Results 71 to 80 of about 28,483 (297)

Safety and Efficacy of Dual Thrombolytic Therapy With Mutant Prourokinase and Small Bolus Alteplase for Ischemic Stroke: A Randomized Clinical Trial.

JAMA Neurology, 2023
Importance Dual thrombolytic treatment with small bolus alteplase and mutant prourokinase has the potential to be a safer and more efficacious treatment for ischemic stroke than alteplase alone because mutant prourokinase is designed to act only on ...
N. V. D. van der Ende, B. Roozenbeek, Lucas Smagge, Sven P. R. Luijten, L. Aerden, Petra Kraayeveld, I. R. van den Wijngaard, G. J. Lycklama à Nijeholt, H. D. den Hertog, H. Z. Flach, A. Postma, S. Roosendaal, G. M. Krietemeijer, Lonneke S. F. Yo, M. D. de Maat, D. Nieboer, G. D. del Zoppo, W. Meurer, Hester F. Lingsma, A. van der Lugt, D. Dippel   +20 more
semanticscholar   +1 more source

Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research. [PDF]

, 2017
Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size.
Akyol, Onat, Applegate, Richard, Araujo, Camila, Ho, Wing Mann, Huang, Lei, Reis, Cesar, Zhang, John H   +6 more
core   +3 more sources

Abstract Number ‐ 259: Recanalization Before Completion of Alteplase Infusion Leads to Improved Outcomes: A Retrospective Analysis

Stroke: Vascular and Interventional Neurology, 2023
Introduction The recently published CHOICE trial found that intra‐arterial infusion of alteplase improved clinical outcomes in patients undergoing EVT for LVO AIS, an effect that was possibly due to a reduction in reperfusion‐related injury.
Ivo Bach, Alexandra L Czap, Deepa Dongarwar, Sunil A Sheth   +3 more
doaj   +1 more source

Tenecteplase versus alteplase for acute ischaemic stroke: a meta-analysis of phase III randomised trials

Stroke and vascular neurology, 2023
Background Tenecteplase (TNK) was found non-inferior to alteplase in recent clinical trials. We aimed to elucidate the efficacy and safety of TNK versus alteplase for acute ischaemic stroke (AIS).
Yunyun Xiong, Liyuan Wang, Guangshuo Li, Kaixuan Yang, M. Hao, Shuya Li, Yuesong Pan, Yongjun Wang   +7 more
semanticscholar   +1 more source

NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II trials [PDF]

, 2008
<p><b>Background and Purpose:</b> In animal models of acute ischemic stroke (AIS), the free radical-trapping agent NXY-059 showed promise as a neuroprotectant.
Alderfer, V., Ashwood, T., Davalos, A., Davis, S.M., Diener, H.C., Grotta, J., Hardemark, H.G., Lees, K.R., Lyden, P., Rodichok, L., Shuaib, A., Wasiewski, W.   +11 more
core   +1 more source

Low-dose vs. standard-dose intravenous alteplase for acute ischemic stroke with unknown time of onset

Frontiers in Neurology, 2023
BackgroundStandard-dose intravenous alteplase for acute ischemic stroke (AIS) in the unknown or extended time window beyond 4.5 h after symptom onset is both effective and safe for certain patients who were selected based on multimodal neuroimaging ...
Zekun Wang, Kangxiang Ji, Qi Fang
doaj   +1 more source

Response by Bivard et al to letter regarding article, "Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke: Analysis of 2 Randomized Controlled Trials" [PDF]

, 2017
No abstract ...
Bivard, Andrew, Muir, Keith, Parsons, Mark   +2 more
core   +1 more source

Fatal Outcome of Intravenous Thrombolysis With an Unexpected Finding of Amyloid‐β‐Related Angiitis—A Case Report Highlighting a Relevant Scenario With Acute Focal Neurological Deficits and Minimal Radiological Presentation

Neuropathology, EarlyView.
ABSTRACT Cerebral amyloid angiopathy (CAA) has been implicated as a risk for developing lobar intracerebral hemorrhage (ICH) after intravenous thrombolysis (IVT) applied for acute ischemic stroke (AIS). However, there is a paucity of cases reported with histopathological CAA diagnosis in this setting, with a single report to imply the role of CAA ...
Kristof Babarczy, Bence L. Radics, Orsolya Horvath, Peter Klivenyi, Levente Szalardy   +4 more
wiley   +1 more source

Comprehensive Review of Tenecteplase for Thrombolysis in Acute Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Although intravenous thrombolysis with alteplase remains the primary treatment for acute ischemic stroke, tenecteplase has shown potential advantages over alteplase.
Liyuan Wang, Manjun Hao, Na Wu, Shuangzhe Wu, Marc Fisher, Yunyun Xiong   +5 more
doaj   +1 more source

Evidence of Anaphylaxy After Alteplase Infusion [PDF]

Stroke, 1999
Background and Purpose —Although alteplase, a recombinant tissue plasminogen activator (tPA), is structurally identical to endogenous tPA and therefore should not induce allergy, single cases of acute hypersensitivity reactions have been reported.
William S. Prince, Wolf-Dieter Heiss, Jobst Rudolf, Susanne Schmülling, M. Grond   +4 more
openaire   +2 more sources