Results 71 to 80 of about 12,417 (199)

Inflammatory Markers Mediate the Prognosis of Baseline Mismatch Volume and 90‐Day Outcomes in Acute Ischemic Stroke Patients

Brain and Behavior, Volume 16, Issue 1, January 2026.
AIS prognosis is not solely determined by baseline mismatch volume but is also significantly influenced by systemic inflammatory responses. Larger baseline mismatch volume, higher NLR and MLR, and lower PNR were significantly associated with poor outcomes in patients with 90‐day AIS.
Lianhong Ji, Xinyu Xu, Peian Liu, Li Li, Jiale Gan, Junqi Liao, Yongxing Deng, Hui Jiang, Yunfei Han, Wenlei Li, Yuan Zhu, Minghua Wu   +11 more
wiley   +1 more source

Association Between Intraventricular Alteplase Use and Parenchymal Hematoma Volume in Patients With Spontaneous Intracerebral Hemorrhage and Intraventricular Hemorrhage [PDF]

, 2021
Jens Witsch, David Roh, Radhika Avadhani, Alexander E. Merkler, Hooman Kamel, Issam A. Awad, Daniel F. Hanley, Wendy Ziai, Santosh B. Murthy   +8 more
openalex   +1 more source

Percutaneous Reperfusion Therapies vs. Anticoagulation in Patients With Acute Intermediate‐High‐Risk Pulmonary Embolism: The PRETHA Randomized Clinical Trial

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT The optimal treatment strategy for patients with acute intermediate–high‐risk pulmonary embolism (PE) remains uncertain. This randomized clinical trial (PRETHA) aimed to evaluate the efficacy and safety of percutaneous reperfusion therapies—trans‐catheter thrombectomy and trans‐catheter thrombolysis—compared with standard anticoagulation ...
Taida Ivanauskienė, Andrius Berūkštis, Greta Burneikaitė, Aurelija Daubaraitė, Kastė Ivanauskaitė, Mindaugas Matačiūnas, Giedrius Navickas, Rasa Kūgienė, Marcin Kurzyna, Sigita Glaveckaitė   +9 more
wiley   +1 more source

Eficacia y seguridad del tenecteplase en el tratamiento del ACV isquémico agudo

Acta Neurológica Colombiana, 2020
El alteplase es el único fibrinolítico actualmente autorizado en Colombia para el tratamiento del ACV isquémico agudo. El tenecteplase constituye una nueva alternativa de tratamiento en esta enfermedad al ofrecer mejor perfil farmacológico, mayor ...
Javier Francisco Torres Zafra, Germán Enrique Pérrez Romero   +1 more
doaj   +1 more source

Challenges in Managing Cerebral Amyloid Angiopathy in Alzheimer's Disease: Insights from a Case of Down Syndrome‐associated Alzheimer Disease (DSAD)

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Cerebral amyloid angiopathy (CAA) is more frequently found in Down syndrome associated Alzheimer's disease (DSAD) than in sporadic forms of Alzheimer's disease (AD). Although the pathophysiological process starts before, in Down syndrome (DS), neuroimaging features of CAA can be detected from the early 30s and progress with age. CAA
Lucía Maure‐Blesa, Maria Borrell Pichot, Íñigo Rodríguez‐Baz, Patricia Carbonell Fernández, Javier Arranz, José Enrique Arriola‐Infante, Mateus Rozalem Aranha, Alexandre Bejanin, Isabel Barroeta, Juan Fortea, Pol Camps‐Renom, Maria Carmona‐Iragui   +11 more
wiley   +1 more source

Intravenous tenecteplase compared with alteplase for minor ischaemic stroke: a secondary analysis of the AcT randomised clinical trial

Stroke and Vascular Neurology
Background In ischaemic stroke, minor deficits (National Institutes of Health Stroke Scale (NIHSS) ≤5) at presentation are common but often progress, leaving patients with significant disability.
Dar Dowlatshahi, Mohammed A Almekhlafi, Tolulope Sajobi, Aleksandra Pikula, Ashfaq Shuaib, Alexandre Y Poppe, Richard H Swartz, Fouzi Bala, Ibrahim Alhabli, Aleksander Tkach, Heather Williams, Shelagh B Coutts, Nishita Singh, Anurag Trivedi, Andrew Demchuk, Gary Hunter, Brian H Buck, Faysal Benali, Bijoy Menon, MacKenzie Horn, Radhika Nair, Thalia Field, Mahesh Kate, Negar Asdaghi, Robert Sarmiento, Ayoola Ademola, Houman Khosravani, Herbert Alejandro Manosalva Alzate, Luciana Catanese   +28 more
doaj   +1 more source

Predictors of the unfavorable outcomes in acute ischemic stroke patients treated with alteplase, a multi-center randomized trial

Scientific Reports
Worldwide, stroke is a leading cause of long-term disability in adults. Alteplase is the only approved treatment for acute ischemic stroke (AIS) and results in an improvement in a third of treated patients.
Mohamed G. Zeinhom, Mohamed Fouad Elsayed Khalil, Islam Fathallah Mohamed Kamel, Ahmed Mohamed Kohail, Sherihan Rezk Ahmed, Ahmed Elbassiouny, Ashfaq Shuaib, Omar M Al-Nozha   +7 more
doaj   +1 more source

Tenecteplase in Ischemic Stroke: Challenge and Opportunity

Neuropsychiatric Disease and Treatment, 2022
Guangshuo Li,1 Chuanying Wang,1 Shang Wang,1,2 Yunyun Xiong,1– 3,* Xingquan Zhao1,2,* 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2China National Clinical Research Center ...
Li G, Wang C, Wang S, Xiong Y, Zhao X
doaj  

Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke

, 2023
Dawei Chen, Yu Cui, Zhonghe Zhou, Hong Zhang, Lixia Wang, Weizhong Wang, Liying Shen, Liyan Guo, Er-Qiang Wang, Ruixian Wang, Jing Han, Yu-Ling Dong, Jing Li, Yongzhong Lin, Qingcheng Yang, Li Zhang, Jingyu Li, Jin Wang, L. Xia, Guang-Bin Ma, Jiang Lu, Changhao Jiang, Shuman Huang, Li-Shu Wan, Hulin Piao, Zhuo Li, Yansong Li, Kui-Hua Yang, Duolao Wang, Thanh N. Nguyen, Zhuo Gao, Hang Zhao, Xiaodong Liu, Xuewen Liu, Lihong Zhang, Ling Zhang, Li Li, Jia-Dong Zhang, Xinqiang Wang, Wenhai Yang, Shi-Mei Geng, Lian-Qiang Wang, Run-Hui Li, Run-Hui Li   +43 more
openalex   +2 more sources

Alteplase in COVID-19 severe hypoxemic respiratory failure: the TRISTARDS multicenter randomized trial

Annals of Intensive Care
Background Pulmonary intravascular thrombus formation has been widely observed in patients with respiratory failure, for example, in patients with SARS-CoV-2 infection (COVID-19).
Giovanni Landoni, Pratima Chowdary, Ferhat Meziani, Jacques Creteur, Nicolas De Schryver, Johann Motsch, Ingrid Henrichmoeller, Alain Pagès, Nuala Peter, Thierry Danays, Markus A. Weigand, the TRISTARDS Investigators   +11 more
doaj   +1 more source