Results 71 to 80 of about 948,383 (242)

Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS)

Journal of Asthma and Allergy, 2022
Rita Vaz-Rodrigues,1 Lorena Mazuecos,1 José de la Fuente1,2 1SaBio (Health and Biotechnology), Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ciudad Real, 13005, Spain; 2Department of Veterinary Pathobiology, Center for ...
Vaz-Rodrigues R, Mazuecos L, de la Fuente J   +2 more
doaj  

Quantitative Binding Assay for Measuring Specific IgG Antibodies to Alpha-Gal Using the Neoglycoprotein Gal-alpha-1,3-Gal-beta-1,4-Glcnac-Human Serum Albumin

, 2015
Tick bites are known to induce IgE production to alpha-gal. Elevated alpha-gal IgG1 compared to natural alpha-gal IgG2 production has been reported in alpha-gal IgE+ subjects. We here report further investigation of the relationship between alpha-gal IgG
Schuyler, Alexander J, Commins, Scott P, James, Hayley R, Rispens, Theo, Rönmark, Eva,, Workman, Lisa J, Perzanowski, Matthew S, Platts-Mills, Thomas A E   +7 more
core   +1 more source

Conversion of tumors into autologous vaccines by intratumoral injection of alpha-Gal glycolipids that induce anti-Gal/alpha-Gal epitope interaction [PDF]

, 2013
Anti-Gal is the most abundant antibody in humans, constituting 1% of immunoglobulins. Anti-Gal binds specifically alpha-gal epitopes (Galalpha1-3Galbeta1-4GlcNAc-R).
Galili, Uri
core   +1 more source

SIZ1‐Mediated SUMOylation of LBD29 Recruits ARF7 to Fine‐Tune Auxin Signaling in Lateral Root Development

Advanced Science, EarlyView.
Our findings establish SUMOylation as a key post‐translational control layer in auxin signaling. We show that SIZ1‐mediated SUMOylation of LBD29 promotes its association with ARF7, stabilizing a transcriptional hub that governs lateral root development.
Jiaxuan Sui, Qianlan Yin, Yiying Chen, Liping Zhang, Xiuyuan Yu, Qianqian Yu, Zhaojun Ding, Xiangpei Kong   +7 more
wiley   +1 more source

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source

Gal-9 epitope recognition by Gal-Nab1 and Gal-Nab2.

, 2018
A. Apoptotic cell death assessed by flow cytometry in CD3+ T cells treated for 36h with gal-9 (gal-9S; 40 nM) alone or in combination with mAbs (ctrl IgG1, Gal-Nab1, Gal-Nab2; 67 nM) pre-incubated or not with scramble peptide (Scr.) or gal-9 CTB-peptide (
Olivier Morales (5738711), Aurore Gelin (243644), Masaki Ueno (121130), Pierre Busson (40733), Valentin Baloche (5738702), Olivier Dellis (5738714), Toshiro Niki (121127), Nadira Delhem (332865), Laetitia Claër (832691), Rami Mustapha (5738705), Clément Barjon (5738699), Ming Wei (466751), Sylviane Hoos (156503), Yoichi Chiba (5738708), Mitsuomi Hirashima (68149), Bertrand Raynal (152084), Claire Lhuillier (5738696)   +16 more
core   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Herbicide Metabolic Resistance in Poaceae Plants via the GA‐GID1/DELLA‐DOF2‐P450s Module

Advanced Science, EarlyView.
Plant hormone signaling modulates herbicide resistance in Echinochloa crus‐galli. The GA–DELLA–DOF2 cascade directly activates P450 detoxification genes in two Poaceae species, uncovering a core mechanism of metabolic herbicide resistance. ABSTRACT Barnyard grass (Echinochloa crus‐galli) is one of the world's most important weeds, and the evolution of ...
Junzhi Wang, Jiale Qi, Lin Wei, Qin Yu, Zhongyuan Liu, Lianyang Bai, Lang Pan   +6 more
wiley   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source