Results 11 to 20 of about 10,399 (159)

Comparative Effectiveness of Intravenous Tenecteplase versus Alteplase in Posterior Circulation Ischemic Stroke: A Systematic Review and Meta‐Analysis [PDF]

Brain Behav
Visual summary of the comparative efficacy and safety of intravenous tenecteplase versus alteplase in posterior circulation ischemic stroke. ABSTRACT Background Posterior circulation ischemic stroke (PCIS) is associated with substantial morbidity and mortality, and the optimal intravenous thrombolytic strategy in this subgroup remains unclear.
Shafiq S, Uddin A, Hussain M, Khan G, Hassan M, Razzak M, Majid M, Islam F, Ahmed U, Uddin A, Aminpoor H, Ahmed M.   +11 more
europepmc   +2 more sources

NIHSS and Large Artery Atherosclerosis Affect Efficacy of Dual Antiplatelet Therapy Versus Alteplase for Minor Stroke [PDF]

Brain Behav
ABSTRACT Background Dual antiplatelet therapy (DAPT) was noninferior to alteplase in nondisabling minor stroke (NIHSS 0 to 5). Given potential benefit of DAPT in minor stroke with large artery atherosclerosis (LAA) and of alteplase in stroke with NIHSS 4–5, we hypothesize that neurological deficit and LAA may affect efficacy of DAPT versus alteplase in
Cui Y, Li Z, He C, Chen H.
europepmc   +2 more sources

Use of carefully titrated ultra‐low doses of alteplase in infected haemothorax caused by initial alteplase use to drain loculated malignant pleural effusion

Respirology Case Reports, 2023
Alteplase as a fibrinolytic can be used to break up fibrin to encourage clot breakdown for clinical use. In the pleural space, it is used for symptomatic loculated malignant pleural effusions and pleural infections and can potentially avoid the need for ...
Jeong Suk Oh, Chris Yoo, Donny Wong
doaj   +1 more source

Economic evaluation of endovascular treatment for acute ischaemic stroke in Thailand

BMJ Open, 2022
Objectives Endovascular therapy (EVT) has proven to be clinically effective in treating large vessel occlusion acute ischaemic stroke (AIS), either alone or in combination with intravenous alteplase.
Yot Teerawattananon, Wanrudee Isaranuwatchai, Waranya Rattanavipapong, Yongchai Nilanont, Thanaboon Worakijthamrongchai, Budsadee Soboon, Vilawan Luankongsomchit, Mananchaya Kongmuangpuk   +7 more
doaj   +1 more source

Transcranial Histotripsy Clot and Tissue Ablation for Intracerebral Hemorrhage Evacuation and Other Brain Applications

, 2023
STROKE: Vascular and Interventional Neurology, EarlyView.
Jonathan Sukovich, Zhen Xu, Aditya S. Pandey   +2 more
wiley   +1 more source

Clinical efficacy and safety analysis of argatroban and alteplase treatment regimens for acute cerebral infarction

Journal of Neurorestoratology, 2022
ObjectiveThis study compared the clinical efficacy and safety of argatroban and alteplase in the treatment of acute cerebral infarction.MethodsThis study retrospectively analyzed 131 patients admitted for acute cerebral infarction within 48 h of onset ...
Lifang Xu, Xiaofeng Yang, He Gao, Xin Wang, Bo Zhou, Yan Li, Lin Li, Xiaoling Guo, Liqun Ren   +8 more
doaj   +1 more source

Outcomes of Endovascular Thrombectomy with and without Thrombolysis for Acute Large Artery Ischaemic Stroke at a Tertiary Stroke Centre

Cerebrovascular Diseases Extra, 2017
Background and Purpose: Endovascular thrombectomy (EVT) improves the functional outcome when added to best medical therapy, including alteplase, in patients with acute ischaemic stroke secondary to large vessel occlusion (LVO) in the anterior circulation.
Chee-Keong Wee, William McAuliffe, Constantine C. Phatouros, Timothy J. Phillips, David Blacker, Tejinder P. Singh, Ellen Baker, Graeme J. Hankey   +7 more
doaj   +1 more source

Effect of alteplase on platelet function and receptor expression

Journal of International Medical Research, 2019
Objective To investigate the role of alteplase, a widely-used thrombolytic drug, in platelet function. Methods Human platelets were incubated with different concentrations of alteplase followed by analysis of platelet aggregation in response to adenosine
Jun Lu, Peng Hu, Guangyu Wei, Qi Luo, Jianlin Qiao, Deqin Geng   +5 more
doaj   +1 more source

Effect of Intravenous Thrombolytic Dose of Alteplase on Long-Term Prognosis in Patients with Acute Ischemic Stroke

Neurology and Therapy, 2023
Introduction This study aimed to investigate the long-term prognostic effects of different alteplase doses on patients with acute ischemic stroke (AIS). Methods In this cohort study, we enrolled 501 patients with AIS treated with intravenous thrombolysis
Mingfeng Zhai, Shugang Cao, Jinwei Yang, Xiaoyan Cao, Zhong Dong, Wanyin Liu, Yongzhan Fu, Qiyue Guan, Yu Wang, Hongbo Liu   +9 more
doaj   +1 more source

Minor Non-Disabling Stroke Patients with Large Vessel Severe Stenosis or Occlusion Might Benefit from Thrombolysis

Brain Sciences, 2021
Background: The benefit of alteplase in minor non-disabling acute ischemic stroke (AIS) is unknown. We aimed to explore the clinical efficacy of alteplase-treatment in minor non-disabling stroke in clinical practice.
Wansi Zhong, Ying Zhou, Kemeng Zhang, Shenqiang Yan, Jianzhong Sun, Min Lou   +5 more
doaj   +1 more source