Results 131 to 140 of about 30,176 (297)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

First dicotyledonous in Spain with metabolic and target-site resistance to ALS inhibitors: Papaver rhoeas

, 2017
Comunicación presentada al XVI Congreso de la Sociedad Española de Malherbología, celebrado en la Universidad Pública de Navarra, Pamplona-Iruña, entre los días 25 y 27 de octubre de 2017.Se han detectado seis sustituciones diferentes en la posición ...
Rey Caballero, Jordi, Menéndez, Julio, Salas, Marisa, Torra, Joel, Osuna, María Dolores   +4 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Sepiapterin reductase inhibitors

Inhibitors of sepiapterin reductase and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and immune cell regulation are disclosed.AVP-R-TTOLIPAlternative title(s) : (de) Heteroarylderivate ...
Gorska, Katarzyna Irena, Johnsson, Kai Peter, Meniconi, Mirco, Bromidge, Steven Mark, Kerry, Mark, Peng, Hairuo, Saiah, Eddine, Mccall, John Michael, Atton, Holly Victoria, Kotey, Adrian Kotei, Monck, Nathaniel J, Avery, Craig, Tebbe, Mark Joseph, Ridgill, Mark Peter, Tye, Heather   +14 more
core  

In-vitro and in-silico studies based discovery of 2-aryl-N-(4-morpholinophenyl)thiazol-4-amines as promising DNA gyrase inhibitors

Background: DNA gyrase is an important enzyme for the survival of bacteria. Many DNA gyrase inhibitors are in clinical practice. However, these inhibitors also encompass certain toxic and drug/food interactions.
Alfrah, Samr Fahed, Alanazi, Reem Saleh, Alanazi, Rakan Khalid, Alshammri, Osama Muqbil, Albasha, Feras Salah, Alfarh, Khattab Fahed, ., Abida, Alshammari, Abdulaziz Khalaf, Alsaeed, Sumaih Saeed, Alhulayfi, Hanan Furayj, Asdaq, Syed Mohammed Basheeruddin, Imran, Mohd.   +11 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia) [PDF]

, 1980
Fritz, Hans
core   +1 more source

Can resistance to ALS-inhibitors be reversed? The PURE approach

, 2013
The widespread use of ALS inhibitors and consequent increase of resistance to this herbicide group prompts new studies on the population dynamics of ALS resistant and susceptible biotypes to check whether the resistance evolution process may be reversed.
Panozzo S, Rosan V, Scarabel L, Sattin M
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Identification of phytochemicals as potential inhibitors of Candida albicans SAP3: An in-silico approach

Background: Candida albicans is a major threat to human health, causing a variety of diseases. Candida albicans can overgrow and trigger infections like thrush, diaper rash, and vaginal yeast infections.
Alhindi, Zain
core   +2 more sources