Results 91 to 100 of about 4,659,127 (281)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

An Alternative Metric for Detecting Anomalous Ship Behavior Using a Variation of the DBSCAN Clustering Algorithm [PDF]

, 2020
Carsten H. Botts
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Two new feature selection metrics for text classification

Automatika, 2019
Obtaining meaningful information from data has become the main problem. Hence data mining techniques have gained importance. Text classification is one of the most commonly studied areas of data mining.
Durmuş Özkan Şahin, Erdal Kılıç
doaj   +1 more source

Einstein's Equations and a Cosmology with Finite Matter

, 2015
We discuss various space-time metrics which are compatible with Einstein's equations and a previously suggested cosmology with a finite total mass. In this alternative cosmology the matter density was postulated to be a spatial delta function at the time
Clavelli, L., Goldstein, Gary R.
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Referee report. For: What gives a stroke publication impact? Assessing traditional and alternative metrics of scientific impact for papers published in the journal Stroke [version 1; peer review: 1 approved with reservations, 1 not approved]

, 2021
Robin Haunschild
openalex   +1 more source

Warped Electroweak Breaking Without Custodial Symmetry

, 2010
We propose an alternative to the introduction of an extra gauge (custodial) symmetry to suppress the contribution of KK modes to the T parameter in warped theories of electroweak breaking.
Agashe, Agashe, Archer, Atkins, Batell, Batell, Brummer, Cabrer, Carena, Davoudiasl, Davoudiasl, Delgado, Delgado, DeWolfe, Falkowski, Falkowski, Gero von Gersdorff, Gherghetta, Gherghetta, Goldberger, Goldberger, Gubser, Hassanain, Huber, Joan A. Cabrer, Karch, Klebanov, Luty, Mariano Quirós, Mert Aybat, Nakamura, Peskin, Randall, Round, von Gersdorff   +34 more
core   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source