Results 71 to 80 of about 8,015 (172)

The Importance of Melanocortin Receptors and Their Agonists in Pulmonary Disease

Frontiers in Medicine, 2019
Melanocortin agonists are ancient neuropeptides that have steroidogenesis and anti-inflammatory properties. They activate melanocortin receptors (MCR), a family of five seven-transmembrane G-protein coupled receptors. MC1R and MC3R are mainly involved in
Anna Elizabeth Moscowitz, Huda Asif, Laurence Baily Lindenmaier, Andrew Calzadilla, Chongxu Zhang, Mehdi Mirsaeidi, Mehdi Mirsaeidi   +6 more
doaj   +1 more source

Melanin Metabolism: A Novel Oxidative Degradation Mechanism and Regulation by Hydrolyzed Conchiolin Protein

Journal of Cosmetic Dermatology, Volume 25, Issue 3, March 2026.
ABSTRACT Background Most pharmacological depigmenting agents and cosmetic skin‐brightening products achieve their effects by suppressing melanogenesis. However, the fate of melanin after melanosome transfer to keratinocytes—and the mechanisms governing its intracellular clearance—remains insufficiently explored.
Xinyi Zhao, Haifeng Zeng, Long Zhu, Lihao Gu   +3 more
wiley   +1 more source

Effects of Polyethylene Glycol and 8-Aminooctanoic Acid Linkers on Melanoma Uptake of [^99mTc]Tc-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized α-MSH Peptides. [PDF]

Bioconjug Chem, 2023
Qiao Z, Xu J, Gonzalez R, Miao Y.
europepmc   +1 more source

Impact of long‐term maternal high‐fat, high‐sugar feeding on gastric vagal afferent responses and feeding behaviour in mouse offspring

Experimental Physiology, Volume 111, Issue 3, Page 1330-1339, 1 March 2026.
Abstract Poor maternal nutrition and excessive gestational weight gain predict future development of obesity in offspring. Preclinically, maternal obesity induced by a high‐fat, high‐sugar diet (HFHSD) induces hyperphagia and obesity in offspring. We hypothesized that this might, in part, reflect reduced peripheral gastric vagal afferent (GVA) satiety ...
Georgia S. Clarke, Hui Li, Elaheh Heshmati, Kelly M. Gembus, Stephanie E. O'Hara, Lisa M. Nicholas, Kathryn L. Gatford, Amanda J. Page   +7 more
wiley   +1 more source

Probing the Role of Melanocortin Type 1 Receptor Agonists in Diverse Immunological Diseases

Frontiers in Pharmacology, 2019
Background: The melanocortin α-melanocyte stimulating hormone (α-MSH), an endogenous peptide with high affinity for the melanocortin 1 receptor (MC1r), has demonstrated prevention and reversal of intestinal and ocular inflammation in animal models ...
Carl Spana, Andrew W. Taylor, David G. Yee, Marie Makhlina, Wei Yang, John Dodd   +5 more
doaj   +1 more source

The Formation of Covalent Linkages in Lignocellulosic Biomass via the Oxocarbenium Intermediate

ChemPhysChem, Volume 27, Issue 4, 25 February 2026.
Density functional theory models show that the hydrated and acidic hemicellulose matrix in lignocellulosic biomass can generate oxocarbenium ions. These reactive intermediates can participate in the stable formation of glycosidic lignin‐carbohydrate covalent linkages, promoting recalcitrance in plant biomass.
Eduardo Romero‐Montalvo, Samir H. Mushrif   +1 more
wiley   +1 more source

A mixture of seaweed extracts and glycosaminoglycans from sea squirts inhibits α-MSH-induced melanogenesis in B16F10 melanoma cells

Fisheries and Aquatic Sciences, 2019
Background In the present study, the skin-whitening effects of a marine-sourced mixture that includes a fucoidan-rich extract of Undaria pinnatifida (UPEF), a phlorotannin-rich extract of Ecklonia cava (ECE), and glycosaminoglycans (GAGs) from sea squirt
Lei Wang, Yong Ri Cui, Hye-Won Yang, Hyo Geun Lee, Ju-Young Ko, You-Jin Jeon   +5 more
doaj   +1 more source

Effects of alpha-MSH on corneal epithelial lesions in rats.

Collegium antropologicum, 2012
We investigated the influence of alpha-melanocyte stimulating hormone (alpha-MSH) on the healing of corneal epithelial lesions in male Wistar rats. The lesions were induced by abrading corneal epithelium with a surgical lancet under a biomicroscope. Before the abrasion corneal epithelium was softened with 40% ethanol. alpha-MSH drops in a concentration
Pavan, Josip, Lukenda, Adrian, Stambuk, Nikola, Konjevoda, Pasko, Kastelan, Snjezana, Curkovic, Marko   +5 more
openaire   +4 more sources

Origins of Noncovalent Interactions in Lignocellulosic Biomass and Potential Implications on Recalcitrance

ChemPhysChem, Volume 27, Issue 4, 25 February 2026.
Quantum mechanical calculations on 189 lignin‐hemicellulose models reveal that noncovalent interactions are modulated by methoxy substitution on lignin and carboxylate groups in monosaccharides. Increased methoxy substitution and carboxylation significantly strengthens their binding.
Eduardo Romero‐Montalvo, Samir H. Mushrif   +1 more
wiley   +1 more source

Preliminary study on MC1R polymorphism in some cattle breeds raised in Italy

Italian Journal of Animal Science, 2011
Most of the Western European cattle breeds consist of standardised breeds with a definite coat colour (Renieri et al., 1984). Thus coat colour could be useful to detect genetic markers for cattle breed identification.
C. Renieri, M. Cicogna, D. Meggiolaro, C. Gorni, M. Marilli, P. Crepaldi   +5 more
doaj   +1 more source