Results 171 to 180 of about 13,766 (218)

Defining the impact of Getah virus envelope protein glycosylation site mutations on viral replication, host adaptation, virulence, and immune evasion. [PDF]

PLoS Pathog
Ren T, Liu M, Li P, Zhang L, Zhong Z, Zhou L, Qin Y, Ouyang K, Yin Y, Chen Y, Huang W, Wei Z.   +11 more
europepmc   +1 more source

Old World alphaviruses use distinct mechanisms to infect brain microvascular endothelial cells for neuroinvasion. [PDF]

Cell Rep
Alvarez PA, Tang A, Winters DM, Kaushal P, Medina A, Nieto MV, Kaczor-Urbanowicz KE, St Amant F, Reyes BR, Kaake RM, Fregoso OI, Pyle AD, Bouhaddou M, Tang H, Li MMH.   +14 more
europepmc   +1 more source

Seasonal Dynamics of Human IgG Antibody Responses to Aedes Nterm-34kDa Peptide as a Biomarker of Alphavirus and Flavivirus Transmission in Northern Tanzania

Kajeguka DC, Kulaya N, Issangya ET, Emidi B, Kassam NA, Elanga-Ndille E.   +5 more
europepmc   +1 more source

Discovery of Mwinilunga alphavirus: A novel alphavirus in Culex mosquitoes in Zambia [PDF]

Virus Research, 2018
Mosquito-borne alphaviruses are disseminated globally and cause febrile illness in humans and animals. Since the prevalence and diversity of alphaviruses has not been previously investigated in Zambia, reverse transcription PCR was employed as a broad-spectrum approach for the detection of alphaviruses in mosquitoes.
Yongjin Qiu, Masahiro Kajihara, Paulina Duhita Anindita   +2 more
exaly   +4 more sources

Alphavirus Entry and Membrane Fusion [PDF]

Viruses, 2010
The study of enveloped animal viruses has greatly advanced our understanding of the general properties of membrane fusion and of the specific pathways that viruses use to infect the host cell. The membrane fusion proteins of the alphaviruses and flaviviruses have many similarities in structure and function.
Maofu Liao, Margaret Kielian, Kielian Margaret   +2 more
exaly   +4 more sources

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Alphavirus replicon vaccines

Animal Health Research Reviews, 2012
AbstractThe alphavirus replicon technology has been utilized for many years to develop vaccines for both veterinary and human applications. Many developments have been made to the replicon platform recently, resulting in improved safety and efficacy of replicon particle (RP) vaccines. This review provides a broad overview of the replicon technology and
Ryan L, Vander Veen, D L Hank, Harris, Kurt I, Kamrud   +2 more
openaire   +2 more sources

Alphavirus vectors and vaccination

Reviews in Medical Virology, 2002
AbstractAlphaviruses are positive‐stranded RNA viruses that have a broad host range and therefore are capable of replicating in many vertebrate and invertebrate cells. The single‐stranded alphavirus genome is divided into two ORFs. The first ORF encodes the nonstructural proteins that are translated upon entry of the virus into the cytoplasm and are ...
Jonathan O, Rayner, Sergey A, Dryga, Kurt I, Kamrud   +2 more
openaire   +2 more sources

Alphavirus Nucleocapsid Packaging and Assembly [PDF]

Viruses, 2018
Alphavirus nucleocapsids are assembled in the cytoplasm of infected cells from 240 copies of the capsid protein and the approximately 11 kb positive strand genomic RNA. However, the challenge of how the capsid specifically selects its RNA package and assembles around it has remained an elusive one to solve.
Richard Kuhn, Adriano Mendes, Kuhn Richard J   +2 more
exaly   +4 more sources