Results 131 to 140 of about 28,174 (288)
Controlled Field Trial of Pancreas Disease Vaccines in Farmed Atlantic Salmon: Effects on Growth and Mortality During a SAV2 Outbreak
Journal of Fish Diseases, Volume 48, Issue 12, December 2025.ABSTRACT
Pancreas disease (PD), caused by salmonid alphavirus (SAV), is a concern for salmon aquaculture in Scotland, Ireland and Norway. This article presents results from a controlled field trial monitoring three study groups from vaccination to harvest.Jostein Mulder Pettersen, Marte Follesø Sønnervik, Marius Karlsen, Hege Jørstad Sekkenes, Geir Schriwer, Petter Gjesdal, Ane Sandtrø, Magnus Vikan Røsæg +7 morewiley +1 more sourceSNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy [PDF]
, 2017 Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes febrile disease, muscle and joint pain, which can become chronic in some individuals. The non-structural protein 3 (nsP3) plays essential roles during infection, but a complete understanding ...A Gautier, A Ivanova, A Salonen, A Utt, AC Register, AE Firth, B Meason, B Thaa, BM Kummerer, C Li, C Schilte, C Smalley, CB Muller, CJ Sheppard, D Moradpour, D Ross-Thriepland, DY Kim, E Born van den, E Frolova, E Herker, E Park, EI Frolova, F Chaumont de, FE Scholte, FE Scholte, G Camus, G Lukinavicius, G Shi, G Shin, G Yang, GP Li, H Gong, H Malet, H Nakabayashi, H Tourriere, H Vihinen, H Vihinen, H Wang, HJ Yang, I De, I Frolov, IM Cristea, J Peranen, JE Snyder, JH Strauss, JJ Fros, JJ Fros, K Bojkowska, K Onomoto, K Tsetsarkin, KM Dean, L Eckei, L Pohjala, M Eckhardt, M Neuvonen, M Neuvonen, M Ruiz-Guillen, MD Panas, MD Panas, MD Panas, ML Rajamaki, MW LaStarza, N Tamberg, NF Rose, NJ Foy, P Bieling, P Laakkonen, P Targett-Adams, R Abdelnabi, R Gorchakov, RL McPherson, S Martin, S Mueller, SC Weaver, T Ahola, T Fujimoto, T Klein, WR Hardy, Y Fujimoto, Y Miyanari, YF Wang +80 morecore +1 more sourceStructure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain
ChemBioChem, Volume 26, Issue 23, November 27, 2025.Structure‐guided design of a sulfamoyl‐modified analog of GS‐441524 yielded a selective, high‐affinity inhibitor of the SARS‐CoV‐2 macrodomain Nsp3b. The compound occupies the phosphate‐binding pocket, forming a stabilizing hydrogen‐bond network that enhances binding affinity (K_D = 0.86 μM).Robin Krishnathas, Konstantin S. Mineev, Nikolaos K. Fourkiotis, Franck Touret, Christos Sideras‐Bisdekis, Aikaterini C. Tsika, Santosh Lakshmi Gande, Verena Linhard, Sridhar Sreeramulu, Frank Lennartz, Manfred S. Weiss, Bruno Coutard, Georgios A. Spyroulias, Harald Schwalbe +13 morewiley +1 more sourceSindbis Virus Infection in Resident Birds, Migratory Birds, and Humans, Finland
Emerging Infectious Diseases, 2008 Sindbis virus (SINV), a mosquito-borne virus that causes rash and arthritis, has been causing outbreaks in humans every seventh year in northern Europe.Satu Kurkela, Osmo Rätti, Eili Huhtamo, Nathalie Y. Uzcátegui, J. Pekka Nuorti, Juha Laakkonen, Tytti Manni, Pekka Helle, Antti Vaheri, Olli Vapalahti +9 moredoaj +1 more sourceDisruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology
mBio, 2017 Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade.Jennifer E. Jones, Kristin M. Long, Alan C. Whitmore, Wes Sanders, Lance R. Thurlow, Julia A. Brown, Clayton R. Morrison, Heather Vincent, Kayla M. Peck, Christian Browning, Nathaniel Moorman, Jean K. Lim, Mark T. Heise +12 moredoaj +1 more sourceThe First Isolation of Insect-Specific Alphavirus (Agua Salud alphavirus) in Culex (Melanoconion) Mosquitoes in the Brazilian Amazon
VirusesAdvances in diagnostic techniques coupled with ongoing environmental changes have resulted in intensified surveillance and monitoring of arbovirus circulation in the Amazon.Bruna Ramos, Valéria Carvalho, Eliana da Silva, Maria Freitas, Landeson Junior Barros, Maissa Santos, Jamilla Augusta Pantoja, Ercília Gonçalves, Joaquim Nunes Neto, José Wilson Junior, Durval Vieira, Daniel Dias, Ana Cecília Cruz, Bruno Nunes, Sandro Silva, Carine Aragão, Alexandre Casseb, Lívia Martins +17 moredoaj +1 more sourceSupplementary Figures 1 - 4 from Combination of Alphavirus Replicon Particle–Based Vaccination with Immunomodulatory Antibodies: Therapeutic Activity in the B16 Melanoma Mouse Model and Immune Correlates
, 2023 Francesca Avogadri, Roberta Zappasodi, Arvin Yang, Sadna Budhu, Nicole Malandro, Daniel Hirschhorn-Cymerman, Shakuntala Tiwari, Maureen F. Maughan, Robert A. Olmsted, Jedd D. Wolchok, Taha Merghoub +10 moreopenalex +1 more sourceCharacteristics of Madariaga and Venezuelan Equine Encephalitis Virus Infections, Panama
Emerging Infectious Diseases
Madariaga virus (MADV) and Venezuelan equine encephalitis virus (VEEV) are emerging arboviruses affecting rural and remote areas of Latin America. However, clinical and epidemiologic reports are limited, and outbreaks are occurring at an increasing ...Luis Felipe Rivera, Carlos Lezcano-Coba, Josefrancisco Galué, Xacdiel Rodriguez, Yelissa Juarez, William M. de Souza, Zeuz Capitan-Barrios, Anayansi Valderrama, Leyda Abrego, Hector Cedeño, Carmela Jackman, Jesse J. Waggoner, Patricia V. Aguilar, Hilda Guzman, Scott C. Weaver, Robert B. Tesh, Sandra López-Vèrges, Christl A. Donnelly, Cassia F. Estofolete, Mauricio L. Nogueira, Nuno R. Faria, Nikos Vasilakis, Amy Y. Vittor, Darci R. Smith, Jean-Paul Carrera +24 moredoaj +1 more sourceA Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses
mSystems, 2016 Several biosafety level 3 and/or 4 (BSL-3/4) pathogens are high-consequence, single-stranded RNA viruses, and their genomes, when introduced into permissive cells, are infectious. Moreover, many of these viruses are select agents (SAs), and their genomes Lindsey A. Moser, Lisbeth Ramirez-Carvajal, Vinita Puri, Steven J. Pauszek, Krystal Matthews, Kari A. Dilley, Clancy Mullan, Jennifer McGraw, Michael Khayat, Karen Beeri, Anthony Yee, Vivien Dugan, Mark T. Heise, Matthew B. Frieman, Luis L. Rodriguez, Kristen A. Bernard, David E. Wentworth, Timothy B. Stockwell, Reed S. Shabman +18 moredoaj +1 more source
