Results 201 to 210 of about 67,783 (305)

Simultaneous Assessment of Intracranial Artery and Paravascular CSF Pulsation Using 3D Whole‐Brain Diffusion‐Prepared Cine bSSFP (DECAF) MRI

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To propose a noninvasive and quantitative MRI approach to simultaneously assessing intracranial artery pulsation and paravascular cerebrospinal fluid (CSF) pulsation in the human brain. Methods We developed a 3D whole‐brain Diffusion‐prepared Cine bSSFP (DECAF) MRI technique, with improved motion‐sensitized driven‐equilibrium providing
Chang Ni   +8 more
wiley   +1 more source

Exercise, exerkines, and muscle–brain crosstalk in Parkinson's disease

open access: yesNeuroprotection, EarlyView.
Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non‐motor symptoms, driven by dopaminergic loss and α‐synuclein accumulation. Beyond neurodegeneration, growing evidence highlights skeletal muscle health as a key determinant of prognosis, with sarcopenia and frailty contributing to greater disability, fall ...
Salomón Páez‐García   +7 more
wiley   +1 more source

Dermal Alpha-Synuclein Aggregation in Seed Amplification Assays for Parkinson's Disease Subtype Differentiation. [PDF]

open access: yesEur J Neurol
Vieregge M   +6 more
europepmc   +1 more source

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo   +3 more
wiley   +1 more source

SERS‐Based Nano‐ and Microsystems Toward Biomedical Applications

open access: yesSmall, EarlyView.
This review provides a current overview of nano‐ and microscale SERS‐based devices, encompassing all aspects from material design to practical applications. We highlight controlled SERS‐active architectures, including patterned substrates, nanorods, microspheres, micromotors, and microneedles, as well as combinations of these microfluidic systems.
Gohar Soufi   +14 more
wiley   +1 more source

Formation of Condition-Dependent Alpha-Synuclein Fibril Strain in Artificial Cerebrospinal Fluid. [PDF]

open access: yesAdv Sci (Weinh)
Sniečkutė R   +7 more
europepmc   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

open access: yesVIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang   +6 more
wiley   +1 more source

Rethinking Mitochondrial Parkinson's Disease in the α‐Synuclein Seed Amplification Assays Era

open access: yes
Movement Disorders, EarlyView.
Marco Percetti   +3 more
wiley   +1 more source

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