Results 31 to 40 of about 948,383 (242)

Normal human serum contains high levels of anti-Gal alpha 1-4GlcNAc antibodies

, 2007
BACKGROUND: Natural xenoreactive antibodies (Abs) directed against the Bdi-epitope (Gal alpha 1-3Gal beta) on the cells of non-primate mammals take part in hyperacute rejection of xenotransplanted organs.
Obukhova, Polina, Bovin, Nicolai, Rieben, Robert   +2 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A protocol for pre-treatment testing for antibodies to galactose-alpha-1,3-galactose to mitigate the risk of cetuximab hypersensitivity reactions – a retrospective cohort review

Cancer Treatment and Research Communications
Purpose: Cetuximab improves survival in KRAS wildtype metastatic colorectal cancer. However, high rates of hypersensitivity reactions (HSRs) limit its use, with HSR rates up to 10–20 %.
Nicholas Della Marta, Alexander Yuile, Claire Mok, Joe Wei, Meredith Oatley, Tracey Skinner, Samuel Miller, Amanda L. Hudson, Sheryl van Nunen, Stephen J. Clarke, Connie I. Diakos, Madhawa De Silva, David L. Chan, Gavin M. Marx, Nick Pavlakis   +14 more
doaj   +1 more source

Patients’ Health Information Practices and Perceptions of Provider Knowledge in the Case of the Newly Discovered Alpha-gal Food Allergy

Journal of Patient Experience, 2020
Background: Alpha-gal food allergy is a life-threatening, newly discovered condition with limited presence in authoritative information sources. Sufferers seeking diagnosis are likely to encounter clinicians unfamiliar with the condition.
Mary Grace Flaherty PhD, MLS, MS, Megan Threats PhD(c), Samantha J. Kaplan PhD, MLIS   +2 more
doaj   +1 more source

Altered Blood Levels of Anti-Gal Antibodies in Alzheimer’s Disease: A New Clue to Pathogenesis?

Life, 2021
Alzheimer’s disease is a neurodegenerative disorder whose pathological mechanisms, despite recent advances, are not fully understood. However, the deposition of beta amyloid -peptide and neuroinflammation, which is probably aggravated by dysbiotic ...
Antonella Angiolillo, Alessandro Gandaglia, Alessia Arcaro, Andrea Carpi, Fabrizio Gentile, Filippo Naso, Alfonso Di Costanzo   +6 more
doaj   +1 more source

GAL-Repository/SARS-CoV-2_BW.1: v1.0.1

, 2022
Full Changelog: https://github.com/GAL-Repository/SARS-CoV-2_BW.
Xaira Rivera, GAL-Repository, Rodrigo García-López   +2 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Ingestion of mammalian meat and alpha-gal allergy: Clinical relevance in primary care

African Journal of Primary Health Care & Family Medicine, 2019
Background: An allergic reaction to mammalian meat has recently been reported in rural parts of South Africa and throughout other parts of the world. The cause of this allergic reaction is because of an oligosaccharide antigen known as galactose-alpha-1,
Tshegofatso Mabelane, Gboyega A. Ogunbanjo   +1 more
doaj   +1 more source

Biomarker discovery in galactosemia: Metabolomics with UPLC/HRMS in dried blood spots

Frontiers in Molecular Biosciences, 2023
Introduction:Galactosemia (GAL) is a genetic disorder that results in disturbances in galactose metabolism and can lead to life-threatening complications. However, the underlying pathophysiology of long-term complications in GAL remains poorly understood.
Ahmad N. Alodaib, Ahmad N. Alodaib, Refat M. Nimer, Rowan Alhumaidy, Alaa Alhenaky, Mai Abdel Jabar, Reem H. AlMalki, Reem H. AlMalki, Anas M. Abdel Rahman, Anas M. Abdel Rahman   +9 more
doaj   +1 more source