Results 121 to 130 of about 7,901,793 (350)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Про механізм реакції окиснення ІЗО-Альфа-кислот хмелю киснем повітря [PDF]

, 2011
Розглянуто механізм процесу окиснення ізо-альфа-кислот (джерела гіркоти пива), які утворюються в процесі ізомеризації альфа-кислот при кип'ятінні сусла із хмелем. Встановлено, що за рахунок реакцій окиснення ізо-альфа-кислот відбувається утворення в пиві
Березка, Т. О., Гладкий, Федір Федорович, Данилова, Людмила Андріївна, Домарецький, В. А., Півень, Олена Миколаївна   +4 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Simulation of organismic morphology and behavior by synthetic poly-alpha-amino acids [PDF]

Simulation of organismic morphology and behavior by synthetic poly-amino ...
Fox, S. W., Joseph, D., Mc Cauley, R., Windsor, C. R. W., Yuyama, S.   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

BIOCHEMICAL CRITERIA OF BREWING EVALUATION OF AROMATIC HOP VARIETIES

Harčova Nauka ì Tehnologìâ
With the expansion of the assortment of beer, brewers increasingly use different hop products of new varieties of hop, that makes it possible to obtain beer with certain profiles of taste and aroma.
L. Protsenko, N. Koshitska, S. Ryzhuk, O. Svirchevska, А. Bober, S. Gunko, L. Janse   +6 more
doaj   +1 more source

The Absolute Configuration of alpha,alpha'-Diethylsuccinic Acid and alpha-Methyl-alpha'-ethylsuccinic Acid. [PDF]

Acta Chemica Scandinavica, 1964
Arne Fredga, Lars Terenius, Tore Ledaal, Hans M. Seip   +3 more
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

One Pot Synthesis of Alpha-Aminonitrile and Alpha-Amino Acid From Schiff Bases [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1999
Addition of Potassium cyanide to a mixture of Schiff base and lithium perchlorate afforded a-aminonitriles in high yields. Addition of potassium cyanide to a methanolic solution of Schiff base and phosphoric acid afforded a-aminonitriles.
Mohammad M. Hashemi, Behnaz Almasi
doaj