Results 171 to 180 of about 1,319,935 (211)

Molecular genetics of alpha thalassemia

Medical Hypotheses, 1989
Linked duplicate genes in Chromosome 16 condition the production not only of alpha-globin chains in the Hemoglobin A (HbA) molecule, but also of the varied forms of alpha thalassemia in human subjects. Null allelism, not gene deletion, exists at these gene loci.
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Beta-thalassemia associated with alpha-thalassemia in Thailand.

Hemoglobin, 1989
In Thailand alpha-thalassemia (thal), beta-thal, hemoglobin (Hb) E and Hb Constant Spring (Hb CS) are prevalent. The incidences are 20-30% for alpha-thal (3.5% for alpha-thal-1 and 16% for alpha-thal-2), 3-9% for beta-thal, up to 54% for Hb E and nearly 8% for Hb CS.
S, Fucharoen, P, Winichagoon, V, Thonglairuam   +2 more
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Advances in the treatment of alpha-thalassemia

Blood Reviews, 2012
Alpha (α)-thalassemia represents a group of recessively inherited hemoglobin disorders marked by deficient or absent synthesis of 1 to all 4 of the α-globin genes. Inactivation of 3 α-globin genes--either by deletional or nondeletional mutations--results in hemoglobin H (Hb H) disease.
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[Alpha thalassemia in Macedonia].

Bilten za hematologiju i transfuziju, 1983
The frequency of alpha thalassemia in SR Macedonia was determined with studies of Hb Bart's in 1.140 newborn babies. Hb Bart's was found in 83 infants. Distribution of the levels of Hb Bart's in these neonates, as determined by column chromatography on CM Sephadex, was trimodal. The mean values for Hb Bart's in the three groups were 0.5% (SD = 0.22), 1.
G, Efremov, N, Stojanovski, B, Nastev, C, Zisovska   +3 more
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THE MOLECULAR AND HEMATOLOGICAL HETEROGENEITY OF ALPHA THALASSEMIA

Australian and New Zealand Journal of Medicine, 1984
Abstract:A study of genotypes in ? thalassemia and their corresponding hematological phenotypes has shown that α+ thalassemia is the most frequent type encountered in a Sydney population. Phenotypes of heterozygous α+ thalassemia (αα/−α) in adults or children differ little from normal and so the disorder is difficult to identify. In contrast, Hb Bart's
R J, Trent, J, Yakas, P E, Brock, H, Kronenberg   +3 more
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Alpha thalassemia, but not βS-globin haplotypes, influence sickle cell anemia clinical outcome in a large, single-center Brazilian cohort

Annals of Hematology, 2021
B. L. Hatzlhofer, D. Pereira-Martins, Igor de Farias Domingos, G. S. Arcanjo, I. Weinhäuser, D. A. Falcão, Isabela Cristina Cordeiro Farias, Jéssica Vitória Gadelha de Freitas Batista, L. Prado, Jéssica M F Oliveira, Thais H C Batista, Marcondes J. Sobreira, Rodrigo Marcionilo de Santana, A. S. Araújo, Manuela A de Melo, Bruna Vasconcelos de Ancântara, J. Coelho-Silva, Ana Beatriz Lucas de Moura Rafael, Danízia Menezes de Lima Silva, Flávia P Albuquerque, M. N. Santos, A. C. D. dos Anjos, F. Costa, Aderson da Silva Araujo, A. Lucena-Araújo, M. Bezerra   +25 more
semanticscholar   +1 more source

Alpha-Thalassemia as Cause of Nonimmunological Hydrops

Archives of Pediatrics & Adolescent Medicine, 1965
IN 1955 A Filipino couple had a premature fetus with clinical and pathological features of hydrops fetalis, but no iso-immune basis for the disease could be documented. The 1962 report of Lie-Injo and her associates in Indonesia describing homozygous α-thalassemia as a cause of nonimmunological hydrops fetalis1prompted reinvestigation of this family ...
H A, PEARSON, D R, SHANKLIN, C R, BRODINE   +2 more
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Erythropoietin Levels in Heterozygous Alpha-Thalassemia

Acta Haematologica, 2009
In guinea pig bone marrow cultures with heterozygous α-thalassemic serum, 59Fe uptake values are elevated above iron values of cultures with serum of normal subjects. These results show that erythropoietin (EP) activity values in heterozygous α-thalassemia are comparable to those previously observed by ourselves in heterozygous β-thalassemia despite of
M, Vedovato, G, Salvatorelli, G C, Balboni, M, Taddei Masieri, B, Dolcini, C, Toffoli   +5 more
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alpha-Thalassemia and beta-thalassemia in a Turkish family.

American journal of hematology, 1977
A Turkish family is described in which three children have a clinical picture similar to that of thalassemia major, with typical red cell morphology and indices, and with about 10% Hb Bart's but without measurable amounts of Hb H. Hematological evaluation of six members of this family that included in vitro hemoglobin synthesis suggests that beta-(or ...
C, Altay, B, Say, S, Yetgin, T H, Huisman   +3 more
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Alpha-thalassemia in Thailand.

Hemoglobin, 1989
The alpha-thalassemia syndromes are remarkable both for their phenotypic diversity and for their different clinical severity. They are associated with variable degrees of alpha-chain deficits; the clinical manifestations range from asymptomatic cases with normal hematologic findings to the totally lethal Hb Bart's hydrops fetalis syndrome.
P, Winichagoon, V, Thonglairuam, S, Fucharoen, V S, Tanphaichito, P, Wasi   +4 more
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