Results 111 to 120 of about 27,933 (291)
Mutagenesis of the conserved 51-nucleotide region of Sindbis virus [PDF]
We have constructed 25 site-specific mutations in a domain of 51 nucleotides in Sindbis virus that is highly conserved among all alphaviruses sequenced to date.
Niesters, Hubert G. M. +1 more
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A Viral mRNA Motif at the 3′-Untranslated Region that Confers Translatability in a Cell-Specific Manner. Implications for Virus Evolution [PDF]
Sindbis virus (SINV) mRNAs contain several motifs that participate in the regulation of their translation. We have discovered a motif at the 3′ untranslated region (UTR) of viral mRNAs, constituted by three repeated sequences, which is involved in the ...
Carrasco, Luis +2 more
core +2 more sources
Diversity in viral anti-PKR mechanisms: A remarkable case of evolutionary convergence [PDF]
Most viruses express during infection products that prevent or neutralize the effect of the host dsRNA activated protein kinase (PKR). Translation of Sindbis virus (SINV) mRNA escapes to PKR activation and eIF2 phosphorylation in infected cells by a ...
Domingo-Gil, Elena +4 more
core +1 more source
Neuroinvasive infections with mosquito-borne alphaviruses such as Western equine encephalitis virus (WEEV) can cause post-encephalitic parkinsonism. To understand the mechanisms underlying these neurological effects, we examined the capacity of WEEV to ...
C. Bantle +5 more
semanticscholar +1 more source
Salmonid alphavirus infection results in pancreas disease causing severe economic losses for Atlantic salmon aquaculture. Knowledge about genes and pathways contributing to resistance is limited.
M. L. Aslam +8 more
semanticscholar +1 more source
Understanding the virus‐host arms race has been a fascinating topic in virology; contributing significantly to the development of treatments and control strategies for viral diseases. CHV1 employs a sophisticated counter‐defense mechanism in its fungal host by utilizing a viral silencing suppressor to inhibit fungal FMN reductase; thereby modulating ...
Shiyu Zhai +8 more
wiley +1 more source
An alternative pathway for alphavirus entry [PDF]
Abstract The study of alphavirus entry has been complicated by an inability to clearly identify a receptor and by experiments which only tangentially and indirectly examine the process, producing results that are difficult to interpret. The mechanism of entry has been widely accepted to be by endocytosis followed by acidification of the ...
Brown Dennis T +2 more
openaire +3 more sources
Use of a lambda gt11 expression library to localize a neutralizing antibody-binding site in glycoprotein E2 of Sindbis virus [PDF]
The Sindbis virus envelope contains two species of integral membrane glycoproteins, E1 and E2. These proteins form heterodimers, and three dimeric units assemble to form spikes incorporated into the viral surface which play an important role in the ...
Strauss, James H., Wang, Kang-Sheng
core +1 more source
An All‐in‐One Metabarcoding Approach to Mosquito and Arbovirus Xenosurveillance
ABSTRACT Next‐generation sequencing (NGS) has the potential to transform mosquito‐borne disease surveillance but remains under‐utilised. This study introduces a comprehensive multi‐loci metabarcoding‐based MX (molecular xenomonitoring) approach to mosquito and arbovirus surveillance, enabling parallel identification of mosquito vectors, circulating ...
Brian J. Johnson +12 more
wiley +1 more source
Semliki Forest viiruse replikaasivalgu nsP1 uurimine [PDF]
Väitekirja elektrooniline versioon ei sisalda publikatsioone.Semliki Forest viirus kuulub alfaviiruste perekonda sugukonnas Togaviridae. Alfaviirused on olulised patogeenid ning põhjustavad erinevaid vaevusi nii loomadele kui ka inimestele.
Karo-Astover, Liis
core

