Results 31 to 40 of about 39,321 (195)
The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells. [PDF]
, 2015 Lentiviral vectors designed for the treatment of the hemoglobinopathies require the inclusion of regulatory and strong enhancer elements to achieve sufficient expression of the β-globin transgene.
Baldwin, Kismet M +12 more
core +4 more sources
Anemia, 2015 Background. Nontransfusion dependent thalassemia (NTDT) is a milder form of thalassemia that does not require regular transfusion. It is associated with many complications, which differ from that found in transfusion-dependent thalassemia (TDT ...
Poramed Winichakoon +7 more
doaj +1 more source
Revista Brasileira de Hematologia e Hemoterapia, 2015 BACKGROUND: In sickle cell disease, the quantification of Hb A2 is important for the differential diagnosis between sickle cell anemia (Hb SS) and Hb S/ß0-thalassemia.OBJECTIVE: To determine Hb A2 levels as quantified by high performance liquid ...
Silvana Fahel da Fonseca +4 more
doaj +1 more source
Awareness of the Thalassemic Patients’ Parents toward Thalassemia in Kirkuk City [PDF]
مجلة الموصل للتمريض, 2014 Background and objectives:- Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form of hemoglobin, the protein in red blood cells that carries oxygen.
Yousif Abdulmuhsin Salih
doaj +1 more source
Thalassemia, a human blood disorder
Brazilian Journal of Biology, 2021 A group of inherited blood defects is known as Thalassemia is among the world’s most prevalent hemoglobinopathies. Thalassemias are of two types such as Alpha and Beta Thalassemia. The cause of these defects is gene mutations leading to low levels and/or
F. Shafique +8 more
doaj +1 more source
Mediterranean Journal of Hematology and Infectious Diseases, 2023 Background and objectives. Investigating the prevalence of thalassemia in the Vietnamese population, building a clinical decision support system for prenatal screening for thalassemia. Methods.
Danh Cuong Tran +7 more
doaj +1 more source
Update in Laboratory Diagnosis of Thalassemia
Frontiers in Molecular Biosciences, 2020 Alpha- and β-thalassemias and abnormal hemoglobin (Hb) are common in tropical countries. These abnormal globin genes in different combinations lead to many thalassemic diseases including three severe thalassemia diseases, i.e., homozygous β-thalassemia ...
Thongperm Munkongdee +4 more
doaj +1 more source
Thalassemia intermedia as a result of heterozygosis for ß0-thalassemia and aaaanti-3.7/aa genotype in a Brazilian patient [PDF]
Brazilian Journal of Medical and Biological Research, 2003 We report a case in which the interaction of heterozygosis for both the ß0-IVS-II-1 (G->A) mutation and the aaaanti-3.7 allele was the probable cause for the clinical occurrence of thalassemia intermedia.
E.M. Kimura +4 more
doaj +1 more source
The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]
, 2020 Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
core +1 more source
Alpha Thalassemia in Istanbul: Distribution of Deletions in Alpha-globin Gene Cluster
Genel Tıp DergisiBackground/Aims: Alpha thalassemia is an autosomal recessive congenital disease resulting from a globin protein disorder encoded by genes in the alpha thalassemia gene cluster.
Fatma Nihal Öztürk
doaj +1 more source