Results 71 to 80 of about 10,706 (212)

25-Hydroxyvitamin D-3 induces osteogenic differentiation of human mesenchymal stem cells [PDF]

, 2016
25-Hydroxyvitamin D-3 [25(OH)D-3] has recently been found to be an active hormone. Its biological actions are demonstrated in various cell types. 25(OH)D-3 deficiency results in failure in bone formation and skeletal deformation.
Lou, Yan-Ru, Tee, Yee Han, Toh, Tai Chong, Yu, Hanry   +3 more
core   +1 more source

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes

Current Issues in Pharmacy and Medical Sciences, 2014
In adult life, proper bone metabolism requires efficient regulation of bone formation and resorption processes. Bone turnover markers allow for assessing the rate of bone formation and resorption processes.
Rahnama Mansur, Lobacz Michal, Szyszkowska Anna, Trybek Grzegorz, Kozicka-Czupkallo Maryla   +4 more
doaj   +1 more source

The Effect of Asfotase Alfa on Plasma and Urine Pyrophosphate Levels and Pseudofractures in a Patient With Adult‐Onset Hypophosphatasia

JBMR Plus, 2023
Hypophosphatasia (HPP) is an inherited disease caused by variants of the ALPL gene encoding tissue‐nonspecific alkaline phosphatase. Adult‐onset HPP (adult HPP), known as a mild form of HPP, develops symptoms involving osteomalacia after the age of 18 ...
Naoko Hidaka, Hiroaki Murata, Kanako Tachikawa, Keiichi Osaki, Takashi Sekiyama, Yuka Kinoshita, Hajime Kato, Yoshitomo Hoshino, Soichiro Kimura, Takashi Sunouchi, So Watanabe, Masaomi Nangaku, Noriko Makita, Toshimi Michigami, Nobuaki Ito   +14 more
doaj   +1 more source

Pharmacological Inhibition of PHOSPHO1 Suppresses Vascular Smooth Muscle Cell Calcification [PDF]

, 2013
Medial vascular calcification (MVC) is common in patients with chronic kidney disease, obesity, and aging. MVC is an actively regulated process that resembles skeletal mineralization, resulting from chondro-osteogenic transformation of vascular smooth ...
Chen, Chung, Ciancaglini, Dahl, Delomenede, Doherty, El-Abbadi, Fleisch, Gremse, Grosdidier, Grosdidier, Harmey, Hessle, Houston, Houston, Hsu, Huesa, Jaroszewski, Johnson, Jono, Kapustin, Kozlenkov, Lomashvili, Lyemere, MacRae, Markello, Nakano-Kurimoto, Narisawa, O'Neill, Qiao, Roberts, Roberts, Roy, Schwede, Sergienko, Sergienko, Shanahan, Shroff, Sidique, Stewart, Stewart, Towler, Towler, Tyson, van der Zee, Villa-Bellosta, Yadav, Zhu   +47 more
core   +1 more source

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Generation of a new human iPSC cell line (UOMi010-A) from a patient with hypophosphatasia

Stem Cell Research
Hypophosphatasia (HPP) is characterized by loss of function variants in the alkaline phosphatase (ALPL) gene that leads to impaired mineralization in bones and teeth.
Abhay Srivastava, Dylan Walker, Jason Uzonna, Cheryl Rockman-Greenberg, Sanjiv Dhingra   +4 more
doaj   +1 more source

Charakterisierung molekulargenetischer Prognosefaktoren auf dem kurzen Arm des Chromosoms 1 in humanen Meningeomen. [PDF]

, 2004
Meningeome, zumeist benigne Neoplasien des ZNS, stellen bis heute in manchen Fällen eine diagnostische und therapeutische Herausforderung dar: Zum einen ist für die kleine Gruppe der atypischen und anaplastischen Tumoren das Grading aufgrund ...
Bertalanffy, Helmut (Prof. Dr. med.), Lindner, Christine   +1 more
core   +1 more source

Clinical and ALPL Gene Mutations Analysis in an Early Onset Chinese Odontohypophosphatasia Patient

American Journal of Biomedical Sciences, 2014
Objective: To describe a Chinese case with novel frame shift ALPL gene mutation that results in infantile onset odontohypophosphatasia. Methods: Clinical data and genomic DNA of the patient and his parents were collected. Alkaline phosphatase gene (ALPL)of the patient and his parents were PCR following with sequencing.
Xuejun Liang, Min Liu, Chunxiu Gong
openaire   +1 more source

Incidence of Mutations in the ALPL, GGPS1, and CYP1A1 Genes in Patients With Atypical Femoral Fractures [PDF]

JBMR Plus, 2018
ABSTRACTAtypical femoral fractures (AFFs) are uncommon and often related to prolonged bisphosphonate (BP) treatment. Isolated cases have been linked to mutations of tissue nonspecific alkaline phosphatase (ALPL). Moreover, mutations in the geranylgeranyl pyrophosphate synthase (GGPPS) gene, which can be inhibited by BPs, and in the enzyme of the ...
Peris, Pilar, González‐Roca, Eva, Rodríguez‐García, Sebastian C, del Mar López‐Cobo, María, Monegal, Ana, Guañabens, Núria   +5 more
openaire   +2 more sources