Results 281 to 290 of about 1,144,970 (369)

Physical and Mechanical Properties of Monomeric Alpha-Synuclein Provide Leads to Molecular Function. [PDF]

J Phys Chem B
Whitcomb KL, Warncke K.
europepmc   +1 more source

AZP2006 in Progressive Supranuclear Palsy: Outcomes from a Phase 2a Multicenter, Randomized Trial, and Open‐Label Extension on Safety, Biomarkers, and Disease Progression

Movement Disorders, EarlyView.
Abstract Objectives The aim was to evaluate the safety, tolerability, pharmacokinetics, and potential clinical efficacy of AZP2006, an oral pleiotropic drug modulating progranulin levels, in patients with progressive supranuclear palsy (PSP), a rare tauopathy. Methods A randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted at
Jean‐Christophe Corvol, Mickael Alexandre Obadia, Caroline Moreau, Louise‐Laure Mariani, Jean‐Philippe Brandel, David Devos, Sara Sambin, Nicolas Carrière, Günter Höglinger, Marie Lebouteux, Graziella Mangone, Noelle Callizot, Aurélien Blondel, Olivier Defert, Cecilia Estrella, Artin Karapet, Philippe Verwaerde, Luc Defebvre   +17 more
wiley   +1 more source

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease [PDF]

, 2012
Almas Siddiqui, Shankar J. Chinta, Jyothi K. Mallajosyula, Subramanian Rajagopolan, Ingrid M. Hanson, Anand Rane, Simon Melov, Julie K. Andersen   +7 more
openalex   +1 more source

A Biomarker‐Based Classification of Corticobasal Syndrome

Movement Disorders, EarlyView.
Abstract Background Corticobasal syndrome (CBS) is a clinically defined syndrome with progressive movement and cortical dysfunction, caused by various underlying pathologies, most commonly tau‐predominant pathologies such as progressive supranuclear palsy and corticobasal degeneration, or Alzheimer's disease (AD).
Carla Palleis, Alexander Maximilian Bernhardt, Endy Weidinger, Urban M. Fietzek, Alexander Jäck, Sabrina Katzdobler, Johannes Gnörich, Theresa Bauer, Nicolai Franzmeier, Robert Perneczky, German Imaging Initiative for Tauopathies (GII4T), Matthias Brendel, Johannes Levin, Günter U. Höglinger   +13 more
wiley   +1 more source

Stabilizing a Native Fold of Alpha-Synuclein with Short Helix-Constrained Peptides. [PDF]

JACS Au
Meade RM, Allen SG, Lopez AJ, Williams C, Thomas-Wright I, Heon-Roberts R, Carey-Wood M, Tang TMS, Sero JE, Hunt VL, Wade-Martins R, Crump MP, Mason JM.   +12 more
europepmc   +1 more source

Elucidating the Alpha-Synuclein Fibril Fold by Pulsed EPR [PDF]

, 2012
Maryam Hashemi Shabestari, Ine Segers‐Nolten, Mireille M. A. E. Claessens, Bart D. van Rooijen, Vinod Subramaniam, Martina Huber   +5 more
openalex   +1 more source

Digital Therapeutics for Alzheimer's and Parkinson's Diseases: Current Trends and Future Perspectives

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) and Parkinson's disease (PD), which are characterized by the accumulation of misfolded protein aggregates and cognitive/motor dysfunction, are the most prevalent neurodegenerative diseases (NDDs). Despite strategic investigations aimed at augmenting the pharmaceutical pipeline, available drugs for AD and PD merely slow
Yoo Joo Jeong, Hyun‐ju Lee, Jun‐Su Kim, Seung‐Jae Kim, Unhui Jo, Jin Yeop Park, Su Jin Jun, Won Seok Lee, Mingoo Song, Donggii Kim, Gyoujin Cho, Jeong‐Heon Song, Hyang‐Sook Hoe   +12 more
wiley   +1 more source

A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies. [PDF]

NPJ Parkinsons Dis
An S, McInnis JJ, Kim D, Li Y, Tasdemir-Yilmaz O, Ahn J, Mackness BC, Kwon SH, Bonner JM, Yoo M, Dujardin S, Kim D, Park J, Yun H, Tang Y, Pradier L, Hyeon S, Song D, Sung B, Krishnan R, Spencer B, Rissman RA, Sandhu JK, Haqqani AS, Shin JW, Kim DB, Lee H, Jung J, You WK, Star AT, Delaney CE, Stanimirovic DB, Sardi SP, Lee SH, Kayatekin C.   +34 more
europepmc   +1 more source

The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia [PDF]

, 2012
Shuwen Cao, David G. Standaert, Ashley S. Harms   +2 more
openalex   +1 more source

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, EarlyView.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source