Results 71 to 80 of about 20,386 (204)

Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management

MedComm, Volume 7, Issue 4, April 2026.
Within minutes after ischemia onset, deprivation of oxygen and glucose leads to rapid ATP depletion, resulting in failure of Na+/K+‐ATPase activity and membrane depolarization. This ionic imbalance promotes uncontrolled synaptic release of glutamate and excessive activation of postsynaptic NMDA and AMPA receptors.
Meibiao Zhang, Jianxun Hou, Jia Kuang, Lei Hao, Zhao Yang   +4 more
wiley   +1 more source

Statistical analysis of the primary outcome in acute stroke trials [PDF]

, 2012
Common outcome scales in acute stroke trials are ordered categorical or pseudocontinuous in structure but most have been analyzed as binary measures. The use of fixed dichotomous analysis of ordered categorical outcomes after stroke (such as the modified
Altman, H., Bath, P.M.W., Bland, M., Hogg, C., Howard, G., Lees, K.R., Saver, J.L., Schellinger, P.D.   +7 more
core   +1 more source

From Innovation to Validation: Strengthening Interventional Radiology Through Data

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Kaiwen Cabbabe, Gerard S. Goh, Charles Li, Matthew Lukies   +3 more
wiley   +1 more source

A Parallel Group, 1:1 Randomised, Pilot Study Comparing the Clinical Efficacy and Bleeding Risk Between Low Dose and Standard Dose Intrapleural Tissue Plasminogen Activator for Adults With Pleural Infection

Respirology Case Reports, Volume 14, Issue 4, April 2026.
This protocol is for the TRAPPE study, a pilot study to serve as preparatory work before proceeding to a full‐scale, multicentre RCT. The feasibility of the study design involving flexibility of dose escalation and various clinical parameters will be tested for suitability as study outcome measurements before proceeding to a full‐scale RCT.
Ken Ka Pang Chan, Christopher Chan, David Shu Cheong Hui, Ai Ling Tan, Y. C. Gary Lee   +4 more
wiley   +1 more source

Effects of alteplase in the treatment of acute ischemic stroke

International Journal of General Medicine, 2012
Josef YayanDepartment of Internal Medicine, Vinzentius Hospital, Landau, GermanyBackground: For the last 15 years, alteplase (recombinant tissue plasminogen activator) has been used widely throughout the world for the treatment of acute ischemic stroke ...
Yayan J
doaj  

Resolution of Occlusive Carotid Artery Thrombus Treated with Anticoagulation as Demonstrated on Duplex Ultrasonography. [PDF]

, 2017
BACKGROUND AND PURPOSE: While the majority of cerebral ischemic events due to carotid occlusive disease result from atherosclerotic plaque rupture, intraluminal carotid artery thrombus occasionally occurs in patients without preexisting carotid ...
Liang, John W., Stein, Laura, Weinberger, Jesse   +2 more
core   +2 more sources

Basilar Artery Occlusion Stroke Managed With Tenecteplase Versus Alteplase Before Endovascular Treatment (BAO‐TNK)

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 574-580, March 2026.
ABSTRACT Objective To compare the effectiveness and safety of tenecteplase (TNK) versus alteplase (TPA) in patients with basilar artery occlusion prior to endovascular treatment (EVT). Methods In this retrospective multicenter study (BAO‐TNK), we analyzed consecutive BAO patients from 14 U.S.
Rahul R. Karamchandani, Dylan N. Wolman, Tyler M. Bielinski, Nitin Goyal, Jeremy B. Rhoten, Mahesh V. Jayaraman, Christian T. Sidebottom, Bradley A. Gross, Alhamza R. Al‐Bayati, Mohamed F. Doheim, Matthew K. Tobin, Anoop Chinthala, Avi Gajjar, Justin Mascitelli, Matthew R. Webb, Jan‐Karl Burkhardt, Kyle W. Scott, Visish Srinivasan, Daniel Tonetti, Manisha Koneru, David J. Altschul, Dhrumhil Vaishnav, Sumeet Multani, Thana Theofanis, William J. Ares, Je Yeong Sone, Ramin Zand, Sasan Bahrami, Jiang Li, Gary Defilipp, Dale Strong, Radmehr Torabi, Krisztina Moldovan, Kelsey E. Kline, Clemens M. Schirmer, Raul G. Nogueira, Alexandra R. Paul, Bradley N. Bohnstedt, Philipp Hendrix   +38 more
wiley   +1 more source

