Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. [PDF]
, 2015 BackgroundParkinson's disease (PD) is one of the most common causes of dementia and motor deficits in the elderly. PD is characterized by the abnormal accumulation of the synaptic protein alpha-synuclein (α-syn) and degeneration of dopaminergic neurons ...
Anderson, Scott +4 more
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Genetic Elements at the Alpha-Synuclein Locus
Frontiers in Neuroscience, 2022 Genome-wide association studies have consistently shown that the alpha-synuclein locus is significantly associated with Parkinson’s disease. The mechanism by which this locus modulates the disease pathology and etiology remains largely under-investigated.
Jordan Prahl, Gerhard A. Coetzee
openaire +3 more sources
αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease [PDF]
, 2017 The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role.
Alloatti, Matías +12 more
core +1 more source
Neurobiology of Disease, 2023 The role of alpha-synuclein in Parkinson's disease has been heavily investigated since its discovery as a component of Lewy bodies. Recent rodent data demonstrate that alpha-synuclein strain structure is critical for differential propagation and toxicity.
Audrey Fayard +15 more
doaj +1 more source
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Cell Death and Differentiation, 2020 Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death called ferroptosis.
Plamena R. Angelova +18 more
semanticscholar +1 more source
Behavioural deficits in transgenic mice expressing human truncated (1-120 amino acid) alpha-synuclein. [PDF]
, 2014 Accumulation and aggregation of alpha-synuclein in cortical and hippocampal areas is a pathological sign for dementia with Lewy bodies (DLB) and Parkinson's disease with dementia.
Anichtchik, Oleg +4 more
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Alpha-Synuclein to the Rescue: Immune Cell Recruitment by Alpha-Synuclein during Gastrointestinal Infection [PDF]
Journal of Innate Immunity, 2017 Intraneuronal accumulation of misfolded alpha-synuclein in the central and peripheral nervous systems is strongly linked to Parkinson disease (PD) and other related synucleinopathies. In rare inherited forms of PD, point mutations or gene multiplications mediate the formation of alpha-synuclein protein aggregates.
Viviane Labrie, Patrik Brundin
openaire +3 more sources
Parkinson's disease-related protein, alpha-synuclein, in malignant melanoma. [PDF]
PLoS ONE, 2010 Melanoma is the major cause of skin cancer death worldwide. Parkinson's disease is a neurodegenerative disorder that is caused by mutation of alpha-synuclein or other genes. Importantly, epidemiological studies have reported co-occurrence of melanoma and
Yasuhiro Matsuo, Tetsu Kamitani
doaj +1 more source
Colonic Alpha-Synuclein as Potential Early Biomarker for Parkinson's Disease Dementia [PDF]
Iranian Journal of Colorectal Research, 2022 Parkinson's Disease Dementia (PDD) is a cognitive and reasoning decline in many patients living with Parkinson's disease at least a year following diagnosis. PDD must be detected and treated promptly, as its advancement might impair the patient's quality
Elvan Wiyarta
doaj +1 more source
Alpha-Synuclein and Cognitive Decline in Parkinson Disease
Life, 2021 Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system.
Tian-Sin Fan, Sam Chi-Hao Liu, R. Wu
semanticscholar +1 more source