Results 41 to 50 of about 46,608 (304)

Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities, Molecular Docking, and Antioxidant Capacities of Plectranthus ecklonii Constituents

Antioxidants, 2022
Shortage in insulin secretion or degradation of produced insulin is the principal characteristic of the metabolic disorder of diabetes mellitus (DM). However, because the current medications for the treatment of DM have many detrimental side effects, it ...
Ninon G. E. R. Etsassala, Jelili A. Badmus, Jeanine L. Marnewick, Samuel Egieyeh, Emmanuel. I. Iwuoha, Felix Nchu, Ahmed A. Hussein   +6 more
doaj   +1 more source

Alpha glucosidase inhibition activity of phenolic fraction from Simarouba glauca: An in-vitro, in-silico and kinetic study

Heliyon, 2020
A phenolic rich fraction purified from Simarouba glauca leaves was effective in alpha glucosidase inhibition. The purified fraction named ‘fraction-14’ had shown significant inhibition of yeast alpha glucosidase enzyme activity (IC50 = 2.4 ± 0.4 μg/mL ...
Kirana P. Mugaranja, Ananda Kulal
doaj   +1 more source

Cardiac outcome in classic infantile Pompe disease after 13\xe2\x80\xafyears of treatment with recombinant human acid alpha-glucosidase [PDF]

, 2018
Background: Cardiac failure is the main cause of death in untreated classic infantile Pompe disease, an inheritable metabolic myopathy characterized by progressive hypertrophic cardiomyopathy.
Capelle, C.I. (Carine) van, Cools, B. (Bjorn), Frohn-Mulder, I.M.E. (Ingrid), Helbing, W.A. (Willem), Hout, J.M.P. (Johanna) van den, Koopman, L.P. (Laurens), Ploeg, A.T. (Ans) van der, Poelman, E. (Esther), R\xc3\xa9gal, L. (Luc)   +8 more
core   +1 more source

Screening of Alpha-Glucosidase and Alpha-Amylase Inhibitors in the Descurainia Sophia Flower by Molecular Docking to Prevention the Progression of Diabetes [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Alpha-amylase and alpha-glucosidase enzymes raise blood glucose levels by breaking down complex polysaccharide units into absorbable monosaccharide units. The aim of this study was to investigate the inhibitory effect of compounds
Morteza Sadeghi
doaj  

In-Vivo Alpha-Amylase and Alpha-Glucosidase Inhibitory Activities of Solanum anomalum Leaf Extract and Fractions

Biology, Medicine & Natural Product Chemistry, 2023
Solanum anomalum Thonn. ex Schumach. (family Solanaceae), an edible shrub whose fruits and leaves are used medicinally to treat diseases including diabetes was evaluated for effect on alpha amylase and alpha glucosidase enzymes in vivo. The leaf extract (
Jude Efiom Okokon, Idongesit Charles Etuk, John Akpan Udobang, Nwakaego Omonigho Ebong   +3 more
doaj   +1 more source

Assessment of in vitro alpha-glucosidase inhibitory activity, phenolics, flavonoidsand antioxidant potential of jamun (Syzygium cumini) seeds

Journal of Horticultural Sciences
Jamun (Syzygium cumini Linn. Syn. Eugenia jambolana) genotypes collected from different parts of the country were evaluated for in vitro alpha-glucosidase inhibitory activity, polyphenolic content and antioxidant potential along with fruit characters ...
Arivalagan M, Priyanka DR, Rekha A, Tripathi PC   +3 more
doaj   +1 more source

Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease

EMBO Molecular Medicine, 2021
Pompe disease is a metabolic myopathy due to acid alpha‐glucosidase deficiency. In addition to glycogen storage, secondary dysregulation of cellular functions, such as autophagy and oxidative stress, contributes to the disease pathophysiology.
Antonietta Tarallo, Carla Damiano, Sandra Strollo, Nadia Minopoli, Alessia Indrieri, Elena Polishchuk, Francesca Zappa, Edoardo Nusco, Simona Fecarotta, Caterina Porto, Marcella Coletta, Roberta Iacono, Marco Moracci, Roman Polishchuk, Diego Luis Medina, Paola Imbimbo, Daria Maria Monti, Maria Antonietta De Matteis, Giancarlo Parenti   +18 more
doaj   +1 more source

Effects of a higher dose of alglucosidase alfa on ventilator-free survival and motor outcome in classic infantile Pompe disease: an open-label single-center study [PDF]

, 2016
Background: Though enzyme-replacement therapy (ERT) with alglucosidase alfa has significantly improved the prospects for patients with classic infantile Pompe disease, some 50 % of treated infants do not survive ventilator-free beyond the age of 3 years.
Beek, N.A.M.E. (Nadine) van der, Hoogeveen-Westerveld, M. (Marianne), Ploeg, A.T. (Ans) van der, Plug, I. (Iris), Poelman, E. (Esther), Reuser, A.J.J. (Arnold), Van Gelder, C.M. (Carin)   +6 more
core   +1 more source

Identification of Compounds and Antidiabetic Activities of the Ethyl Acetate Fraction of Yacon (Smallanthus sonchifolius) Leaves using In Silico and In Vitro Approaches

Majalah Obat Tradisional, 2023
Yacon (Smallanthus sonchifolius) is a plant that is vastly cultivated in Indonesia and has anti-diabetic activity. The purpose of this study was to isolate the compounds from the semipolar fraction of yacon leaves, as well as test them in silico and in ...
Binar Pratama, Tatang Irianti, Hari Purnomo   +2 more
doaj   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source