Results 161 to 170 of about 5,544 (202)

Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

Biochemical Pharmacology, 2015
Javier Egea, Izaskun Buendia, Esther Parada   +2 more
exaly   +2 more sources

Alpha7 nicotinic‐N‐methyl‐D‐aspartate hypothesis in the treatment of schizophrenia and beyond

Human psychopharmacology, 2020
Development of novel treatments for positive, cognitive, and negative symptoms continue to be a high‐priority area of schizophrenia research and a major unmet clinical need. Given that all randomized controlled trials (RCTs) conducted to date failed with
M. Koola
semanticscholar   +1 more source

alpha7 receptor-selective agonists and modes of alpha7 receptor activation.

European journal of pharmacology, 2000
The alpha7-selective agonists 3-(2, 4-dimethoxybenzylidene)-anabaseine (GTS-21), also known as DMXB, and 3-(4-hydroxy,2-methoxybenzylidene)anabaseine (4OH-GTS-21) produce a variety of behavioral and cytoprotective effects that may be related to the activation of either large transient currents at high concentrations or small sustained currents at lower
R L, Papke, E, Meyer, T, Nutter, V V, Uteshev   +3 more
openaire   +2 more sources

First in Human Trial of a Type I Positive Allosteric Modulator of Alpha7-Nicotinic Receptors: Pharmacokinetics, Safety, and Evidence for Neurocognitive Effect of AVL-3288

Journal of Psychopharmacology, 2017
Type I positive allosteric modulators (PAMs) of the alpha7-nicotinic receptor enhance its cholinergic activation while preserving the spatiotemporal features of synaptic transmission and the receptor’s characteristic rapid desensitization kinetics ...
K. Gee, A. Olincy, R. Kanner, L. Johnson, D. Hogenkamp, Josette G. Harris, M. Tran, Stephen A Edmonds, R. Yoshimura, T. Johnstone, R. Freedman   +10 more
semanticscholar   +1 more source

Protective effect of alpha7 nAChR: Behavioural and morphological features on neuropathy

Pain, 2010
Traumatic, toxic or metabolic damage to the nervous system is the etiological foundation of neuropathic pain. Neuropathies are extremely difficult to treat and available drugs rarely joint an anti-hyperalgesic with a neurorestorative effect. From the literature, evidences support the alpha7 nicotinic receptor (nAChR) subtype as having a role in ...
PACINI, ALESSANDRA, DI CESARE MANNELLI, LORENZO, L. Bonaccini, S. Ronzoni, A. Bartolini, GHELARDINI, CARLA   +5 more
openaire   +3 more sources

Co-expression of the neuronal alpha7 and L247T alpha7 mutant subunits yields hybrid nicotinic receptors with properties of both wild-type alpha7 and alpha7 mutant homomeric receptors.

Proceedings of the National Academy of Sciences of the United States of America, 1997
Injection of cDNA encoding the neuronal alpha7 subunit into Xenopus oocytes yields homomeric receptors showing responses to AcCho that have low affinity, fast desensitization, nonlinear current-voltage (I-V) relation, and sensitivity to alpha-bungarotoxin (alpha-BTX) and 5-hydroxytryptamine (5HT), both substances acting as antagonists.
PALMA, Eleonora, EUSEBI, Fabrizio, MILEDI R.   +2 more
openaire   +2 more sources

Nicotinic Acetylcholine Receptors and the Roles of the Alpha7 Subunit

2014
Nicotinic acetylcholine receptors (nAChR) are members of the Cys-loop superfamily of ligand-gated ion channels that includes glycine, γ-aminobutyric acid (GABAA), and serotonin receptor channels. The members of the family are defined by a similar pentameric structure with five membrane-spanning subunits surrounding a central water-filled, cation ...
Michael Paolini, Mariella De Biasi, John A. Dani   +2 more
openaire   +1 more source

The antitussive effects of alpha7 (α7) nicotinic receptor agonists

Airway Pharmacology and Treatment, 2017
Background: Agonists for subtypes of the nicotinic class of acetylcholine receptors (nAChRs) have been evaluated for therapeutic effects in CNS disorders, pain and inflammation. A recent study in healthy nonsmokers described a marked antitussive effect of nicotine-containing vapors produced by e-Cigarettes (Chest 2016;149:161-5), a result consistent ...
Peter Dicpinigaitis, Brendan Canning, Robert DeVita, Michael Perelman, Qi Liu, Douglas Hay, Jing Liang   +6 more
openaire   +1 more source

Neuronal alpha-bungarotoxin receptors are alpha7 subunit homomers.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
Nicotinic acetylcholine receptors in the nervous system are heterogeneous with distinct pharmacological and functional properties resulting from differences in post-translational processing and subunit composition. Because of nicotinic receptor diversity, receptor purification and biochemical characterization have been difficult, and the precise ...
R C, Drisdel, W N, Green
openaire   +2 more sources

Virtual screening for alpha7 nicotinic acetylcholine receptor for treatment of Alzheimer's disease

Journal of Molecular Graphics and Modelling, 2013
Alzheimer's disease (AD) is the most common form of dementia. Although its cause and mechanism of progression are not well understood, various in vitro and in vivo experiments have proved that the decreased activity of the cholinergic neuron is responsible for the memory damage that is observed in these patients.
Shi-Gao, Chen, Ruo-Xu, Gu, Hao, Dai, Dong-Qing, Wei   +3 more
openaire   +2 more sources