Results 81 to 90 of about 1,598,018 (302)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Quantitative Modeling of the Alternative Pathway of the Complement System. [PDF]

PLoS ONE, 2016
The complement system is an integral part of innate immunity that detects and eliminates invading pathogens through a cascade of reactions. The destructive effects of the complement activation on host cells are inhibited through versatile regulators that
Nehemiah Zewde, Ronald D Gorham, Angel Dorado, Dimitrios Morikis   +3 more
doaj   +1 more source

Tradeoff between short-term and long-term adaptation in a changing environment [PDF]

, 2005
We investigate the competition dynamics of two microbial or viral strains that live in an environment that switches periodically between two states. One of the strains is adapted to the long-term environment, but pays a short-term cost, while the other ...
C. O. Wilke, C. O. Wilke, C. O. Wilke, Claus O. Wilke, E. Domingo, I. S. Novella, J. F. Crow, L. A. Cooper, M. Eigen, M. Kimura, P. E. Turner, Robert Forster, S. C. Weaver   +12 more
core   +2 more sources

Phytopathogens Reprogram Host Alternative mRNA Splicing

Annual Review of Phytopathology
Alternative splicing (AS) is an evolutionarily conserved cellular process in eukaryotes in which multiple messenger RNA (mRNA) transcripts are produced from a single gene. The concept that AS adds to transcriptome complexity and proteome diversity introduces a new perspective for understanding how phytopathogen-induced alterations in host AS cause ...
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Desenvolvimento de Spodoptera eridania (Cramer) (Lepidoptera: Noctuidae) em diferentes hospedeiros

Arquivos do Instituto Biológico
Spodoptera eridania (Cramer) é uma praga em expansão nas culturas, que vem causando prejuízos pela desfolha e pela lesão nas estruturas reprodutivas, o que leva à necessidade de estudos de desenvolvimento em diferentes tipos de hospedeiros. O objetivo do
Flávio Gonçalves de Jesus, Paulo Vinicius de Sousa, Bruna Ribeiro Machado, Alexandre Igor de Azevedo Pereira, Gleina Costa Silva Alves   +4 more
doaj   +1 more source

Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications

Microbiome, 2020
Background Chronic immune-mediated diseases are rapidly expanding and notoriously difficult to cure. Altered relatively stable intestinal microbiota configurations are associated with several of these diseases, and with a possible pre-disease condition ...
Maarten Van de Guchte, Sebastian D. Burz, Julie Cadiou, Jiangbo Wu, Stanislas Mondot, Hervé M. Blottière, Joël Doré   +6 more
doaj   +1 more source

Modes of Foreign Entry under Asymmetric Information about Potential Technology Spillovers [PDF]

, 2002
This paper studies the effect of technology spillovers on the entry decision of a multinational enterprise into a foreign market. Two alternative entry modes for a foreign direct investment are considered: Greenfield investment versus acquisition.
, J.-F Hennar, , J.-Y W Ang, A S Im P Le Mo, B J Ait K En, B K Ogut, B Xu, D Levin, D T C Oe, D T C Oe, E Bor Ensz T Ein, F R Lic Ht Enber G, H G � Or G, H G � Or G, J Benhabib, K E E M Eyer, K Ok K O, K Saggi, M At T Oo, M Bl Om St R � Om, M Bl Om St R � Om, M Haddad, M I K Am Ien, M Sc, O D Har T, P J Buc K L Ey, P.-J Nor B� Ac K, R, R Ander Sson, R E C Aves, R E C Aves, R J, R R Son, S Das, S Djank Ov, S J G R Ossm An, S Ober M An, S P Das, S W Sal Ant, Thomas Müller   +38 more
core   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source