Results 71 to 80 of about 13,069 (268)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Alternative conceptions of COVID-19 and post-COVID-19 assumed by Basic Education pre-service teachers. A case study for Universidad Técnica del Norte, Ecuador. [PDF]

F1000Res, 2023
Guerra-Reyes F, Naranjo-Toro M, Basantes-Andrade A, Guerra-Dávila E.   +3 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Exploring Secondary Students’ Alternative Conceptions about Engineering Design Technology

Education Sciences, 2019
This paper presents the assessment items that were developed by science and technology teachers in Québec to explore their students’ alternative ideas about engineering design technology and technological systems.
Anila Asghar, Ying-Syuan Huang, Kenneth Elliott, Yannick Skelling   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Concept of Alternative Facts

VAKKI Publications, 2018
Tässä artikkelissa tehdään selkoa vaihtoehtoisen totuuden käsitteestä. Tulokseksi saadaan vaihtoehtoisen totuuden 18 merkitystä, jotka eivät ole toisiaan poissulkevia vaan osittain päällekkäisiä. Tarkastelu perustuu uutisointeihin, jotka koskevat presidentti Donald Trumpin hallinnon synnyttämää mediakeskustelua vaihtoehtoisista totuuksista, totuuden ...
openaire   +5 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Students’ conceptions about energy and the human body [PDF]

Science Education International, 2010
Students’ understanding of energy has been primarily within the domain ofphysics. This study sought to examine students’ understanding of conceptsrelating to energy and the human body using pencil and paperquestionnaires administered to 610 students in ...
David F Treagust, Michael Mann
doaj  

Is the undergraduate microbiology curriculum preparing students for careers in their field?: an assessment of biology majors’ conceptions of growth and control of microorganisms

International Journal of STEM Education, 2018
Background We present an analysis of students’ responses to application-based questions on the topic of growth and control of microorganisms, from a questionnaire administered to 348 second and third year students of an Indian university who were ...
Aakanksha Purushottam Sawant, Swapnaja Arvind Patil, Jyotsna Vijapurkar, Needa Nasir Bagban, Deepti Bhushan Gupta   +4 more
doaj   +1 more source