Results 1 to 10 of about 3,505,696 (258)

Förderung digitalisierungsbezogener Kompetenzen in der sprachlichen Bildung bei Lehramtsstudierenden

Herausforderung Lehrer*innenbildung, 2023
Im Kontext der Digitalisierung obliegt es Lehrkräften als fächerübergreifende Querschnittsaufgabe, digitale Tools auch zur Unterstützung des sprachlichen Lernens von Schüler*innen einzusetzen.
Cedric Lawida, Janna Gutenberg, Christoph Gantefort   +2 more
doaj   +1 more source

A machine-learning based objective measure for ALS disease severity

npj Digital Medicine, 2022
Amyotrophic Lateral Sclerosis (ALS) disease severity is usually measured using the subjective, questionnaire-based revised ALS Functional Rating Scale (ALSFRS-R).
Fernando G. Vieira, Subhashini Venugopalan, Alan S. Premasiri, Maeve McNally, Aren Jansen, Kevin McCloskey, Michael P. Brenner, Steven Perrin   +7 more
doaj   +1 more source

Effects of intracellular calcium accumulation on proteins encoded by the major genes underlying amyotrophic lateral sclerosis

Scientific Reports, 2022
The aetiology of Amyotrophic Lateral Sclerosis (ALS) is still poorly understood. The discovery of genetic forms of ALS pointed out the mechanisms underlying this pathology, but also showed how complex these mechanisms are.
Giovanni De Marco, Annarosa Lomartire, Umberto Manera, Antonio Canosa, Maurizio Grassano, Federico Casale, Giuseppe Fuda, Paolina Salamone, Maria Teresa Rinaudo, Sebastiano Colombatto, Cristina Moglia, Adriano Chiò, Andrea Calvo   +12 more
doaj   +1 more source

Trace and major elements in food supplements of different origin: Implications for daily intake levels and health risks

Toxicology Reports, 2021
As the use of food supplements increases, voices are being raised questioning the safety of these products. As a contribution to understanding the trace and major elemental composition of food supplements and their potential health risks, this study ...
A. Augustsson, A. Qvarforth, E. Engström, C. Paulukat, I. Rodushkin   +4 more
doaj   +1 more source

The impact of respite care from the perspectives and experiences of people with amyotrophic lateral sclerosis and their care partners: a qualitative study

BMC Palliative Care, 2022
Background Respite care provides caregiving support to people with amyotrophic lateral sclerosis (ALS) and their care partners by providing the care partner with temporary relief from their caregiving duties.
Julia M. Wu, Mallorie T. Tam, Kirsten Buch, Fouziah Khairati, Laurissa Wilson, Elizabeth Bannerman, Alexandra Guerrero, Andrew Eisen, Wendy Toyer, Travis Stevenson, Julie M. Robillard   +10 more
doaj   +1 more source

The role of peripheral immunity in ALS: a population‐based study

Annals of Clinical and Translational Neurology, 2023
Background Systemic inflammation has been proposed as a relevant mechanism in amyotrophic lateral sclerosis (ALS). Still, comprehensive data on ALS patients' innate and adaptive immune responses and their effect on the clinical phenotype are lacking ...
Maurizio Grassano, Umberto Manera, Fabiola De Marchi, Paolo Cugnasco, Enrico Matteoni, Margherita Daviddi, Luca Solero, Alessandro Bombaci, Francesca Palumbo, Rosario Vasta, Antonio Canosa, Paolina Salamone, Giuseppe Fuda, Federico Casale, Letizia Mazzini, Andrea Calvo, Cristina Moglia, Adriano Chiò   +17 more
doaj   +1 more source

A comprehensive Review of Amyotrophic Lateral Sclerosis Including: Prevalence, Pathogenesis, Biomarkers Diagnosis, and Current Treatment Options [PDF]

Reviews in Clinical Medicine, 2021
Amyotrophic lateral sclerosis (ALS) also known as motor neuron disease is a destroying neurodegenerative disease that mainly affects the upper and lower motor neurons.
Najmeh Malekzadeh
doaj   +1 more source

Extracellular vesicle-based therapy for amyotrophic lateral sclerosis

Brain Circulation, 2021
Amyotrophic lateral sclerosis (ALS) stands as a neurodegenerative disorder characterized by the rapid progression of motor neuron loss in the brain and spinal cord. Unfortunately, treatment options for ALS are limited, and therefore, novel therapies that
Nadia Sadanandan, Jea-Young Lee, Svitlana Garbuzova-Davis   +2 more
doaj   +1 more source

Matrix Factorization Based Recommendation System using Hybrid Optimization Technique [PDF]

EAI Endorsed Transactions on Energy Web, 2021
In this paper, a matrix factorization recommendation algorithm is used to recommend items to the user by inculcating a hybrid optimization technique that combines Alternating Least Squares (ALS) and Stochastic Gradient Descent (SGD) in
P. Rao, T.V. Rao, Suresh Kurumalla, Bethapudi Prakash   +3 more
doaj   +1 more source

Biomarkers and molecular mechanisms of Amyotrophic Lateral Sclerosis

AIMS Neuroscience, 2022
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in adults involving non-demyelinating motor disorders. About 90% of ALS cases are sporadic, while 10–12% of cases are due to some genetic reasons.
Ashok Chakraborty, Anil Diwan
doaj   +1 more source