Results 61 to 70 of about 67,783 (305)

Association between Serum Alpha-Synuclein Levels and Parkinson's Disease Stage

Global Medical & Health Communication, 2022
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's. It is chronically progressive with the main symptoms of resting tremor, rigidity, bradykinesia, and postural disturbances.
Yuliarni Syafrita, Restu Susanti
doaj   +1 more source

The potential role of dietary polyphenols in Parkinson’s disease [PDF]

, 2011
Cumulative evidence now suggests that the abnormal aggregation of the neuronal protein alpha-synuclein is critically involved in the pathogenesis of synucleinopathies, of which Parkinson’s disease (PD) is the most prevalent. Development of neuropathology
Caruana, Mario, Vassallo, Neville
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Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

Rational design of structure‐based vaccines targeting misfolded alpha‐synuclein conformers of Parkinson's disease and related disorders

Bioengineering & Translational Medicine
Synucleinopathies, including Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are neurodegenerative disorders caused by the accumulation of misfolded alpha‐synuclein protein.
Jose Miguel Flores‐Fernandez, Verena Pesch, Aishwarya Sriraman, Enrique Chimal‐Juarez, Sara Amidian, Xiongyao Wang, Caleb Duckering, Andrew Fang, Sara Reithofer, Liang Ma, Leonardo M. Cortez, Valerie L. Sim, Gültekin Tamgüney, Holger Wille   +13 more
doaj   +1 more source

Phosphorylation does not prompt, nor prevent, the formation of α-synuclein toxic species in a rat model of Parkinson's disease [PDF]

, 2017
Phosphorylation is involved in numerous neurodegenerative diseases. In particular, alpha-synuclein is extensively phosphorylated in aggregates in patients suffering from synucleinopathies.
Abbas-Terki, Toufik, Aebischer, Patrick, Azeredo da Silveira, Samareh, Cifuentes-Diaz, Carmen, Iwatsubo, Takeshi, Sage, Daniel, Schneider, Bernard L., Unser, Michaël   +7 more
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Direct detection of alpha synuclein oligomers in vivo [PDF]

, 2014
Background: Rat models of Parkinson’s disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches.
Dimant, Hemi, Ebrahimi-Fakhari, Darius, Fan, Zhanyun, Hyman, Bradley T, Kalia, Lorraine V, Kalia, Suneil K, Kibuuka, Laura, McFarland, Nikolaus R, McLean, Pamela J, Zhu, Liya N   +9 more
core   +1 more source

Probiotic Bacillus subtilis protects against α-synuclein aggregation in C. elegans [PDF]

, 2020
How the gut microbiome affects Parkinson's disease remains unclear. Goya et al. show that the probiotic B. subtilis strain PXN21 inhibits and clears α-synuclein aggregation in a C. elegans model.
Arnaouteli, Sofia, Ball, Kathryn, Brydon, Jack, Doitsido, Maria, Goya, María Eugenia, Riquelme-Dominguez, Lourdes, Romanowski, Andrés, Sampedro-Torres-Quevedo, Cristina, Stanley-Wall, Nicola, Xue, Feng   +9 more
core   +5 more sources

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

The relationship of alpha-synuclein to mitochondrial dynamics and quality control

Frontiers in Molecular Neuroscience, 2022
Maintenance of mitochondrial health is essential for neuronal survival and relies upon dynamic changes in the mitochondrial network and effective mitochondrial quality control mechanisms including the mitochondrial-derived vesicle pathway and mitophagy ...
Naomi J. Thorne, David A. Tumbarello
doaj   +1 more source

The synucleins. [PDF]

, 2002
PMC ID: PMC150459. The author can archive publisher's version/PDF.SUMMARY: Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors.
George, JM
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