RNA polymerase II activity, the resistance of which in vitro to alpha-amanitin correlated well with the resistance of these ...
S J, Mento, V, Stollar
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Spontaneous and EMS-induced alpha-amanitin-resistant Aedes albopictus cells have been isolated and characterized. Two mutant sublines, one of intermediate resistance (alpha A2) and the other highly resistant (Ama18) contained RNA polymerase II activity, the resistance of which in vitro to alpha-amanitin correlated well with the resistance of these ...
S J, Mento, V, Stollar
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Stability of ricinine, abrine, and alpha-amanitin in finished tap water
Analytical Methods, 2013Ricinine and abrine are potential indicators of drinking water contamination by ricin and abrin, respectively. Simultaneous detection of ricinine and abrine, along with α-amanitin, another potential biotoxin water contaminant, is reportable through the use of automated sample preparation via solid phase extraction and detection using liquid ...
Jennifer S. Knaack +6 more
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