Results 91 to 100 of about 1,145,402 (246)

Prenatal diagnosis of thalassemia [PDF]

, 2008
published_or_final_versio
Chan, V, Cheong, KB, Leung, KY, Tang, MHY   +3 more
core  

Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

The prevalence of alpha-thalassemia amongst Tai and Mon-Khmer ethnic groups residing in northern Thailand: A population-based study

Hematology, 2016
Background: Northern Thailand is one of the highest α-thalassemia incidence areas where 30–40% of inhabitants have been reported to carry aberrant α-globin genes.
P. Lithanatudom, Pornnapa Khampan, Duncan R. Smith, S. Svasti, S. Fucharoen, D. Kangwanpong, Jatupol Kampuansai   +6 more
semanticscholar   +1 more source

ACMG/AMP‐Based Variant Classification of a Novel HBA2 Variant (HBA2: C.297del, Hb Taiping) in Compound Heterozygosity With Hb Adana (HBA2:C.179G>A) Causing Non‐Deletional Hb H Disease

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Accurate classification of novel globin gene variants is critical for the diagnosis and management of thalassaemia. The adaptation of ACMG/AMP guidelines for globin genes represents an important step toward standardising variant interpretation and enhancing clinical utility in the field.
Norafiza Mohd Yasin, Suguna Somasundram, Syahzuwan Hassan, Nur Aisyah Aziz, Faidatul Syazlin Abdul Hamid, Ezzanie Suffya Zulkefli, Nor Nazuha Mohamad, Chin Ming Lee, Mohd Nazif Darawi, Thessalia Papasavva, Coralea Stephanou, Petros Kountouris, Sandra J. G. Arkesteijn, Tamara Koopman, Cornelis L. Harteveld   +14 more
wiley   +1 more source

Association between Alpha- Klotho Protein, Calcium, and Phosphate concentrations in Adult Iraqi Patients with Beta-Thalassemia Major

مجلة كلية الطب
Background: Beta-thalassemia major is a prevalent global condition characterized by a rapid breakdown of red blood cells. Regular blood transfusions can give rise to problems such as cardiovascular disease, diabetes, osteoporosis, and renal disorders ...
Ahmed J. Kadhim, Hedef D. El-Yaseen, Ali M. Jawad   +2 more
doaj   +1 more source

Molecular bases of α-thalassemia in Argentina [PDF]

, 2015
La α-talasemia, es uno de los desórdenes hereditarios más frecuentes mundialmente. Al presente, el diagnóstico molecular es la única herramienta que permite el diagnóstico certero.
Cerrone, Gloria Edith, Copelli, Silvia Beatriz, Francipane, Liliana, Nash, Abigail, Scheps, Karen, Varela, Viviana   +5 more
core  

Accuracy of Malaria Rapid Diagnostic Tests in Community Studies and their Impact on Treatment of Malaria in an Area with Declining Malaria Burden in North-Eastern Tanzania. [PDF]

, 2011
Despite some problems related to accuracy and applicability of malaria rapid diagnostic tests (RDTs), they are currently the best option in areas with limited laboratory services for improving case management through parasitological diagnosis and ...
A Enevold, A Laurent, A Moody, AB Ly, BP Mmbando, BP Mmbando, Bruno P Mmbando, C Sayang, CA Petti, CI Chandler, CK Murray, CM Zikusooka, D Bell, D Bell, D Bell, Deus S Ishengoma, DJ Kyabayinze, DJ Kyabayinze, DR Ishengoma, DR Ishengoma, EK Ansah, Filbert Francis, H Hopkins, H Reyburn, H Reyburn, I Bates, Ib C Bygbjerg, J Bendezu, J Chinkhumba, John PA Lusingu, JP Lusingu, JP Lusingu, M Alifrangis, Martha M Lemnge, MI Msellem, Michael Alifrangis, Ministry of Health, ML McMorrow, ML McMorrow, MM Lemnge, N Singh, P Mens, Pamela Magistrado, R Development Core Team. R, RN Bronzan, S Gerstl, TA Abeku, Thor G Theander, V Batwala, V D'Acremont, WHO, WHO, WP O'Meara, Z Bisoffi, Z Bisoffi   +54 more
core   +4 more sources

Emergence of red blood cell alloantibodies and transfusion management in patients with warm autoantibodies at a tertiary care centre in British Columbia, Canada

Vox Sanguinis, EarlyView.
Abstract Background and Objectives The presence of warm autoantibodies (WAAs) complicates pre‐transfusion and compatibility testing. Despite attempts to provide antigen‐matched red blood cells (RBCs), the risk of alloimmunization remains. Rates of alloimmunization and indications for transfusion were reviewed to streamline testing and RBC provision ...
S. Hutspardol, J. Mi, C. Denesiuk, D. Kalar, L. Sham, M. Roche, J. R. Tsu, D. Lam, M. T. S. Yan   +8 more
wiley   +1 more source

Determination of the Need for Prenatal Diagnosis in Carriers of Alpha Thalassemia

مجله دانشکده پزشکی اصفهان, 2013
Background: In recent years, both alpha and beta thalassemia have been screened in couples before marriage. The severe form of alpha thalassemia, i.e. hydrops fetalis, is found in fetuses and causes fetal death.
Mitra Ramezani, Yadollah Ramezani, Davood Amirian, Mansoor Salehi   +3 more
doaj