Lipid peroxidation is essential for α-synuclein-induced cell death. [PDF]
, 2015 Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease.
Abramov, AY +5 more
core +2 more sources
rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration [PDF]
, 2013 Background Alpha-synuclein is a key protein implicated in the pathogenesis of Parkinson's disease (PD). It is the main component of the Lewy bodies, a cardinal neuropathological feature in the disease.
Anke Van der Perren +7 more
core +3 more sources
Examining a Link between Paraquat, Alpha-Synuclein Fibrillation and Neurodegeneration: A Review [PDF]
, 2014 Parkinson’s disease is a progressive and chronic disorder that causes motor system dysfunction due to a lack of dopamine in the central nervous system.
Ailaney, Nikhil
core +4 more sources
Synuclein expression in the lizard Anolis carolinensis [PDF]
, 2016 The synuclein (syn) family comprises three proteins: alpha-, beta- and gamma-syns. In humans, they are involved in neurodegenerative diseases such as Parkinson's disease and in tumors. Members of the syn family were sequenced in representative species of
BONACCORSI DI PATTI, Maria Carmela +3 more
core +1 more source
Photoaffinity labelling of alpha-synuclein using diazirine-functionalized caffeine, nicotine, and 1-aminoindan [PDF]
, 2020 Alpha-synuclein aggregation is a hallmark pathological feature of Parkinson’s disease, and as such, it is thought to be a contributing factor to the disease.
Moser, Brigitte Hope
core
Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. [PDF]
, 2014 BackgroundIn dementia with Lewy bodies (DLB) abnormal interactions between α-synuclein (α-syn) and beta amyloid (Aβ) result in selective degeneration of neurons in the neocortex, limbic system and striatum.
Cartier, Anna +9 more
core +3 more sources
Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease
Frontiers in Neuroscience, 2018 Alpha-synuclein (non A4 component of amyloid precursor, SNCA, NM_000345.3) plays a central role in the pathogenesis of Parkinson's disease (PD) and related Lewy body disorders such as Parkinson's disease dementia, Lewy body dementia, and multiple system ...
Desiree A. Piper +2 more
doaj +1 more source
Sleep dysfunction and EEG alterations in mice overexpressing alpha-synuclein. [PDF]
, 2014 BackgroundSleep disruptions occur early and frequently in Parkinson's disease (PD). PD patients also show a slowing of resting state activity. Alpha-synuclein is causally linked to PD and accumulates in sleep-related brain regions.
Chesselet, Marie-Françoise +3 more
core
Dynamic transport and localization of alpha-synuclein in primary hippocampal neurons. [PDF]
, 2010 BACKGROUND: Alpha-synuclein is a presynaptic protein with a proposed role in neurotransmission and dopamine homeostasis. Abnormal accumulation of alpha-synuclein aggregates in dopaminergic neurons of the substantia nigra is diagnostic of sporadic ...
George, JM +3 more
core +2 more sources
The G209A mutation in the alpha-synuclein gene in Brazilian families with Parkinson's disease [PDF]
, 2001 Hélio Afonso Ghizoni Teive +10 more
openalex +1 more source