Response by Bivard et al to letter regarding article, "Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke: Analysis of 2 Randomized Controlled Trials" [PDF]
, 2017 No abstract ...
Bivard, Andrew +2 more
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Comparison of predictive scores of symptomatic intracerebral haemorrhage after stroke thrombolysis in a single centre [PDF]
, 2015 Peer reviewedPublisher ...
Dai, D. +3 more
core +1 more source
Effectiveness of Standard-Dose vs. Low-Dose Alteplase for Acute Ischemic Stroke Within 3–4.5 h
Frontiers in Neurology, 2022 BackgroundThe efficacy and safety of intravenous alteplase administered 3–4.5 h after acute ischemic stroke have been demonstrated. However, whether responses differ between low-dose and standard-dose alteplase during this time window and whether certain
Chih-Hao Chen +18 more
doaj +1 more source
Neuroimaging as a selection tool and endpoint in preclinical and clinical trials [PDF]
, 2016 Standard imaging in acute stroke enables the exclusion of non-stroke structural CNS lesions and cerebral haemorrhage from clinical and pre-clinical ischaemic stroke trials. In this review, the potential benefit of imaging (e.g., angiography and penumbral
Macrae, I. Mhairi, Muir, Keith W.
core +2 more sources
Development of a decision analytic model to support decision making and risk communication about thrombolytic treatment [PDF]
, 2015 Background Individualised prediction of outcomes can support clinical and shared decision making. This paper describes the building of such a model to predict outcomes with and without intravenous thrombolysis treatment following ischaemic stroke ...
A Bannat +7 more
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Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR) [PDF]
, 2009 <p><b>Background and Purpose:</b> The optimal management of blood pressure (BP) in acute stroke remains unclear. For ischemic stroke treated with intravenous thrombolysis, current guidelines suggest pharmacological intervention if ...
Ahmed, N. +4 more
core +1 more source
The association of neutrophil-lymphocyte ratio and lymphocyte-monocyte ratio with 3-month clinical outcome after mechanical thrombectomy following stroke [PDF]
, 2020 Background and aim Neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR) are associated with clinical outcomes in malignancy, cardiovascular disease and stroke.
Alakbarzade, V +7 more
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Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST) [PDF]
, 2008 <p><b>Background and Purpose:</b> The Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST) unadjusted results demonstrated that intravenous alteplase is well tolerated and that the effects were comparable with ...
Ahmed, Niaz +19 more
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Dose de-escalation of intrapleural tissue plasminogen activator therapy for pleural infection. The alteplase dose assessment for Pleural infection Therapy project [PDF]
, 2017 Rationale: Intrapleural therapy with a combination of tissue plasminogen activator (tPA) 10 mg and DNase 5 mg administered twice daily has been shown in randomized and open-label studies to successfully manage over 90% of patients with pleural infection ...
Bintcliffe, Oliver +10 more
core +1 more source
Trials, 2022 Background The effectiveness of alteplase for ischemic stroke treatment is limited, partly due to the occurrence of intracranial and extracranial hemorrhage. Mutant pro-urokinase (m-proUK) does not deplete fibrinogen and lyses fibrin only after induction
Nadinda A. M. van der Ende +17 more
doaj +1 more source