Results 141 to 150 of about 28,174 (288)
Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion. [PDF]
, 2016 The host responds to virus infection by activating type I interferon (IFN) signaling leading to expression of IFN-stimulated genes (ISGs). Dysregulation of the IFN response results in inflammatory diseases and chronic infections.
Bozzacco, Leonia +8 more
core
The growth of arthralgic Ross River virus is restricted in human monocytic cells [PDF]
, 2016 International audienceAlphaviruses such as Chikungunya and Ross River (RRV) viruses are associated with persistent arthritisand arthralgia in humans. Monocytes and macrophages are believed to play an important role in alphaviralarthritides. In this study,
Belarbi, Essia +7 more
core +2 more sources
Self-replicating alphavirus RNA vaccines
Expert Review of Vaccines, 2014 Recombinant nucleic acids are considered as promising next-generation vaccines. These vaccines express the native antigen upon delivery into tissue, thus mimicking live attenuated vaccines without having the risk of reversion to pathogenicity. They also stimulate the innate immune system, thus potentiating responses.
Ljungberg K1, Liljeström P.
openaire +2 more sources
Alphavirus Replicon Particles as Candidate HIV Vaccines [PDF]
, 2002 Nancy Davis +19 more
openalex +1 more source
PLoS ONE, 2013 Poxviruses and Alphaviruses constitute two promising viral vectors that have been used extensively as expression systems, or as vehicles for vaccine purposes. Poxviruses, like vaccinia virus (VV) are well-established vaccine vectors having large insertion capacity, excellent stability, and ease of administration.
Sánchez-Puig Eyre, Juana María +2 more
openaire +6 more sources
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs [PDF]
, 2016 Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication ...
Berre, Stefano +16 more
core +5 more sources
Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection
VaccinesChikungunya virus (CHIKV) is a pathogenic arthritogenic alphavirus responsible for large-scale human epidemics for which a vaccine was recently approved for use.
Whitney C. Weber +12 more
doaj +1 more source
Expression kinetics and innate immune response after electroporation and LNP-mediated delivery of a self-amplifying mRNA in the skin [PDF]
, 2019 In this work, we studied the expression kinetics and innate immune response of a self-amplifying mRNA (sa-RNA) after electroporation and lipid-nanoparticle (LNP)-mediated delivery in the skin of mice. Intradermal electroporation of the sa-RNA resulted in
De Temmerman, Joyca +8 more
core +2 more sources
npj Parkinson's Disease, 2019 Neuroinvasive infections with mosquito-borne alphaviruses such as Western equine encephalitis virus (WEEV) can cause post-encephalitic parkinsonism. To understand the mechanisms underlying these neurological effects, we examined the capacity of WEEV to ...
C. Bantle +5 more
semanticscholar +1 more source
A Fully Attenuated Recombinant Salmonid Alphavirus Becomes Pathogenic through a Single Amino Acid Change in the E2 Glycoprotein [PDF]
, 2013 Emilie Mérour +4 more
openalex +1 more source