Results 71 to 80 of about 570,864 (312)

The thermal structural transition of alpha-crystallin modulates subunit interactions and increases protein solubility. [PDF]

PLoS ONE, 2012
BACKGROUND: Alpha crystallin is an oligomer composed of two types of subunits, alpha-A and alpha-B crystallin, and is the major constituent of human lens. The temperature induced condensation of alpha-crystallin, the main cause for eye lens opacification
Giuseppe Maulucci, Marco De Spirito, Giuseppe Arcovito, Massimiliano Papi   +3 more
doaj   +1 more source

Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes [PDF]

, 1986
Several cDNA clones coding for the high molecular weight (alpha) subunit of the voltage-sensitive Na channel have been selected by immunoscreening a rat brain cDNA library constructed in the expression vector lambda gt11.
Auld, Vanessa, Catterall, William A., Davidson, Norman, Downey, William, Dowsett, Andrew, Dunn, Robert, Fritz, Larry C., Goldin, Alan L., Lester, Henry A., Lübbert, Hermann, Marshall, John, Snutch, Terry P.   +11 more
core  

Variants of human chorionic gonadotropin from pregnant women and tumor patients recognized by monoclonal antibodies [PDF]

, 1993
In biological fluids, hCG and its free alpha- (hCG alpha) and beta-subunits (hCG beta), occur in multiple forms. These various forms differ at the molecular level primarily in glycosylation, but also differ in protein backbone modifications corresponding
Berger, Peter, Mann, Klaus, Schwarz, Siegfried, Spöttl, Gerald, Wick, Georg   +4 more
core   +1 more source

Immunoaffinity purification of GABAA receptor alpha-subunit iso-oligomers. Demonstration of receptor populations containing alpha 1 alpha 2, alpha 1 alpha 3, and alpha 2 alpha 3 subunit pairs.

Journal of Biological Chemistry, 1991
Novel methods for the isolation of gamma-aminobutyric acidA (GABAA) receptor alpha subunit iso-oligomers have been developed. Thus, populations of GABAA receptors containing the GABAA receptor alpha 1 subunit, the alpha 2 subunit, and the alpha 3 subunit have been purified from sodium deoxycholate extracts of bovine cerebral cortex with the retention ...
M J, Duggan, S, Pollard, F A, Stephenson
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.

PLoS Genetics, 2010
Although acetylated alpha-tubulin is known to be a marker of stable microtubules in neurons, precise factors that regulate alpha-tubulin acetylation are, to date, largely unknown.
Jachen A Solinger, Roberta Paolinelli, Holger Klöss, Francesco Berlanda Scorza, Stefano Marchesi, Ursula Sauder, Dai Mitsushima, Fabrizio Capuani, Stephen R Stürzenbaum, Giuseppe Cassata   +9 more
doaj   +1 more source

A schistosome [beta] subunit remodels inactivation of a calcium channel _via_ an N-terminal polyacidic motif [PDF]

, 2010
The beta subunit of high voltage-activated Ca (Cav) channels targets the pore forming [alpha]~1~ subunit to the plasma membrane and defines the biophysical phenotype of the Cav channel complex. Cav channel inactivation following activation and opening is
Robert M. Greenberg, Vicenta Salvador-Recatala   +1 more
core   +1 more source

Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans. [PDF]

, 2017
In Caenorhabditis elegans, the AWC neurons are thought to deploy a cGMP signaling cascade in the detection of and response to AWC sensed odors. Prolonged exposure to an AWC sensed odor in the absence of food leads to reversible decreases in the animal's ...
BT Juang, C Peng, CI Bargmann, CM Coburn, CM Coburn, DM O’Halloran, DM O’Halloran, ER Troemel, F Paquet-Durand, H Komatsu, H Komatsu, H Zhong, H Zhong, HA Colbert, HA Colbert, HK Smith, J Bradley, J Zheng, J Zheng, JA Kaye, JF Etchberger, JI Lee, JL Krajewski, KR Kelliher, M Wojtyniak, MC Trudeau, N Blom, ND L’Etoile, O Hobert, PD Wes, PM Jenkins, S Brenner, S Kohl, S Michalakis, SW Cho, SW Cho, TK Kerppola, TY Chen, Y Song, YJ Shyu   +39 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity.

PLoS ONE, 2008
BackgroundThe Ca(v)beta subunits of high voltage-activated Ca(2+) channels control the trafficking and biophysical properties of the alpha(1) subunit. The Ca(v)beta-alpha(1) interaction site has been mapped by crystallographic studies.
Iuliia Vitko, Aleksandr Shcheglovitov, Joel P Baumgart, Imilla I Arias-Olguín, Janet Murbartián, Juan Manuel Arias, Edward Perez-Reyes   +6 more
doaj   +1 more source