Results 91 to 100 of about 30,176 (297)

Prospects for the Therapeutic Potential of Inhibitors Targeting JNK and p53 in Alzheimer's Disease

, 2023
Background: It is promising to search for fundamentally new approaches to the treatment of Alzheimer's disease (AD) within the framework of creating methods for stimulating neurogenesis and developing a strategy for targeted pharmacological regulation of
Chayikovskyi, Alexander, Miroshnichenko, Larisa, Kotlovskaya, Larisa, Zyuz`kov, Gleb   +3 more
core   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

PPARgamma als molekulares Target epithelialer Funktionen im Intestinaltrakt

, 2008
Disruption of the complex gastrointestinal ecosystem between the resident microflora and the colonic epithelial cells has been associated with increased inflammation and altered cell growth. Possible endpoints of this disturbance are IBD and CRC.
Schwab, Markus
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Fitness costs of susceptible and resistant radish biotypes to ALS-inhibitor herbicides

Comunicata Scientiae, 2018
Radish is an important weed that causes yield reduction in winter crops in southern Brazil. The control chemical of radish is an important and essential step to prevent damage on crops. However the intensive use of ALS-inhibitors herbicides favors the selection resistant biotypes.
Cechin, Joanei, Vargas, Leandro, Agostinetto, Dirceu, Zimmer, Vinicius, Pertile, Mariane, Dal Magro, Taisa   +5 more
openaire   +2 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Examination of new proteasome inhibitors

, 2010
Das Proteasom spielt eine zentrale Rolle bei der intrazellulären Proteindegradation. Proteasominhibitoren werden zur Erforschung des Ubiquitin- Proteasom-Systems eingesetzt und finden klinische Anwendung in der antineoplastischen Therapie. Perspektivisch
Wigand, Moritz Eric
core   +1 more source

Resistance to ALS inhibitors in rice in north-western Italy

, 1999
In Europe, 10 weed species have developed resistance to acetolactate synthase (ALS) inhibiting herbicides. Currently, the most serious problems with ALS resistance are found in paddy rice. The situation in Italy is presented: two weed species (Alisma plantago-aquatica and Scirpus mucronatus) in rice, that are among the most sensitive to ALS inhibitors,
Sattin M, Berto D, Zanin G, Tabacchi M
openaire   +3 more sources