Results 161 to 170 of about 1,319,935 (211)
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American Journal of Hematology, 1977
AbstractThe current concepts of α‐thalassemia including incidence, genetics, clinical spectrum and diagnosis are reviewed. Speculation concerning clinical application of the molecular biology of α‐thalassemia is also presented.
J G, Adams, M H, Steinberg
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AbstractThe current concepts of α‐thalassemia including incidence, genetics, clinical spectrum and diagnosis are reviewed. Speculation concerning clinical application of the molecular biology of α‐thalassemia is also presented.
J G, Adams, M H, Steinberg
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Alpha-Thalassemia in Ashkenazi Jews
Annals of Internal Medicine, 1983Members of a Jewish family of Polish origin were found to have hypochromic, microcytic erythrocytes. By restriction endonuclease analysis of DNA, the propositus, a brother, and an aunt were found to have a single alpha-globin gene on each chromosome 16. Five family members have one chromosome bearing two alpha-genes (5' and 3') with a single alpha-gene
G B, Sancar +6 more
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Distribution of alpha-thalassemia mutations in Iranian population
Hematology, 2015 Mohamad Moghadam +2 more
exaly +2 more sources
Alpha-Thalassemia Carrier due to –α3.7 Deletion: Not So Silent
Acta Haematologica, 2020Background/Objective: Alpha-thalassemia is one of the most prevalent genetic diseases, with the –α3.7 deletion being the most common mutation. Molecular studies have suggested mechanisms to explain the mild phenotype of “silent carrier” heterozygotes ...
O. Gilad +6 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2017 Most α-thalassemia cases are caused by deletions of the structural α-globin genes. The degree of microcytosis and hypochromia has been correlated with the number of affected α-globin genes, suggesting a promising role of hematologic parameters as ...
Diego Velasco-Rodriguez +2 more
exaly +2 more sources
Blood Cells, Molecules, and Diseases, 2019
INTRODUCTION Identification of beta-thalassemia carrier in prenatal screening relies on the elevated Hb A2 level. Borderline Hb A2 levels pose a diagnostic challenge.
Kanda Fanhchaksai +2 more
exaly +2 more sources
INTRODUCTION Identification of beta-thalassemia carrier in prenatal screening relies on the elevated Hb A2 level. Borderline Hb A2 levels pose a diagnostic challenge.
Kanda Fanhchaksai +2 more
exaly +2 more sources
Hydrops Fetalis with Alpha Thalassemia
New England Journal of Medicine, 1967HYDROPS fetalis associated with hemoglobin Barts is believed to represent the homozygous state of α thalassemia. Ten cases occurring in Chinese families in Indonesia, Malaya and Hong Kong, 1 in a Greek Cypriot family and 1 in a Filipino family, have been described.1 2 3 4 5 6 7 Recently, several more cases have been seen among Chinese in Hong Kong.8 We
Y W, Kan, A, Allen, L, Lowenstein
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Alpha thalassemia allelic frequency in Lebanon
Pediatric Blood and Cancer, 2015Chantal Farra +2 more
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Annales de biologie clinique, 1995
alpha-Thalassaemias are probably the most common genetic disorder worldwide. alpha-Thalassaemias are haemolytic anaemias resulting from inherited deficient synthesis of alpha-globin chains. In this paper, the classification and nomenclature of alpha-thalassaemias are developed. Procedures to ensure the laboratory diagnosis are explained.
J Y, Peltier, C, Sayada, R, Girot
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alpha-Thalassaemias are probably the most common genetic disorder worldwide. alpha-Thalassaemias are haemolytic anaemias resulting from inherited deficient synthesis of alpha-globin chains. In this paper, the classification and nomenclature of alpha-thalassaemias are developed. Procedures to ensure the laboratory diagnosis are explained.
J Y, Peltier, C, Sayada, R, Girot
openaire +1 more source