Results 111 to 120 of about 30,176 (297)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Resistance to Amino Acid Biosynthesis Inhibiting-Herbicides in Amaranthus palmeri Populations from Aragon (Spain)

open access: yesPlants
Amaranthus palmeri is a highly problematic agricultural weed due to its rapid growth, high seed production, and strong tendency to develop herbicide resistance. In Spain, the initial colonization of A.
Eneko Trebol-Aizpurua   +6 more
doaj   +1 more source

Corrosion Protection of Al Alloys: Organic Coatings and Inhibitors [PDF]

open access: yes, 2012
Aluminium and its alloys have excellent durability and corrosion resistance, but, like most materials, their behaviour can be influenced by the way in which they are used. Aluminium is commercially important metal and its alloys are widely used in many industries such as reaction vessels, pipes, machinery and chemical batteries because of their ...
openaire   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Targeting BCL-2 in Hematological Cancers: Computational Screening of Cucurbitacins as Promising Inhibitors

open access: yes
Background: Disrupting the balance between cell proliferation and death is critical in cancer formation. Increased resistance to apoptosis, which is frequently caused by BCL-2 overexpression, is a critical oncogenic mechanism in many hematologic ...
Alhakami, Fatemah Abdulaziz
core   +2 more sources

Novel Metal Complexes as Protein Kinase Inhibitors

open access: yes, 2012
Diese Arbeit beschäftigt sich mit der Entwicklung neuer Pharmakophorliganden zur Darstellung verschiedener Metallkomplexe, die die ATP-Bindungstasche von Proteinkinasen adressieren und somit als ATP-kompetitive Inhibitoren wirken. Hierbei besetzt der neu
Blanck, Sebastian
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Noxious Weed Species Monochoria vaginalis Resistant to Synthetic Auxin and Acetolactate Synthase Inhibitor Herbicides

open access: yesCaraka Tani: Journal of Sustainable Agriculture
Monochoria vaginalis (Burm. f.) C. Presl is a dominant weed in paddy rice cultivation, significantly threatening productivity and farming sustainability.
Ryan Widianto, Denny Kurniadie
doaj   +1 more source

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