Results 111 to 120 of about 27,933 (291)

Mutagenesis of the conserved 51-nucleotide region of Sindbis virus [PDF]

open access: yes, 1990
We have constructed 25 site-specific mutations in a domain of 51 nucleotides in Sindbis virus that is highly conserved among all alphaviruses sequenced to date.
Niesters, Hubert G. M.   +1 more
core  

A Viral mRNA Motif at the 3′-Untranslated Region that Confers Translatability in a Cell-Specific Manner. Implications for Virus Evolution [PDF]

open access: yes, 2016
Sindbis virus (SINV) mRNAs contain several motifs that participate in the regulation of their translation. We have discovered a motif at the 3′ untranslated region (UTR) of viral mRNAs, constituted by three repeated sequences, which is involved in the ...
Carrasco, Luis   +2 more
core   +2 more sources

Diversity in viral anti-PKR mechanisms: A remarkable case of evolutionary convergence [PDF]

open access: yes, 2015
Most viruses express during infection products that prevent or neutralize the effect of the host dsRNA activated protein kinase (PKR). Translation of Sindbis virus (SINV) mRNA escapes to PKR activation and eIF2 phosphorylation in infected cells by a ...
Domingo-Gil, Elena   +4 more
core   +1 more source

Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation

open access: yesnpj Parkinson's Disease, 2019
Neuroinvasive infections with mosquito-borne alphaviruses such as Western equine encephalitis virus (WEEV) can cause post-encephalitic parkinsonism. To understand the mechanisms underlying these neurological effects, we examined the capacity of WEEV to ...
C. Bantle   +5 more
semanticscholar   +1 more source

Quantitative trait loci and genes associated with salmonid alphavirus load in Atlantic salmon: implications for pancreas disease resistance and tolerance

open access: yesScientific Reports, 2020
Salmonid alphavirus infection results in pancreas disease causing severe economic losses for Atlantic salmon aquaculture. Knowledge about genes and pathways contributing to resistance is limited.
M. L. Aslam   +8 more
semanticscholar   +1 more source

A Viral RNA Silencing Suppressor Modulates Reactive Oxygen Species Levels to Induce the Autophagic Degradation of Dicer‐Like and Argonaute‐Like Proteins

open access: yesAdvanced Science, Volume 12, Issue 44, November 27, 2025.
Understanding the virus‐host arms race has been a fascinating topic in virology; contributing significantly to the development of treatments and control strategies for viral diseases. CHV1 employs a sophisticated counter‐defense mechanism in its fungal host by utilizing a viral silencing suppressor to inhibit fungal FMN reductase; thereby modulating ...
Shiyu Zhai   +8 more
wiley   +1 more source

An alternative pathway for alphavirus entry [PDF]

open access: yesVirology Journal, 2011
Abstract The study of alphavirus entry has been complicated by an inability to clearly identify a receptor and by experiments which only tangentially and indirectly examine the process, producing results that are difficult to interpret. The mechanism of entry has been widely accepted to be by endocytosis followed by acidification of the ...
Brown Dennis T   +2 more
openaire   +3 more sources

Use of a lambda gt11 expression library to localize a neutralizing antibody-binding site in glycoprotein E2 of Sindbis virus [PDF]

open access: yes, 1991
The Sindbis virus envelope contains two species of integral membrane glycoproteins, E1 and E2. These proteins form heterodimers, and three dimeric units assemble to form spikes incorporated into the viral surface which play an important role in the ...
Strauss, James H., Wang, Kang-Sheng
core   +1 more source

An All‐in‐One Metabarcoding Approach to Mosquito and Arbovirus Xenosurveillance

open access: yesMolecular Ecology Resources, Volume 25, Issue 8, November 2025.
ABSTRACT Next‐generation sequencing (NGS) has the potential to transform mosquito‐borne disease surveillance but remains under‐utilised. This study introduces a comprehensive multi‐loci metabarcoding‐based MX (molecular xenomonitoring) approach to mosquito and arbovirus surveillance, enabling parallel identification of mosquito vectors, circulating ...
Brian J. Johnson   +12 more
wiley   +1 more source

Semliki Forest viiruse replikaasivalgu nsP1 uurimine [PDF]

open access: yes, 2013
Väitekirja elektrooniline versioon ei sisalda publikatsioone.Semliki Forest viirus kuulub alfaviiruste perekonda sugukonnas Togaviridae. Alfaviirused on olulised patogeenid ning põhjustavad erinevaid vaevusi nii loomadele kui ka inimestele.
Karo-Astover, Liis
core  

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