Results 201 to 210 of about 15,250 (221)
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REGULATORS OF APOPTOSIS ON THE ROAD TO PERSISTENT ALPHAVIRUS INFECTION
Annual Review of Microbiology, 1997▪ Abstract Alphavirus infection can trigger the host cell to activate its genetically programmed cell death pathway, leading to the morphological features of apoptosis. The ability to activate this death pathway is dependent on both viral and cellular determinants. The more virulent strains of alphavirus induce apoptosis with increased efficiency both
D E, Griffin, J M, Hardwick
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Arthritis Associated with Alphavirus Infections: Dengue and Zika
2019Dengue virus (DENV) and Zika virus (ZIKV) are a cause of significant morbidity and mortality worldwide within specific regions of the world where they are endemic and susceptible to the occurrence of epidemics. The interaction between these viruses and other host factors (especially the immunocompetence) seems to influence the expression and severity ...
Sergio Miguel Angel Toloza +1 more
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Age-dependent susceptibility to fatal encephalitis: alphavirus infection of neurons
1994Sindbis virus encephalitis in mice provides a model for studying age-dependent susceptibility to acute viral encephalitis. The AR339 strain of SV causes fatal encephalitis in newborn mice, but weanling mice recover uneventfully. Increased virulence for older mice is associated with a single amino acid change from Gln to His at position 55 of the E2 ...
D E, Griffin +4 more
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A molecular understanding of alphavirus entry and antibody protection
Nature Reviews Microbiology, 2022Arthur S Kim, Michael Diamond
exaly
Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress
Cell, 2021Lauren E Williamson +2 more
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Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope
Cell, 2021Arthur S Kim +2 more
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Processing of alphavirus-specific proteins in infected cells.
Medical biology, 1976The RNA of the alphaviruses contains the genetic information for both the non-structural and the structural polypeptides. The former are contained in the initial two-thirds of the sequence (from the 5'-terminus) and are read directly from the virus particle RNA, but whether post-translational cleavage is involved or not is not known.
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