NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II trials [PDF]
, 2008 <p><b>Background and Purpose:</b> In animal models of acute ischemic stroke (AIS), the free radical-trapping agent NXY-059 showed promise as a neuroprotectant.
Alderfer, V. +11 more
core +1 more source
Effect of alteplase on platelet function and receptor expression
Journal of International Medical Research, 2019 Objective To investigate the role of alteplase, a widely-used thrombolytic drug, in platelet function. Methods Human platelets were incubated with different concentrations of alteplase followed by analysis of platelet aggregation in response to adenosine
Jun Lu +5 more
doaj +1 more source
Neurology and Therapy, 2023 Introduction This study aimed to investigate the long-term prognostic effects of different alteplase doses on patients with acute ischemic stroke (AIS). Methods In this cohort study, we enrolled 501 patients with AIS treated with intravenous thrombolysis
Mingfeng Zhai +9 more
doaj +1 more source
Effects of alteplase for acute stroke according to criteria defining the European Union and United States marketing authorizations: individual-patient-data meta-analysis of randomized trials [PDF]
, 2017 Background: The recommended maximum age and time window for intravenous alteplase treatment of acute ischemic stroke differs between the Europe Union and United States.
Colin Baigent +28 more
core +5 more sources
Does hemispheric lateralization influence functional and cardiovascular outcomes after stroke?: an analysis of placebo-treated patients from prospective acute stroke trials [PDF]
, 2008 <p><b>Background and Purpose:</b> The influence of stroke lateralization on functional and cardiovascular outcome after stroke is not well established.
Fink, J.N. +3 more
core +1 more source
No space Left for Intravenous thrombolysis in acute stroke [PDF]
, 2016 Recent successful clinical trials of endovascular thrombectomy for large artery ischaemic stroke have established the value of this treatment modality as an adjunct to intravenous thrombolysis, not as an alternative: thrombectomy delivery was undertaken ...
Muir, Keith
core +1 more source
Additional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial [PDF]
, 2006 <p><b>Background and Purpose:</b> NXY-059 is a free radical-trapping neuroprotectant demonstrated to reduce disability from ischemic stroke. We conducted analyses on additional end points and sensitivity analyses to confirm our findings.
Ashwood, T. +11 more
core +1 more source
Using alteplase nephrostomy tube installation for thrombolysis of ureter tract clot obstruction
Urology Case Reports, 2021 In literature, few cases have been reported regarding the use of alteplase installation in a nephrostomy as anticoagulant treatment of blood clots in the upper urinary tract.Our case -report provides a unique case of alteplase installation in the ...
Paoyan Lin +2 more
doaj +1 more source
Mismatch-based delayed thrombolysis: a meta-analysis [PDF]
, 2010 <p><b>Background and Purpose</b>: Clinical benefit from thrombolysis is reduced as stroke onset to treatment time increases. The use of "mismatch" imaging to identify patients for delayed treatment has face validity and has been used in
Anthony J. Furlan +6 more
core +1 more source
Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset [PDF]
, 2010 <p><b>Background and Purpose:</b> Antiplatelets (APs) may increase the risk of symptomatic intracerebral hemorrhage (ICH) following intravenous thrombolysis after ischemic stroke.</p> <p><b>Methods:</b> We ...
Ahmed, N. +10 more
core +2 more sources