Results 61 to 70 of about 1,930 (207)

ALPPS readdresses the management of advanced liver tumors

, 2017
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been developed to induce rapid liver hypertrophy of the future liver remnant (FLR) prior to hepatectomy in primarily non-resectable or marginally resectable liver ...
Jun Kong, Fa-guang Huang, Jian Ping Gong, Jiang-Hua Xiao   +3 more
core   +1 more source

Flow Cytometric Detection of Biomarker Changes in CFDA‐SE‐Labelled Plasma Extracellular Vesicles Using a Rodent Pregnancy Model of Prenatal Diagnostics

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Circulating extracellular vesicles (EVs) offer a promising source of non‐invasive biomarkers for congenital disease diagnostics but robust assays for their detection are lacking. We used a rodent pregnancy model as a proxy for a prenatal diagnostics assay to test whether we could detect a difference in EV tetraspanin display between pregnant ...
Petra Adamova, Lesley Sloan, Andrew K. Powell, Iain M. Dykes   +3 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, Volume 20, Issue 4, Page 995-1007, April 2026.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Engineered TIGIT‐Blockade Membrane Vesicles Synergize with Microwave Ablation to Mediate Liver Metastases Eradication

Advanced Science, Volume 13, Issue 22, 17 April 2026.
Microwave ablation (MWA) represents a highly effective and clinically significant therapeutic modality for the treatment of liver metastases. This study develops engineered cell membrane vesicles to specifically target the transition zone of MWA for liver metastases. This strategy can inhibit VEGF‐mediated immunosuppression, block CD155/TIGIT signaling
Shaoyue Li, Weichen Xu, Yuting Shen, Xuexia Shan, Jiawei Sun, Shisi Ding, Xiaodong Hou, Shaoning Zhang, Zhiyuan Niu, Taixia Wang, Xin Guan, Xiao Li, Weiwei Ren, Dou Du, Huixiong Xu, Wenwen Yue, Liping Sun   +16 more
wiley   +1 more source

Liver growth prediction in ALPPS – A multicenter analysis from the international ALPPS registry

Liver International, 2022
AbstractBackgroundWhile ALPPS triggers a fast liver hypertrophy, it is still unclear which factors matter most to achieve accelerated hypertrophy within a short period of time. The aim of the study was to identify patient‐intrinsic factors related to the growth of the future liver remnant (FLR).MethodsThis cohort study is composed of data derived from ...
Lopez-Lopez, Victor, Linecker, Michael, Cruz, Juan, Brusadin, Roberto, Lopez-Conesa, Asuncion, Machado, Marcel Autran, Hernandez-Alejandro, Roberto, Voskanyan, Alejandro Sergey, Li, Jun, Balci, Deniz, Adam, René, Ardiles, Victoria, De Santibañes, Eduardo, Tomassini, Federico, Troisi, Roberto I, Lurje, Georg, Truant, Stéphanie, Pruvot, Francois-René, Björnsson, Bergthor, Stojanovic, Miroslav, Montalti, Roberto, Cayuela, Valentin, Kozyrin, Ivan, Cai, Xiujun, de Vicente, Emilio, Rauchfuss, Falk, Lodge, Peter, Ratti, Francesca, Aldrighetti, Luca, Oldhafer, Karl J, Malago, Massimo, Petrowsky, Henrik, Clavien, Pierre-Alain, Robles-Campos, Ricardo   +33 more
openaire   +3 more sources

Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence

Animal Models and Experimental Medicine, Volume 9, Issue 4, Page 796-808, April 2026.
The pathogenesis of stress urinary incontinence (SUI) is intimately associated with injury to the external urethral sphincter (EUS). In this study, we established an SUI model induced by double vaginal distension and demonstrated that metformin treatment activated the AMPK signaling in the EUS tissue.
Yuting Xu, Xuhong Li, Alvaro Munoz, Li Jiang, Lihua Huang, Yanhua Zhou, Liping Zhu, Youbo Yang   +7 more
wiley   +1 more source

Associating liver partition and portal vein ligation for staged hepatectomy versus conventional two-stage hepatectomy: a systematic review and meta-analysis

World Journal of Surgical Oncology, 2017
Background It is generally accepted that an insufficient future liver remnant is a major limitation of large-scale hepatectomy for patients with primary hepatocellular carcinoma.
Zheng Zhou, Mingxing Xu, Nan Lin, Chuzhi Pan, Boxuan Zhou, Yuesi Zhong, Ruiyun Xu   +6 more
doaj   +1 more source

Mineralized Cryogel/Hydrogel Constructs to Recapitulate Early Breast Cancer Bone Metastasis In Vitro

Advanced Science, Volume 13, Issue 18, 27 March 2026.
A new biphasic in vitro cryogel/hydrogel model of early breast cancer bone metastasis provides precise control over microenvironmental cues and microscopic access to the spatiotemporal cancer cell distribution. Deposited bone‐like mineral is observed to strongly impede the effects of biomolecular signals, as evidenced by both colonization profiles and ...
Jana Sievers‐Liebschner, Petra B. Welzel, Maximilian Fusenig, Linda Sturm, Dagmar Pette, Wolfgang Wagermaier, Claudia Fischbach, Peter Fratzl, Carsten Werner   +8 more
wiley   +1 more source

Long-Term Follow-Up of Patients with Advanced Colorectal Liver Metastasis: A Survival Analysis from the Randomized Controlled Multicenter Trial LIGRO

Annals of Surgery Open
Objective:. The objective of this study was to evaluate the long-term oncological outcomes of patients with colorectal liver metastasis (CRLM) randomized for associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) or 2-stage ...
Dennis Björk, MD, Kristina Hasselgren, MD, PhD, Bård I. Røsok, MD, PhD, Peter N. Larsen, MD, PhD, Ernesto Sparrelid, MD, PhD, Gert Lindell, MD, PhD, Nicolai A. Schultz, MD, PhD, Bjorn A. Bjørnbeth, MD, PhD, Bengt Isaksson, MD, PhD, Anna Lindhoff Larsson, RN, Magnus Rizell, MD, PhD, Bergthor Björnsson, MD, PhD, Per Sandström, MD, PhD   +12 more
doaj   +1 more source

ALPPS for cirrhotic liver

Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) has been regarded as one of the most novel procedures for flow modulation in future liver remnant in recent years. The initial results for ALPPS procedure were criticized
Chan, Albert Chi Yan, Au, Kin Pan
core   +1 more source