Results 141 to 150 of about 38,874 (189)
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Alpha-Thalassemia in Ashkenazi Jews
Annals of Internal Medicine, 1983Members of a Jewish family of Polish origin were found to have hypochromic, microcytic erythrocytes. By restriction endonuclease analysis of DNA, the propositus, a brother, and an aunt were found to have a single alpha-globin gene on each chromosome 16. Five family members have one chromosome bearing two alpha-genes (5' and 3') with a single alpha-gene
G B, Sancar +6 more
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Hydrops Fetalis with Alpha Thalassemia
New England Journal of Medicine, 1967HYDROPS fetalis associated with hemoglobin Barts is believed to represent the homozygous state of α thalassemia. Ten cases occurring in Chinese families in Indonesia, Malaya and Hong Kong, 1 in a Greek Cypriot family and 1 in a Filipino family, have been described.1 2 3 4 5 6 7 Recently, several more cases have been seen among Chinese in Hong Kong.8 We
Y W, Kan, A, Allen, L, Lowenstein
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Annales de biologie clinique, 1995
alpha-Thalassaemias are probably the most common genetic disorder worldwide. alpha-Thalassaemias are haemolytic anaemias resulting from inherited deficient synthesis of alpha-globin chains. In this paper, the classification and nomenclature of alpha-thalassaemias are developed. Procedures to ensure the laboratory diagnosis are explained.
J Y, Peltier, C, Sayada, R, Girot
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alpha-Thalassaemias are probably the most common genetic disorder worldwide. alpha-Thalassaemias are haemolytic anaemias resulting from inherited deficient synthesis of alpha-globin chains. In this paper, the classification and nomenclature of alpha-thalassaemias are developed. Procedures to ensure the laboratory diagnosis are explained.
J Y, Peltier, C, Sayada, R, Girot
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The Clinical Phenotypes of Alpha Thalassemia
Hematology/Oncology Clinics of North America, 2023Clinical manifestations of α-thalassemia range from no symptoms to severe transfusion-dependent anemia. Alpha thalassemia trait is deletion of 1 to 2 α-globin genes, whereas α-thalassemia major (ATM; Barts hydrops fetalis) is the deletion all 4 α genes.
Ashutosh, Lal, Elliott, Vichinsky
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[Alpha thalassemia in Macedonia].
Bilten za hematologiju i transfuziju, 1983The frequency of alpha thalassemia in SR Macedonia was determined with studies of Hb Bart's in 1.140 newborn babies. Hb Bart's was found in 83 infants. Distribution of the levels of Hb Bart's in these neonates, as determined by column chromatography on CM Sephadex, was trimodal. The mean values for Hb Bart's in the three groups were 0.5% (SD = 0.22), 1.
G, Efremov +3 more
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Molecular genetics of alpha thalassemia
Medical Hypotheses, 1989Linked duplicate genes in Chromosome 16 condition the production not only of alpha-globin chains in the Hemoglobin A (HbA) molecule, but also of the varied forms of alpha thalassemia in human subjects. Null allelism, not gene deletion, exists at these gene loci.
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Beta-thalassemia associated with alpha-thalassemia in Thailand.
Hemoglobin, 1989In Thailand alpha-thalassemia (thal), beta-thal, hemoglobin (Hb) E and Hb Constant Spring (Hb CS) are prevalent. The incidences are 20-30% for alpha-thal (3.5% for alpha-thal-1 and 16% for alpha-thal-2), 3-9% for beta-thal, up to 54% for Hb E and nearly 8% for Hb CS.
S, Fucharoen +2 more
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Alpha thalassemia allelic frequency in Lebanon
Pediatric Blood & Cancer, 2014BackgroundHemoglobinopathies are the most common reported monogenic disorders worldwide. It is well established that Mediterranean and Arab countries are high risk areas for thalassemia in general, and for alpha thalassemia in particular. Reports of alpha thalassemia gene mutations from the Lebanese population are limited.ProcedureWe investigated the ...
Chantal, Farra +8 more
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Alpha-thalassemia in Papua New Guinea
Human Genetics, 1986A study of the distribution of alpha-thalassemia in Papua New Guinea (PNG) was carried out by DNA analysis. A total of 664 DNA samples were screened for alpha-thalassemia 2 and alpha-thalassemia 1 caused respectively by either deletion of one or both of the duplicated alpha-globin genes.
Yenchitsomanus, P. +6 more
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Erythropoietin Levels in Heterozygous Alpha-Thalassemia
Acta Haematologica, 1986In guinea pig bone marrow cultures with heterozygous alpha-thalassemic serum, 59Fe uptake values are elevated above iron values of cultures with serum of normal subjects. These results show that erythropoietin (EP) activity values in heterozygous alpha-thalassemia are comparable to those previously observed by ourselves in heterozygous beta-thalassemia
M, Vedovato +5 more
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