Results 31 to 40 of about 2,027,296 (190)

Ascaris lumbricoides and ticks associated with sensitization to galactose α1,3-galactose and elicitation of the alpha-gal syndrome [PDF]

, 2021
BACKGROUND: IgE to galactose alpha-1,3 galactose (alpha-gal) causes alpha-gal syndrome (delayed anaphylaxis after ingestion of mammalian meat). Development of sensitization has been attributed to tick bites; however, the possible role of other parasites ...
Cunningham, Stephen, Falcone, Franco H, Moreira, Bernardo Pereira, Facey-Thomas, Heidi, Halajian, Ali, Joshi, Lokesh, Murangi, Tatenda, Botha, Maresa, Levin, Michael E, Prakash, Prema, Basera, Wisdom, Horsnell, William, Ramjith, Jordache   +12 more
core   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

A dataset for the analysis of antibody response to glycan alpha-Gal in individuals with immune-mediated disorders [version 2; peer review: 2 approved, 1 not approved]

F1000Research, 2021
Humans evolved by losing the capacity to synthesize the glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), which resulted in the development of a protective response mediated by anti-α-Gal IgM/IgG/IgA antibodies against pathogens containing this modification on ...
José de la Fuente, José Miguel Urra, Marinela Contreras, Iván Pacheco, Elisa Ferreras-Colino, Ernesto Doncel-Pérez, Isabel G. Fernández de Mera, Margarita Villar, Carmen M. Cabrera, Cesar Gómez Hernando, Eduardo Vargas Baquero, Javier Blanco García, Javier Rodríguez Gómez, Alberto Velayos Galán, Francisco Feo Brito, Elisa Gómez Torrijos, Alejandro Cabezas-Cruz, Christian Gortázar   +17 more
doaj   +1 more source

Rare food allergies - alpha-gal syndrome [PDF]

, 2023
Introducere. Sindromul alfa-gal este o reacție alergică rară la carnea roșie. Apare în urma înțepăturii de căpușă, prin producerea de IgE specifice către epitopul galactoză-α-1,3-galactoză, dar se asociază și cu valori majorate ale IgE specifice către
Brocovschii, Victoria, Cemirtan, Svetlana, Chiosa, Mihaela   +2 more
core   +1 more source

Perioperative Outcomes After Bioprosthetic Valve Replacement in Patients Sensitized to Alpha-Gal

Annals of Thoracic Surgery Short Reports
Background: Alpha-gal syndrome from tick bites, due to sensitivity to alpha-gal, can cause severe allergies. Heart valve implants contain alpha-gal, yet alpha-gal syndrome screening is not standard before valve replacement.
Berk Aykut, MD, Hoe King Lim, BEng, Smith M. Ngeve, BA, Anna Hoover, BS, Cathlyn K. Medina, BA, Jacob Scherba, BS, Ashley Menken, BS, Douglas M. Overbey, MD, MPH, Tariq M. Omer, MS, Scott P. Commins, MD, PhD, Joseph R. Nellis, MD, MBA, Joseph W. Turek, MD, PhD   +11 more
doaj   +1 more source

Allergic reactions to tick saliva components in zebrafish model

Parasites & Vectors, 2023
Background Alpha-Gal syndrome (AGS) is a tick-borne food allergy caused by IgE antibodies against the glycan galactose-alpha-1,3-galactose (α-Gal) present in glycoproteins and glycolipids from mammalian meat.
Marinela Contreras, Rita Vaz-Rodrigues, Lorena Mazuecos, Margarita Villar, Sara Artigas-Jerónimo, Almudena González-García, Nadezhda V. Shilova, Nicolai V. Bovin, Sandra Díaz-Sánchez, Elisa Ferreras-Colino, Iván Pacheco, Jindřich Chmelař, Petr Kopáček, Alejandro Cabezas-Cruz, Christian Gortázar, José de la Fuente   +15 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Alpha Gal in the Preoperative Environment [PDF]

, 2023
Background: Alpha gal syndrome (AGS) is an allergy acquired from the bite of the lone star tick. This allergy manifests as a sensitivity to red meat, medicines, and implants derived from mammalian sources.
Everding, Grant, NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Recently Evolved Francisella-Like Endosymbiont Outcompetes an Ancient and Evolutionarily Associated Coxiella-Like Endosymbiont in the Lone Star Tick (Amblyomma americanum) Linked to the Alpha-Gal Syndrome

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundTicks are hematophagous arthropods that transmit various bacterial, viral, and protozoan pathogens of public health significance. The lone star tick (Amblyomma americanum) is an aggressive human-biting tick that transmits bacterial and viral ...
Deepak Kumar, Surendra Raj Sharma, Abdulsalam Adegoke, Ashley Kennedy, Holly C. Tuten, Andrew Y. Li, Shahid Karim, Shahid Karim   +7 more
doaj   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source