Results 51 to 60 of about 13,155 (313)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Análise das concepções astronômicas apresentadas por professores de algumas escolas estaduais

Revista Brasileira de Ensino de Física
Muitos professores da Educação Básica (EB) não abordam conceitos relacionados a Astronomia e quando o fazem, seguem livros didáticos os quais muitos contêm erros conceituais, a Astronomia está entre os conteúdos a serem ministrados na EB e faz parte do ...
Edson Pereira Gonzaga, Marcos Rincon Voelzke   +1 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Aproximación al modelo de cueva en la sociedad actual: una revisión de las investigaciones (1998-2018) [PDF]

Ikastorratza.e-Revista de Didáctica, 2019
This article is a revision of the literature (1998-2018) concerning the cave model in current society. Caves are the human entry to the subterranean medium and aquifers in karstic areas supply with water about the 20-25% of world’s population. Literature
Ainara Achurra
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Alternative conceptions about proportional reasoning in high school students

Infinity
This study aimed to identify alternative conceptions about proportional reasoning among High School Students at a public school located in the state of Guerrero, Mexico. Using a qualitative approach, data were collected through task-based interviews with
Hugo Fernando Santana-Ramírez, Gerardo Salgado-Beltrán, Javier García-García, Alejo López-González   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Alternative Conceptions on the Teaching of the Concept of Mass

, 2005
Many studies on misconceptions in physics and in physics teaching have shown that both students and teachers have misconceptions about such important concepts as mass, energy, heat, etc. The author of this communication has made an exhaustive research into conceptions of mass both in the history of Physics and in Physics teaching.
openaire   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source