Results 271 to 280 of about 68,100 (329)

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

Revisiting the alpha-synuclein paradox in melanoma-Parkinson's disease connection: more than a tale of two cell fates. [PDF]

Cell Mol Life Sci
Aiello J, Zamarato R, Moscheni C, Perrotta C, Clerici M, Trabattoni D, Biasin M, Limanaqi F.   +7 more
europepmc   +1 more source

Reviewer #1 (Public Review): Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

Selene Seoyun Lee, Livia Civitelli, Laura Parkkinen   +2 more
openalex   +1 more source

The Need to Promote Olfactory Health in Public Health Agendas Across the Globe

Clinical Otolaryngology, EarlyView.
ABSTRACT Background A good sense of smell is essential for physical and mental health, and social wellbeing; however, across the globe, regardless of the setting, national public health agendas never consider smell health. This review aims to summarise the wide‐reaching impact of smell health in public health. Methods Narrative review of the literature
Carl Martin Philpott, Thomas Hummel, Valentina Parma, Matt Lechner, Duncan Boak, Marianna Obrist   +5 more
wiley   +1 more source

Retraction Note: Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts. [PDF]

BMC Complement Med Ther
Ardah MT, Ghanem SS, Abdulla SA, Lv G, Emara MM, Paleologou KE, Vaikath NN, Lu JH, Li M, Vekrellis K, Eliezer D, El-Agnaf OMA.   +11 more
europepmc   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, EarlyView.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Hidden faces of alpha-synuclein: Cryo-EM revelation of fibril polymorphs driven by disease, mutations, and PTMs. [PDF]

BBA Adv
Pirhaghi M, Mamashli F, Davaeil B, Mohammad-Zaheri M, Mousavi-Jarrahi Z, Tatzelt J, Saboury AA.   +6 more
europepmc   +1 more source

Protein tandem repeats that produce frameshifts can generate new structural states and functions

The FEBS Journal, EarlyView.
We explored an alternative protein structure landscape by analyzing amino acid sequences from frameshifted tandem repeats—regions prone to frameshifts. These frameshifts, especially in short repeats, lead to more drastic changes than in non‐repetitive regions, often altering structure, function, localization, and potentially contributing to disease ...
Zarifa Osmanli, Gudrun Aldrian, Jeremy Leclercq, Theo Falgarone, Santiago M. Gómez Bergna, Denis N. Prada Gori, Andrew V. Oleinikov, Ilham Shahmuradov, Andrey V. Kajava   +8 more
wiley   +1 more source

Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model. [PDF]

Aging (Albany NY)
Hoof V, Casadei N, Riess O, Schulze-Hentrich J, Hentrich T.   +4 more
europepmc   +1 more source