Results 41 to 50 of about 9,938 (160)

Intravenous Thrombolysis Combined With Endovascular Treatment Versus Endovascular Treatment Alone in Acute Ischemic Stroke due to Tandem Lesions: A Systematic Review and Meta‐Analysis

Brain and Behavior, Volume 16, Issue 8, August 2026.
Our systematic review and meta‐analysis evaluate whether intravenous thrombolysis (IVT) plus endovascular therapy (EVT) outperforms EVT alone in patients with acute ischemic stroke due to tandem lesions. Pooled data from nine studies involving 1756 patients demonstrate that IVT + EVT is associated with significantly higher rates of functional ...
Wenqian Wei, Chongxu Zhong, Jian Tang, Liufei Chen, Kunlong Yao, Liyong Li, Shengliang Shi, Yueling Zhang, Jian Zhang   +8 more
wiley   +1 more source

Interventional Mechanical Thrombectomy for Limb Salvage in Rapidly Progressive Phlegmasia Cerulea Dolens

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Mechanical thrombectomy can provide rapid, fibrinolysis‐free restoration of venous flow in phlegmasia cerulea dolens. This case highlights an unusually severe course with extensive iliofemorocaval thrombosis, rhabdomyolysis, MRI‐confirmed muscle necrosis, and arterial hypoperfusion despite anticoagulation, in which urgent intervention achieved
Johan Filo, Manuel Stern, Malte Kelm, Lucas Busch, Patricia Wischmann   +4 more
wiley   +1 more source

Efficacy of argatroban plus alteplase according to time from onset to thrombolysis in acute ischemic stroke: a prespecified post-hoc analysis of the ARAIS trial

Frontiers in Neurology
BackgroundThe Argatroban Plus Recombinant Tissue-Type Plasminogen Activator for AIS (ARAIS) trial failed to demonstrate the benefit of argatroban in patients diagnosed with acute ischemic stroke who were treated with intravenous alteplase.
Yu Cui, Er-Qiang Wang, Yi-Han Wang, Hui-Sheng Chen   +3 more
doaj   +1 more source

Optimising hyperacute intracerebral haemorrhage management: factors influencing timely intervention

Internal Medicine Journal, Volume 56, Issue 8, Page 1394-1401, August 2026.
Abstract Background Bundled‐care protocols, which include rapid lowering of blood pressure, have improved functional outcomes in patients with intracranial haemorrhage (ICH). Specifically, the intensive blood pressure reduction in acute cerebral hemmorhage trail (INTERACT) 3 trial aimed to achieve rapid lowering of systolic blood pressure (SBP) to 140 ...
Edmund Proper, Thanh Phan, Henry Ma, Michael Valente   +3 more
wiley   +1 more source

Outcome of Treatment with Intravenous Alteplase in Acute Stroke Patients [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2023
Background and Objective: Stroke is one of the main causes of death and disability in the world, and its treatment includes the re-supply of blood to the brain tissue using different methods, including alteplase injection.
H Nemati, P Saadat, A Ahmadi Ahangar, V Nematian, S Alijanpour, A Bijani   +5 more
doaj  

Nonlinear Association Between the C‐Reactive Protein‐To‐Albumin Ratio and Post‐Stroke Epilepsy Risk

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
The C‐reactive protein‐to‐albumin ratio (CAR) is a robust, independent predictor of post‐stroke epilepsy (PSE) in ischemic stroke patients, exhibiting a nonlinear, threshold‐dependent association. As an integrative biomarker, CAR holds promise for enhancing early risk stratification and informing personalized intervention strategies.
Xiao Wu, Yingru Zhou, Qi Yang, Yunliang Tang   +3 more
wiley   +1 more source

Consensus Recommendations for Clinical Pharmacist Integration into the Acute Stroke Care Team: Endorsed by the American College of Clinical Pharmacy, Neurocritical Care Society, Society for Academic Emergency Medicine, and Society of Critical Care Medicine, and affirmed by the American Academy of Neurology

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 7, July 2026.
Graphical abstract of consensus recommendations for clinical pharmacist integration into the acute stroke care team. ABSTRACT Clinical pharmacists are increasingly recognized as vital contributors to acute stroke care, yet their role remains inconsistently defined and underutilized across health care systems.
Brian W. Gilbert, Caitlin S. Brown, Nicole M. Acquisto, Kellyn K. Engstrom, Kevin J. Mercer, Gavin T. Howington, David E. Zimmerman, Michael Gottlieb, Alicia E. Mattson, Megan A. Rech, Erin D. Wieruszewski, Andrew J. Webb, Brett Faine, Lance C. Ray, Kent A. Owusu, Barbara Voetsch, Dana Gerberi, Kristin Cole, Fernanda Bellolio   +18 more
wiley   +1 more source

Effects of alteplase in the treatment of acute ischemic stroke

International Journal of General Medicine, 2012
Josef YayanDepartment of Internal Medicine, Vinzentius Hospital, Landau, GermanyBackground: For the last 15 years, alteplase (recombinant tissue plasminogen activator) has been used widely throughout the world for the treatment of acute ischemic stroke ...
Yayan J
doaj  

Direct Thrombectomy vs. Combined Treatment With Intravenous Thrombolysis in the Extended Time Window: A Target Trial Emulation

European Journal of Neurology, Volume 33, Issue 7, July 2026.
This target‐trial emulation compared direct MT (n = 212) vs. IVT + MT (n = 135) in anterior‐circulation LVO patients treated 4.5–24 h or at wake‐up, eligible for IVT with perfusion mismatch. Using IPW with a non‐inferiority margin RD ≥ −1.3% for 90‐day mRS 0–2, direct MT was not non‐inferior to IVT + MT (adjRD −2.9%, 95% CI −6.64 to 0.84).
Ettore Nicolini, Antonio Ciacciarelli, Giovanni Pracucci, Valentina Saia, Luigi Simonetti, Andrea Zini, Valerio Da Ros, Federica D'agostino, Marta Iacobucci, Manuela De Michele, Marco Andrighetti, Rossana Tassi, Andra Saletti, Ilaria Casetta, Enrico Fainardi, Alfredo Pauciulo, Marcella Caggiula, Roberto Menozzi, Alessandro Pezzini, Stefano Vallone, Guido Bigliardi, Domenico Sergio Zimatore, Marco Petruzzellis, Alessio Comai, Enrica Franchini, Luca Allegretti, Tiziana Tassinari, Nicola Limbucci, Patrizia Nencini, Giuseppe Carità, Monia Russo, Marco Filizzolo, Marina Mannino, Maria Ruggiero, Marco Longoni, Andrea Boghi, Andrea Naldi, Mauro Bergui, Giovanni Bosco, Giuseppe Pelle, Michele Alessiani, Matteo Alberti, Paolo Invernizzi, Raffaele Augelli, Manuel Cappellari, Guido Andrea Lazzarotti, Nicola Giannini, Daniel Konda, Fabrizio Sallustio, Salvatore Mangiafico, Danilo Toni, on behalf of the IRETAS group   +51 more
wiley   +1 more source

Intrapleural fibrinolytic therapy with alteplase in empyema thoracis in children - A prospective pilot study

Journal of Pediatric Critical Care, 2014
Objective:outcome of children treated with Intrapleural alteplase therapy in empyema thoracis Design: Prospective interventional pilot study Setting:Pediatric Critical care and Pulmonology unit at Tertiary care Hospital Subjects: All patients of empyema ...
P K Sharma, B Saikia, R Sharma, P Jain, Z Hussain, P Khilnani   +5 more
doaj   +1 more source