Results 41 to 50 of about 676,531 (303)

Optimisation of alpha-amylase inhibitor production in solid state fermentation

Frontiers in Pharmacology, 2023
Though not a known producer of alpha-amylase inhibitor, the potential of Streptomyces xinghaiensis AAI-2 to produce this important metabolite was assessed and the process optimised in solid substrate using response surface methodology.
O. A. Fatoki, A. A. Onilude, Y. A. Ekanola, C. T. Akanbi   +3 more
doaj   +1 more source

Dexime: A Selectively Enzyme‐Degradable Hydrogel for Protein Therapeutic Release

Advanced Materials, EarlyView.
A dextrin‐oxime hydrogel (dexime) is produced using ketone or aldehyde modified dextrin and tetra‐oxyamine modified poly(ethylene glycol). The rheological and mechanical properties of dexime are tunable. Dexime is injectable, cytocompatible, hydrolytically stable, and selectively degradable by α‐amylase.
Quinton E. A. Sirianni, Nitzan Letko Khait, Adam Forman, Edward A. Armstrong, Karim Fouad, Molly S. Shoichet   +5 more
wiley   +1 more source

Cloning strategies for the isolation of an a-amylase inhibitor/endochitinase gene from the seeds of Coix lachryma-jobi [PDF]

, 1993
The aim of this work was to isolate the gene encoding a bifunctional a-amylase inhibitor/endochitinase protein from the seeds of Coix lachryma-jobi, a tropical cereal.
Fairweather, Donna, Fairweather, D
core  

Estimation of alpha-amylase in smokers with and without leukoplakia and oral cancer—A comparative study

Journal of Indian Academy of Oral Medicine and Radiology, 2023
Background: Cigarette smoke releases free radicles that have deleterious effects on the oral mucosa including potentially malignant disorders and oral cancer. In response to cigarette smoking, salivary flow rate increases as a defense activity along with
Harshitha Akkinepally, M L Avinash Tejasvi, N Lakshmi Kavitha, Archana Pokala, Praveen Reddy, Vummadi Reddy Keerthi   +5 more
doaj   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Monitoring of In-Season Salivary Alpha Amylase Trends for Professional Australian Rules Footballers

, 2018
Salivary Alpha Amylase has been considered a surrogate biomarker of autonomic nervous system, and may be considered useful to highlight periods of physiological fatigue in athletes.
Coad, S., Wellman, A., Gray, B., McLellan, C.   +3 more
core   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

Assessing the Role of Salivary Alpha-Amylase in Dental Caries in Children aged 6–9 Years – A Cross-sectional Study

Journal of Integrated Health Sciences
Introduction: Salivary alpha-amylase is an enzymatic powerhouse, breaking down starch in food and whisking it away from the oral cavity. Its presence in the acquired enamel pellicle hints at involvement in the adhesion of α-amylase-binding bacteria. This
Monika Surana, Vandana Shah, Dhruval S. Acharya   +2 more
doaj   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source