Anticoagulation Strategies in Adults Undergoing Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis. [PDF]
In this meta‐analysis of 2 775 adult ECMO patients from non‐randomized studies, direct thrombin inhibitors and low‐molecular‐weight heparins demonstrated a favorable efficacy and safety profile over unfractionated heparin. These findings suggest them to be effective alternatives to unfractionated heparin, underscoring the urgent need for randomized ...
Scharner V +7 more
europepmc +2 more sources
Dual Antiplatelet Therapy in Acute Branch Atheromatous Disease (BAD)-Related Stroke: A Multicenter Propensity-Matched Cohort Analysis. [PDF]
The study aimed to compare the clinical outcomes of dual antiplatelet therapy (DAPT) vs. single antiplatelet therapy (SAPT) in branch atheromatous disease (BAD)‐related stroke. DAPT was safe but not statistically superior to SAPT for excellent functional outcome; however, its numerical trend toward benefit warrants further investigation.
Hu H +10 more
europepmc +2 more sources
Treatment of Heparin-Induced Thrombocytopenia in the Setting of Venoarterial Extracorporeal Membrane Oxygenation as a Bridge to Orthotopic Heart Transplant. [PDF]
Heparin‐induced thrombocytopenia (HIT) is a highly impactful prothrombotic condition produced by antibody formation after heparin administration, which leads to platelet activation and both thrombocytopenia and paradoxical thrombosis. HIT has a relatively high mortality rate and greatly complicates anticoagulation strategy in patients requiring ...
Han EJ, Kalekas N, Vandiver MS.
europepmc +2 more sources
Resolving Bivalirudin Interference on Fibrinogen Testing by the Use of Activated Carbon. [PDF]
The influences of bivalirudin on fibrinogen assays differ considerably. Activated carbon can effectively remove bivalirudin from plasma, thereby eliminating its interference in fibrinogen detection. ABSTRACT Background Direct thrombin inhibitors may lead to falsely low fibrinogen results.
Du J +5 more
europepmc +2 more sources
POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management
ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley +1 more source
A Case of Recurrent Acute Myocardial Infarction Complicated With Idiopathic Thrombocytopenic Purpura
ABSTRACT Managing patients with immune thrombocytopenic purpura (ITP) and thrombocytopenia is challenging when they present with AMI, especially when platelets are severely decreased after interventional therapy. Our case shows that such patients, if stable, can be safely and successfully treated with glucocorticoid to improve platelet count after ...
Chengping Hu, Xuhe Gong
wiley +1 more source
Abstract Background The cerebellum has traditionally been regarded as a structure primarily involved in motor coordination. However, accumulating evidence indicates that the cerebellum can exert substantial influence on cognitive and emotional processes.
Daisuke Yoshioka +2 more
wiley +1 more source
Bioresorbable Scaffolds for Coronary Arteries: Where Do We Stand Today?
Bioresorbable coronary scaffolds are moving from thick strut pitfalls to thinner, stronger, healing‐oriented designs. Integrating advances in materials, guided implantation with preparation, size, and postdilation steps, and resorption aligned to healing, we synthesize clinical evidence and chart a roadmap toward intelligent, transient platforms ...
Junya Matsuda +5 more
wiley +1 more source
Hierarchical clustering of viscoelastic and conventional coagulation parameters identified three distinct phenotypes in V‐V ECMO patients, revealing substantial APTT–CK‐R discordance and highlighting the value of TEG‐derived markers for detecting coagulopathy not captured by standard monitoring.
Daisuke Irimada +9 more
wiley +1 more source
Unlike deceased‐donor liver transplantation, living‐donor liver transplantation (LDLT) for Budd‐Chiari Syndrome (BCS) presents distinctive challenges in hepatic venous (HV)‐outflow reconstruction because diseased HV–inferior vena cava (IVC) cannot be entirely replaced with healthy donor vessels.
Koichiro Hata +4 more
wiley +1 more source

