Results 81 to 90 of about 13,069 (268)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Cogent Social Sciences, 2018 Stimulated by a disjuncture between the expectations and the experiences of conducting research on disability in Zambia, we reflexively reviewed our own research practice to find that it was premised upon an unconscious assumption about the value of ...
Shaun Cleaver, Lilian Magalhães
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Análise das concepções astronômicas apresentadas por professores de algumas escolas estaduais
Revista Brasileira de Ensino de FísicaMuitos professores da Educação Básica (EB) não abordam conceitos relacionados a Astronomia e quando o fazem, seguem livros didáticos os quais muitos contêm erros conceituais, a Astronomia está entre os conteúdos a serem ministrados na EB e faz parte do ...
Edson Pereira Gonzaga +1 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Education SciencesThis exploratory study compares the conceptual performance of human respondents and ChatGPT on the Force Concept Inventory (FCI), a widely used assessment designed to diagnose alternative conceptions in Newtonian mechanics.
Gabriel Dias de Carvalho Junior +3 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Вопросы образованияConsidering the challenges students face in learning physics, exploring the use of peer instruction in primary school could provide teachers with a valuable new teaching strategy. This research encompassed teaching the topics Balance and Energy, with the
Marko Tomik +2 more
doaj +1 more source
Changing University Students’ Alternative Conceptions of Optics by Active Learning
Center for Educational Policy Studies Journal, 2013 Active learning is individual and group participation in effective activities such as in-class observing, writing, experimenting, discussion, solving problems, and talking about to-be-learned topics.
Zalkida Hadžibegović, Josip Sliško
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source