Results 151 to 160 of about 16,243 (206)
Western Equine Encephalitis Virus in Blood Donors during Outbreak, Argentina, 2023-2024. [PDF]
Emerg Infect DisBlanco S +5 more
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Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis
Journal of Virology, 2018 Alphaviruses are transmitted to humans via bites of infected mosquitoes. Although alphaviruses have caused a wide range of outbreaks and crippling disease, the availability of licensed vaccines or antiviral therapies remains limited.
Siew-Wai Fong +2 more
exaly +2 more sources
Alphavirus Entry and Membrane Fusion
Viruses, 2010 The study of enveloped animal viruses has greatly advanced our understanding of the general properties of membrane fusion and of the specific pathways that viruses use to infect the host cell.
Maofu Liao, Margaret Kielian
exaly +2 more sources
Agua Salud alphavirus defines a novel lineage of insect-specific alphaviruses discovered in the New World [PDF]
Journal of General Virology, 2020 The genus Alphavirus harbours mostly insect- transmitted viruses that cause severe disease in humans, livestock and wildlife. Thus far, only three alphaviruses with a host range restricted to insects have been found in mosquitoes from the Old World ...
José Loaiza +2 more
exaly +3 more sources
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Animal Health Research Reviews, 2012
AbstractThe alphavirus replicon technology has been utilized for many years to develop vaccines for both veterinary and human applications. Many developments have been made to the replicon platform recently, resulting in improved safety and efficacy of replicon particle (RP) vaccines. This review provides a broad overview of the replicon technology and
Ryan L, Vander Veen +2 more
openaire +2 more sources
AbstractThe alphavirus replicon technology has been utilized for many years to develop vaccines for both veterinary and human applications. Many developments have been made to the replicon platform recently, resulting in improved safety and efficacy of replicon particle (RP) vaccines. This review provides a broad overview of the replicon technology and
Ryan L, Vander Veen +2 more
openaire +2 more sources
Alphavirus vectors and vaccination
Reviews in Medical Virology, 2002AbstractAlphaviruses are positive‐stranded RNA viruses that have a broad host range and therefore are capable of replicating in many vertebrate and invertebrate cells. The single‐stranded alphavirus genome is divided into two ORFs. The first ORF encodes the nonstructural proteins that are translated upon entry of the virus into the cytoplasm and are ...
Jonathan O, Rayner +2 more
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Alphavirus Transducing Systems
2008Alphavirus transducing systems (ATSs) are important tools for expressing genes of interest (GOI) in mosquitoes and nonvector insects. ATSs are derived from infectious cDNA clones of mosquito-borne RNA viruses (family Togaviridae). The most common ATSs in use are derived from Sindbis viruses; however, ATSs have been derived from other alphaviruses as ...
Brian D, Foy, Ken E, Olson
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Current Opinion in Biotechnology, 1994
Alphavirus vectors are newcomers in the field of heterologous gene expression. Nevertheless, they have rapidly become popular and are now being used in a wide range of applications. During the past year, new vectors and new methods for their use have improved levels of gene expression.
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Alphavirus vectors are newcomers in the field of heterologous gene expression. Nevertheless, they have rapidly become popular and are now being used in a wide range of applications. During the past year, new vectors and new methods for their use have improved levels of gene expression.
openaire +2 more sources
BST2/Tetherin Inhibition of Alphavirus Exit
Viruses, 2015 Alphaviruses such as chikungunya virus (CHIKV) and Semliki Forest virus (SFV) are small enveloped RNA viruses that bud from the plasma membrane. Tetherin/BST2 is an interferon-induced host membrane protein that inhibits the release of many enveloped ...
Yaw Shin Ooi +2 more
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Purification and Concentration of Alphavirus
Cold Spring Harbor Protocols, 2012The alphaviruses Semliki Forest virus and Sindbis virus have been used frequently as expression vectors in vitro and in vivo. Usually, these systems consist of replication-deficient vectors that require a helper vector for packaging of recombinant particles. Replication-proficient vectors have also been engineered.
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