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Tick salivary gland extract induces alpha‐gal syndrome in alpha‐gal deficient mice [PDF]

Immunity, Inflammation and Disease, 2021
Introduction Alpha‐gal syndrome (AGS) is characterized by delayed hypersensitivity to non‐primate mammalian meat in people having specific immunoglobulin E (sIgE) to the oligosaccharide galactose‐alpha‐1,3‐galactose.
Shailesh K. Choudhary, Shahid Karim, Onyinye I. Iweala, Shivangi Choudhary, Gary Crispell, Surendra Raj Sharma, Claire T. Addison, Mike Kulis, Brian H. Herrin, Susan E. Little, Scott P. Commins   +10 more
doaj   +3 more sources

Evolution of alpha-Gal synthesis - a growing risk for alpha Gal syndrome [PDF]

Annals of Medicine
Background Alpha-Gal syndrome (AGS) is a growing burden worldwide associated with arthropods and allergies with pathologies such as urticaria, digestive and anaphylactic reactions. These reactions commonly appear 2–6 h after consumption of mammalian meat
Rita Vaz-Rodrigues, José de la Fuente
doaj   +2 more sources

Differential alpha-gal expression during Amblyomma hebraeum and Rhipicephalus evertsi tick feeding and development: A driver for the development of alpha-gal syndrome in South Africa [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: The presence of galactose-α-1,3-galactose (alpha-gal) in tick salivary antigens has been implicated to initiate host IgE responses resulting in sensitization to alpha-gal.
Tatenda Murangi, PhD, Ben Mans, PhD, Ronel Pienaar, PhD, Maresa Botha, MD, Heidi Facey-Thomas, DipNursCert, Stephen Cunningham, PhD, Ali Halajian, PhD, Lokesh Joshi, PhD, Franco H. Falcone, PhD, William Horsnell, PhD, Michael E. Levin, PhD   +10 more
doaj   +2 more sources

Alpha-gal sensitization and allergic transfusion reactions: a scoping review protocol [PDF]

Systematic Reviews
Background Tick bites may expose individuals to a carbohydrate not found in humans, galactose-alpha-1,3-galactose (alpha-gal). A spectrum of disorders may result from IgE-mediated hypersensitivity reactions to alpha-gal, including alpha-gal syndrome (AGS)
Maureen J. Miller, Carrie Price, Tracy C. Shields, Roya Zarpak, Patricia Lee, Zachary Osterwind, Mattias Lenz, Mirna Argueta Guevara, Sarah Fowler, Alicia A. Livinski, Valeria De Giorgi   +10 more
doaj   +2 more sources

Nutritional considerations for alpha-gal syndrome: a mini-review [PDF]

Frontiers in Allergy
Alpha-gal syndrome (AGS) is an immunoglobulin E-mediated sensitivity to galactose-alpha-1,3-galactose (“alpha-gal”), an oligosaccharide found in non-primate, mammalian-derived foods and products as well as some plant-based ingredients.
Abbigail Pace, Heather Norman-Burgdolf, Anna Cason   +2 more
doaj   +2 more sources

Alpha-gal sensitization and allergic blood transfusion reactions: a scoping review [PDF]

Journal of Translational Medicine
Background Tick bites may expose individuals to a carbohydrate not found in humans, galactose-alpha-1,3-galactose (alpha-gal), including allergy to mammalian red meat or red meat-derived products presenting 2–6 hours after consuming the product plus ...
Maureen J. Miller, Roya Zarpak, Patricia Lee, Zachary Osterwind, Mattias Lenz, Mirna Argueta Guevara, Sarah Fowler, Carrie Price, Tracy C. Shields, Alicia A. Livinski, Kathleen Conry-Cantilena, David F. Stroncek, Kamille West-Mitchell, Valeria De Giorgi   +13 more
doaj   +2 more sources

Alpha-Gal Syndrome: Involvement of Amblyomma americanum α-D-Galactosidase and β-1,4 Galactosyltransferase Enzymes in α-Gal Metabolism

Frontiers in Cellular and Infection Microbiology, 2021
Alpha-Gal Syndrome (AGS) is an IgE-mediated delayed-type hypersensitivity reaction to the oligosaccharide galactose-α-1, 3-galactose (α-gal) injected into humans from the lone-star tick (Amblyomma americanum) bite. Indeed, α-gal is discovered in salivary
Surendra Raj Sharma, Gary Crispell, Ahmed Mohamed, Cameron Cox, Joshua Lange, Shailesh Choudhary, Scott P. Commins, Shahid Karim, Shahid Karim   +8 more
doaj   +3 more sources

Tick bite-induced alpha-gal syndrome and immunologic responses in an alpha-gal deficient murine model

Frontiers in Immunology
IntroductionAlpha-Gal Syndrome (AGS) is a delayed allergic reaction due to specific IgE antibodies targeting galactose-α-1,3-galactose (α-gal), a carbohydrate found in red meat.
Surendra Raj Sharma, Shailesh K. Choudhary, Julia Vorobiov, Scott P. Commins, Shahid Karim   +4 more
doaj   +3 more sources

Alpha-gal allergy in a South Asian country [PDF]

BMC Immunology
Background Alpha gal syndrome (AGS) is a delayed allergy to red meat, due to IgE to galactose-alpha-1,3-galactose (alpha-gal). Sensitization occurs via tick bites.
Dhanushka Dasanayake, Chandima Karunatilake, Chathurika Karunaratne, Nishadini Fernando, Janitha Iddagoda, Rajiva de Silva   +5 more
doaj   +2 more sources

Single-cell mRNA analysis and surface marker expression profiling of circulating immune cells in humans with alpha-gal syndrome [PDF]

Frontiers in Immunology
IntroductionAlpha-gal syndrome (AGS) is an IgE-mediated allergy to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). Alpha-gal is found in the tissues of non-catarrhine mammals, and the characteristic delayed reactions are caused by the ...
Shailesh K. Choudhary, Scott P. Commins, Scott P. Commins, Scott P. Commins   +3 more
doaj   +2 more sources