Results 111 to 120 of about 23,819 (265)

Self-replicating alphavirus RNA vaccines

Expert Review of Vaccines, 2014
Recombinant nucleic acids are considered as promising next-generation vaccines. These vaccines express the native antigen upon delivery into tissue, thus mimicking live attenuated vaccines without having the risk of reversion to pathogenicity. They also stimulate the innate immune system, thus potentiating responses.
Ljungberg K1, Liljeström P.
openaire   +2 more sources

Characteristics of Madariaga and Venezuelan Equine Encephalitis Virus Infections, Panama

Emerging Infectious Diseases
Madariaga virus (MADV) and Venezuelan equine encephalitis virus (VEEV) are emerging arboviruses affecting rural and remote areas of Latin America. However, clinical and epidemiologic reports are limited, and outbreaks are occurring at an increasing ...
Luis Felipe Rivera, Carlos Lezcano-Coba, Josefrancisco Galué, Xacdiel Rodriguez, Yelissa Juarez, William M. de Souza, Zeuz Capitan-Barrios, Anayansi Valderrama, Leyda Abrego, Hector Cedeño, Carmela Jackman, Jesse J. Waggoner, Patricia V. Aguilar, Hilda Guzman, Scott C. Weaver, Robert B. Tesh, Sandra López-Vèrges, Christl A. Donnelly, Cassia F. Estofolete, Mauricio L. Nogueira, Nuno R. Faria, Nikos Vasilakis, Amy Y. Vittor, Darci R. Smith, Jean-Paul Carrera   +24 more
doaj   +1 more source

Supplementary Figures 1 - 4 from Combination of Alphavirus Replicon Particle–Based Vaccination with Immunomodulatory Antibodies: Therapeutic Activity in the B16 Melanoma Mouse Model and Immune Correlates

, 2023
Francesca Avogadri, Roberta Zappasodi, Arvin Yang, Sadna Budhu, Nicole Malandro, Daniel Hirschhorn-Cymerman, Shakuntala Tiwari, Maureen F. Maughan, Robert A. Olmsted, Jedd D. Wolchok, Taha Merghoub   +10 more
openalex   +1 more source

Viruses and the cellular RNA decay machinery. [PDF]

, 2010
The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core   +1 more source

A Vaccinia Virus Recombinant Transcribing an Alphavirus Replicon and Expressing Alphavirus Structural Proteins Leads to Packaging of Alphavirus Infectious Single Cycle Particles

PLoS ONE, 2013
Poxviruses and Alphaviruses constitute two promising viral vectors that have been used extensively as expression systems, or as vehicles for vaccine purposes. Poxviruses, like vaccinia virus (VV) are well-established vaccine vectors having large insertion capacity, excellent stability, and ease of administration.
Sánchez-Puig Eyre, Juana María, Lorenzo Gilsanz, María Mar, Blasco Lozano, Rafael   +2 more
openaire   +6 more sources

Sindbis Virus Infection in Resident Birds, Migratory Birds, and Humans, Finland

Emerging Infectious Diseases, 2008
Sindbis virus (SINV), a mosquito-borne virus that causes rash and arthritis, has been causing outbreaks in humans every seventh year in northern Europe.
Satu Kurkela, Osmo Rätti, Eili Huhtamo, Nathalie Y. Uzcátegui, J. Pekka Nuorti, Juha Laakkonen, Tytti Manni, Pekka Helle, Antti Vaheri, Olli Vapalahti   +9 more
doaj   +1 more source

Alphavirus serosurvey in domestic herbivores in Pará State, Brazilian Amazon [PDF]

, 2012
Alexandre do Rosário Casseb, Jannifer Oliveira Chiang, Lívia Carício Martins, Sandro Patroca da Silva, Daniele Freitas Henriques, Lívia Medeiros Neves Casseb, Pedro Fernando da Costa Vasconcelos   +6 more
openalex   +1 more source

Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology

mBio, 2017
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade.
Jennifer E. Jones, Kristin M. Long, Alan C. Whitmore, Wes Sanders, Lance R. Thurlow, Julia A. Brown, Clayton R. Morrison, Heather Vincent, Kayla M. Peck, Christian Browning, Nathaniel Moorman, Jean K. Lim, Mark T. Heise   +12 more
doaj   +1 more source

Alphavirus Replicon Particles as Candidate HIV Vaccines [PDF]

, 2002
Nancy Davis, Ande West, Elizabeth A. Reap, Gene H. MacDonald, Martha Collier, Sergey A. Dryga, Maureen F. Maughan, Mary J. Connell, Chris Walker, Kathryn M. McGrath, Chad Cecil, Li‐Hua Ping, Jeff Frelinger, Robert A. Olmsted, Paula Keith, Ronald Swanstrom, Carolyn Williamson, Philip R. Johnson, David C. Montefiori, Robert E. Johnston   +19 more
openalex   +1 more source

Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection

Vaccines
Chikungunya virus (CHIKV) is a pathogenic arthritogenic alphavirus responsible for large-scale human epidemics for which a vaccine was recently approved for use.
Whitney C. Weber, Takeshi F. Andoh, Craig N. Kreklywich, Zachary J. Streblow, Michael Denton, Magdalene M. Streblow, John M. Powers, Gauthami Sulgey, Samuel Medica, Igor Dmitriev, David T. Curiel, Nicole N. Haese, Daniel N. Streblow   +12 more
doaj   +1 more source