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Age-dependence of alpha-MSH-induced anorexia

Neuropeptides, 2010
Long-term regulation of energy balance involves two major trends: first age-related obesity develops in the middle-aged, later it is followed by anorexia of aging (sarcopenia and/or cachexia). A dynamic balance between orexigenic and anorexigenic neuropeptides is essential for the regulation of energy homeostasis.
E, Pétervári   +4 more
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Ingested (oral) alpha-MSH inhibits acute EAE

Journal of Neuroimmunology, 2008
Ingested type I IFN and SIRS peptide administered orally inhibit EAE. We examined whether another immunoactive protein, tridecapeptide alpha-MSH, would have similar anti-inflammatory effects in EAE after oral administration. B6 mice were immunized with MOG peptide 35-55 and gavaged with 0.1 ml of control saline or alpha-MSH peptide starting on day -7 ...
Staley A, Brod, Zachary M, Hood
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ALPHA-MSH STIMULATION OF GROWTH HORMONE RELEASE

The Journal of Clinical Endocrinology & Metabolism, 1973
The tridecapeptide 1–13 of human ACTH (∞-MSH) was found to induce GH release in 18 among 23 normal males ; peak values occurred at 30 or 45 min. ∞-MSH was given IV over 1 min at a dose of 0.5 mg. No change in blood cortisol or glucose were found while minimal side effects occurred in only 4 subjects. GH did not rise after placebo injection.
G, Strauch   +3 more
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Acute phase response to endotoxin: rise in plasma alpha-MSH and effects of alpha-MSH injection

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1990
Endotoxins, cell wall components of bacteria, cause a number of biological effects, presumably via induction of potent cytokines. Previous research suggests that the neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) and its COOH-terminal tripeptide reduce the effects of cytokines.
L W, Martin, J M, Lipton
openaire   +2 more sources

Alpha-MSH peptides inhibit acute inflammation and contact sensitivity

Peptides, 1990
Alpha-melanocyte stimulating hormone [alpha-MSH(1-13)] occurs within the CNS, skin, circulation and in other body sites. This tridecapeptide and its COOH-terminal tripeptide, alpha-MSH (11-13), have antipyretic and anti-inflammatory actions. Studies of the anti-inflammatory effects of these molecules have been confined mainly to tests of inhibition of ...
M E, Hiltz, J M, Lipton
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Alpha-MSH regulates protein ubiquitination in T cells.

Cellular and molecular biology (Noisy-le-Grand, France), 2006
The neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) suppresses IFN-gamma + T cells from mice. We discovered, however, that despite this significant production by DTH-mediating effector CD4 supression of IFN-gamma production, alpha-MSH-treated effector T cells had the same level of IFN-gamma mRNA expression and intracellular IFN-gamma ...
D J, Biros, K, Namba, A W, Taylor
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Alpha MSH-induced excessive grooming behavior involves a GABAergic mechanism

Peptides, 1991
It has been shown that MSH administered in the ventral tegmental area (VTA) elicits excessive grooming behavior (EGB) by stimulating an acetylcholinergic pathway. The present work was performed in order to evaluate the possible participation of the GABAergic system in this behavior. VTA injection of GABA antagonist bicuculline stimulated the EGB (55.5 +
S R, De Barioglio   +2 more
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alpha-MSH and desacetyl-alpha-MSH signaling through melanocortin receptors.

Annals of the New York Academy of Sciences, 2003
The functional significance of N-terminal acetylation of ACTH[1-13]NH(2) is unknown. N-terminal acetylation of ACTH[1-13]NH(2) (known as desacetyl-alpha-MSH) to produce alpha-MSH enhances some activities of ACTH[1-13]NH(2) and virtually eliminates others.
Kathleen G, Mountjoy   +3 more
openaire   +1 more source

Des-acetyl-alpha-MSH and not alpha-MSH is the major form of alpha-MSH in amniotic fluid.

Journal of endocrinological investigation, 1988
Immunoreactive alpha-melanocyte stimulating hormone (IR-alpha-MSH)-like activity was measured by radioimmunoassay (RIA) in at term pregnancy amniotic fluid prior and after adsorption on a Sep-pak C18 cartridge. alpha-MSH activity was 3-4 times lower after Sep-pak purification but, unlike the levels of IR-alpha-MSH in the fluid analyzed in toto ...
A, Mauri   +9 more
openaire   +1 more source

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