Intrapleural fibrinolytic therapy with alteplase in empyema thoracis in children - A prospective pilot study

Journal of Pediatric Critical Care, 2014
Objective:outcome of children treated with Intrapleural alteplase therapy in empyema thoracis Design: Prospective interventional pilot study Setting:Pediatric Critical care and Pulmonology unit at Tertiary care Hospital Subjects: All patients of empyema ...
P K Sharma, B Saikia, R Sharma, P Jain, Z Hussain, P Khilnani   +5 more
doaj   +1 more source

Tenecteplase Versus Alteplase for First‐Pass Reperfusion in Basilar Artery Occlusion Stroke Thrombectomy

Annals of Neurology, Volume 99, Issue 3, Page 692-704, March 2026.
Objective The first‐pass effect (FPE), defined as excellent reperfusion after a single attempt, is associated with improved outcomes in large vessel occlusion stroke. We evaluated whether intravenous tenecteplase (TNK) compared with alteplase (TPA) increases the likelihood of FPE in basilar artery occlusion (BAO).
Dylan N. Wolman, Rahul R. Karamchandani, Sina Hemmer, Tyler M. Bielinski, Nitin Goyal, Jeremy B. Rhoten, Mahesh V. Jayaraman, Christian T. Sidebottom, Bradley A. Gross, Alhamza R. Al‐Bayati, Mohamed F. Doheim, Matthew K. Tobin, Anoop Chinthala, Avi Gajjar, Justin Mascitelli, Matthew R. Webb, Jan‐Karl Burkhardt, Kyle W. Scott, Visish Srinivasan, Daniel Tonetti, Manisha Koneru, David J. Altschul, Dhrumhil Vaishnav, Sumeet Multani, Thana Theofanis, William J. Ares, Je Yeong Sone, Ramin Zand, Sasan Bahrami, Jiang Li, Gary Defilipp, Dale Strong, Radmehr Torabi, Krisztina Moldovan, Clemens M. Schirmer, Alexandra R. Paul, Bradley N. Bohnstedt, Raul G. Nogueira, Philipp Hendrix   +38 more
wiley   +1 more source

No relation between body temperature and arterial recanalization at three days in patients with acute ischaemic stroke [PDF]

, 2015
Background: Recanalization of an occluded intracranial artery is influenced by temperature-dependent enzymes, including alteplase. We assessed the relation between body temperature on admission and recanalization.
Bakker, S.L.M. (Stef), Bienfait, H.P. (Henri), Biessels, G.J., Biessels, G.J. (Geert Jan), Boiten, J. (Jelis), Bot, J. (Joseph), Dankbaar, J.W. (Jan), Dijk, E.J. (Ewoud) van, Dippel, D.W.J. (Diederik), Droogh-De Greve, K.E., Duijm, L.E.M. (Lucien), Duyndam, A. (Anita), Geurts, M. (Marjolein), Graaf, Y. (Yolanda) van der, Hofmeijer, J., Horsch, A.D. (Alexander D.), Horsch, A.D. (Alexander D.), Kappelle, L.J., Kappelle, L.J. (Jaap), Keizer, K. (Koos), Kesselring, A.M. (Anouk), Kort, P.L.M. (Paul) de, Kwa, V.I.H., Lugt, A. (Aad) van der, Luitse, J.S.K., Lycklama à Nijeholt, G.J. (Geert), Majoie, C.B. (Charles), Mali, W.P. (Willem), Meijer, F.J. (F.), Niesten, J.M. (Joris), Pleiter, C.C. (C.), Rooij, W.J. (W.) van, Roos, Y.B.W.E.M. (Yvo), Schaaf, I.C. (Irene) van der, Schonewille, W.J. (Wouter), Seeters, T. (Tom) van, Velthuis, B.K. (Birgitta), Visser, M.C. (Marieke), Vos, J.A. (Jan Albert), Walderveen, M.A.A. (Marianne) van, Wermer, M.J.H. (Marieke), Worp, H.B. (Bart) van der   +41 more
core   +1 more source