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Alpha-Gal Syndrome after Ixodes scapularis Tick Bite and Statewide Surveillance, Maine, USA, 2014–2023 [PDF]

Emerging Infectious Diseases
In the United States, alpha-gal syndrome (AGS) is primarily associated with lone star tick (Amblyomma americanum) bites. We describe AGS onset after an Ixodes scapularis tick bite and present AGS surveillance in Maine, 2014–2023.
Eleanor F. Saunders, Haris Sohail, Devin J. Myles, Dawn Charnetzky, Bryan N. Ayres, William L. Nicholson, Scott P. Commins, Johanna S. Salzer   +7 more
doaj   +2 more sources

Is Zebrafish a Good Model for the Alpha-Gal Syndrome? [PDF]

FASEB J
The alpha-Gal syndrome (AGS) is an underdiagnosed tick-borne allergy characterized by both immediate and delayed IgE-mediated anaphylactic reactions to the galactose-alpha-1,3-galactose (alpha-Gal) epitope. Common manifestations include gastrointestinal,
Vaz-Rodrigues R, de la Fuente J.
europepmc   +2 more sources

Alpha-gal syndrome: the first report in Poland

Central European Journal of Immunology, 2021
Alpha-gal syndrome is an immunoglobulin E (IgE)-dependent allergy to galactose--1,3-galactose, resulting in a delayed anaphylactic reaction to red meat.
Mirella Brzozowska, Natalia Mokrzycka, Grzegorz Porębski   +2 more
doaj   +1 more source

Alpha-gal syndrome initially misdiagnosed as chronic spontaneous urticaria in a pediatric patient: a case report and review of the literature

Journal of Medical Case Reports, 2023
Introduction Delayed allergy to red meat, also termed alpha-gal syndrome, is increasingly reported in adults and African communities, while pediatric cases remain rare.
Felicitas Bellutti Enders, Marius Elkuch, Andreas Wörner, Kathrin Scherer Hofmeier, Karin Hartmann   +4 more
doaj   +1 more source

Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model

Frontiers in Cellular and Infection Microbiology, 2020
Ticks are arthropod ectoparasite vectors of pathogens and the cause of allergic reactions affecting human health worldwide. In humans, tick bites can induce high levels of immunoglobulin E antibodies against the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α ...
Marinela Contreras, Iván Pacheco, Pilar Alberdi, Sandra Díaz-Sánchez, Sara Artigas-Jerónimo, Lourdes Mateos-Hernández, Lourdes Mateos-Hernández, Margarita Villar, Alejandro Cabezas-Cruz, José de la Fuente, José de la Fuente   +10 more
doaj   +1 more source

Tick Intrastadial Feeding and Its Role on IgE Production in the Murine Model of Alpha-gal Syndrome: The Tick “Transmission” Hypothesis

Frontiers in Immunology, 2022
Recent studies have provided strong evidence indicating that lone star tick bites are a cause of AGS (alpha-gal syndrome, also known as red meat allergy RMA) in humans.
L. Paulina Maldonado-Ruiz, Gunavanthi D. Boorgula, Donghun Kim, Sherry D. Fleming, Yoonseong Park   +4 more
doaj   +1 more source

The Meat of the Matter: Understanding and Managing Alpha-Gal Syndrome

ImmunoTargets and Therapy, 2022
Jessica D Macdougall,1,2,* Kevin O Thomas,1,2,* Onyinye I Iweala1,2 1Department of Medicine, Thurston Arthritis Research Center, Division of Rheumatology, Allergy, and Immunology, Chapel Hill, NC, 27599, USA; 2Department of Pediatrics, University
Macdougall JD, Thomas KO, Iweala OI
doaj  

The alpha-Gal Syndrome is Underdiagnosed

, 2023
Refers to: The alpha-Gal Syndrome is Underdiagnosed; Actas Dermo-Sifiliográficas, Volume 115, Issue 1, January 2024, Pages 116-117; J.
J. de la Fuente, Fuente, José de la
core   +1 more source

Alpha-Gal Syndrome: Involvement of Amblyomma americanum α-D-Galactosidase and β-1,4 Galactosyltransferase Enzymes in α-Gal Metabolism

Frontiers in Cellular and Infection Microbiology, 2021
Alpha-Gal Syndrome (AGS) is an IgE-mediated delayed-type hypersensitivity reaction to the oligosaccharide galactose-α-1, 3-galactose (α-gal) injected into humans from the lone-star tick (Amblyomma americanum) bite. Indeed, α-gal is discovered in salivary
Surendra Raj Sharma, Gary Crispell, Ahmed Mohamed, Cameron Cox, Joshua Lange, Shailesh Choudhary, Scott P. Commins, Shahid Karim, Shahid Karim   +8 more
doaj   +1 more source

Diagnostic validity of specific immunoglobulin E levels to alpha-gal in alpha-gal syndrome: a cross-sectional analysis

Allergy, Asthma & Clinical Immunology, 2023
Background The diagnosis of Alpha-gal Syndrome (AGS) is based on the presence of symptoms after being exposed to potential sources of alpha-gal together with values ​​of specific IgE (sIgE) to alpha-gal ≥ 0.1 kUA/L or ≥ 0.35 kUA/L.
Adrián Germán-Sánchez, Ana Alonso-Llamazares, Fernando García-González, Bakai Matala-Ahmed, Ceny Solani Melgar-Reyes, Ignacio Antepara-Ercoreca   +5 more
doaj   +1 more source